Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

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      131 086
      (Development of a method for identification and source tracking of Ganoderma lucidum growing up in Fujian province by HPTLC) (Chinese)
      Y. ZHANG (Zhang Ying), K. JIANG (Jiang Kunxia), M. GUAN (Guan Mengyao), CH. WU (Wu Changhui), W. XU (Xu Wen)*, W. XU (Xu Wei), Y. LIN (Lin Yu), Q. CAI (Cai Qinqin) (*Cent. of Biomed. R&D, Fujian Univ. of Trad. Chinese Med., Fuzhou 350122, China,

      Chinese J. Pharm. Research 42 (2), 98-104 (2023). Ganoderma lucidum is the dry fruiting body of fungus, a medicinal plant, having the effect of relieving asthma and relieving nerves. Ganoderma lucidum is widely distributed in China and mainly concentrated in Zhejiang, Anhui, Shandong, Jilin, and Fujian. In this study, the HPTLC method for quality detection and origin traceability was established towards the medicinal material produced in Fujian and other areas. HPTLC of the ethanol extracts of the sample materials on silica gel with chloroform – acetonitrile – methanol – formic acid 130:15:2:2, three times to distances of 3 cm, 6 cm, 8 cm. Detection by spraying with 3 % sulfuric acid in ethyl acetate and heating at 105°C until the bands are clearly visualized, evaluation at UV 366 nm. The bands on the thin layer chromatogram were identified by fingerprint comparison using standard samples, and cluster analysis for the data of samples from different producing areas was performed using digital characterization. As results, the HPTLC analysis detected 17 distinct bands and among them, 11 components were identified, e.g. ganoderenic acid C (hRf 0.31), ganoderic acid C2 (hRf 33), ganoderic acid l (hRf 35), ganoderic acid G (hRf 41), ganoderic acid A (hRf 44), ganoderic acid B (hRf 46), ganolactone B (hRf 53), 3β,7β,15β-trihydroxy-11,15-dihydroxy-lanostane-8-alkene-24→20 lactone (hRf 56), ganoderenic acid D (hRf 61), ganoderic acid D (hRf 63) and 20 (21)-dehydrolucidenic acid A (hRf 65). A total of 10 HPTLC bands were identified in Fujian Ganoderma lucidum, among which ganoderic acid C2, ganoderic acid D and two unknown component bands (hRf 14 and 17) were unique and could be used as markers of Fujian Ganoderma lucidum. Thus samples of Fujian Ganoderma lucidum can be differentiated from those of other areas, when the Euclidean distance is 25 in Euclidean cluster analysis.

      Classification: 32e
      131 092
      Validated high-performance thin-layer chromatography-mass spectrometry method and stability study of linalool in the volatile oil of the rhizomes of Homalomena aromatica Schott
      A. K. GOSWAMI, N.L GOGOI, H. K. SHARMA* (*Dep. of Pharm. Sci., Faculty of Sci. & Eng., Dibrugarh Univ., Dibrugarh-786004, Assam, India,

      J Chromatogr Sci, 61 (3), 269-278 (2023). Development of a method for identification, quantification and stability study of linalool in Homalomena aromatica Schott, a herb with anti-rheumatism, nourishing and strengthening effects, and for the treatment of stomach disease. HPTLC hyphenated with MS for linalool on silica gel with toluene - ethyl acetate 19:1. Detection  with p-anisaldehyde reagent. The hRf of linalool is 35, identification of linalool at m/z 137, (M + H)+ by using MS technique. Study of the stability of linalool by investigating the effect of acid, base, UV, sunlight, thermal stress and H2O2 on it, the highest effect was observed with acidic pH with a 65 % degradation. The content of linalool was 58 % in the volatile oil of H. aromatica.

      Classification: 32e
      131 093
      Qualitative and quantitative analyses of four active components in different organs of Salvia deserta Schang by High-Performance Thin-Layer Chromatography
      L. WANG, W. WU, S. TIAN* (*Coll. of Trad. Chinese Med., Xinjiang Med. Univ., No. 393, Xinyi Road, Urumqi, Xinjiang 830017, China,

      J  Chromatogr Sci, 61(3), 225-233 (2023). Development of a method for analyzing rosmarinic acid (RA), caffeic acid (CA), ursolic acid (UA) and oleanolic acid (OA) in different organs of Salvia deserta Schang qualitatively and quantitatively by HPTLC (A) for RA and CA, on silica gel with chloroform – methanol - formic acid 20:4:1, quantitative absorption measurement at 330 nm; (B) for UA and OA, on silica gel F254 with cyclohexane - ethyl acetate - methanol 20:4:1, quantitative absorption measurement at 550 nm. The linearity ranges were 0.13-0.44, 0.01-0.09, 0.50-2.50 and 0.50-2.50 mg for RA, CA, UA and OA, respectively, with corresponding correlation coefficients of 0.9938, 0.9981, 0.9971 and 0.9969, respectively. The recovery rates were between 95 % and 105 %. LOD and LOQ were 50, 58, 25, 33 and 160, 191, 80, 106 ng for RA, CA, UA and OA, respectively.

      Classification: 32e
      131 094
      Development of a thin-layer chromatography - enzymatic test combination method for the isolation of α-glucosidase inhibitors from Thymelaea hirsuta
      S. ABID, A. MACIUK, R. FISHMEISTER, V. LEBLAIS, A. LEGSSYER, H. MEKHFI, A. ZIYYAT, M. AZIZ, A. LEKCHIRI, M. BNOUHAM* (*Lab. of Bio-resources, Biotechnol., Ethnopharm. & health, Dep. of Biol.. Fac. of Sci., Univ. Mohamed Ist, Boulevard Mohamed IV, BP: 717, Oujda 60 000, Morocco,

      J Chromatogr Sci, 61 (1), 66-73 (2023). Development of a rapid, easy and simple method for the isolation and purification of α-glucosidase inhibitors of the ethyl acetate extract of Thymelaea hirsuta (EaTh) by TLC-enzymatic test (TLC/EZ), after EaTh demonstrated previously a potent α-glucosidase inhibitory effect. Soxhlet extraction from Thymelaea hirsuta (T. hirsuta), separation on a silica gel column, TLC on silica gel. Detection of α-glucosidase inhibitors directly on the TLC plate using the glucose oxidase peroxidase method (GOD-POD), then characterization of active compounds using HPLC-MS analysis, resulting the main α-glucosidase inhibitors present in EaTh with a molecular ion [M + H]+ at m/z = 543. The proposed method is suitable for a reliable isolation and purification of α-glucosidase inhibitors present in EaTh and can be proposed as an interesting alternative to the classical method for the isolation and purification of α-glucosidase inhibitors in plant extracts.

      Classification: 32e
      131 089
      Validated smart different chromatographic methods for selective quantification of acefylline piperazine, phenobarbital sodium and methylparaben additive in bulk and pharmaceutical dosage form
      S. BOLTIA, S.E. ALGMAAL*, N.M. MOSTAFA, Y. S. EL SAHARTY (*Anal. Chem. Dep., Fac. of Pharm., Cairo Univ., Kasr El-Ainy St., ET-11562 Cairo, Egypt,

      J. Chromatogr. Sci., 61 (1), 56-65 (2023). Proposal of a method for the simultaneous determination of acefylline piperazine (ACEF) and phenobarbital (PHENO) in presence of methylparaben as additive in pharmaceutical dosage form by TLC on silica gel with chloroform – methanol - glacial acetic acid 20:80:1. Densitometric absorption measurement at 254 nm in the concentration range of 0.5 - 25 μg/band. Also, reversed phase liquid chromatography (RPLC) with diode array detection. Validation of both methods according to the International Conference on Harmonization guidelines and statistical comparison with a reported HPLC method. Successful application of the proposed planar chromatographic method firstly for the determination of ACEF and PHENO in pharmaceutical dosage form.

      Classification: 32a
      131 088
      (Study of the method for the quality control of Ganqingqinglan (Dracocephalum tanguticum Maxim.), a traditional Tibetan medicinal plant, by thin-layer chromatography) (Chinese)
      Y. FAN (FAN YINGYING)*, Q. MA (MA QINGQING), F. YANG (YANG FENGMEI), W. ZHANG (ZHANG WEI), G. LUO (LUO GUIFA) (*National Med. Prod. Admin. Key Lab. for Qual. Contr. of Trad. Chinese Med. & Tibet. Med., Qianghai Prov. Key Lab. for Modern. of Trad. Chinese Med. & Tibet. Med., Qinghai Prov. Drug Insp. & Test. Inst., Xining 810016, China,

      J. Chinese Trad. Patent Med. 44 (6), 1770-1772 (2022). Ganqingqinglan (Dracocephalum tanguticum Maxim.) is a traditional Tibetan medicinal plant, containing flavonoids, terpenes, polysaccharides. It has antihypoxic, antibacterial, antiviral, and hypoglycemic effects and is used as the main component in the traditional Tibetan medicine for the treatment of hepatitis and gastritis. For quality control, TLC of the plant extracts on silica gel (1) for oleanic acid, with toluene - ethyl acetate - glacial acetic acid 28:8:1, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 °C until the zones are clearly visualized, evaluation under UV 366 nm; (2) for chlorogenic acid, with toluene - methyl acetate - propanone - methanol - methyl acid 30:5:5:20:1, evaluation under UV 366 nm. The method was applied for the analysis of 18 batches of real life samples and proved to be simple, specific, reproducible, robust and well suitable for the purpose.

      Classification: 32e
      131 087
      Screening design and response surface methodology for the simultaneous estimation of carvedilol and ivabradine HCl by HPTLC method
      P. PRAJAPATI*, K. NAIK, P. TAILOR, S. SHAH (*Dep. of Qual. Assur., Maliba Pharm. Coll., Maliba Campus, Bardoli-Mahuva road, Tarsadi, Surat, Gujarat 394 350, India,

      J. Chrom Sci., 60 (9), 859-870 (2022). Development of an HPTLC method for the simultaneous estimation of carvedilol (CAR) and ivabradine (IVA). The combination of CAR and IVA is used for reduction of the heart rate and for achieving better exercise capacity in patients with chronic heart failure. The design approach based on the principles of analytical failure modes critical effect analysis (AFMCEA) and design of experiments (DoE) as per the upcoming ICH Q14 guideline were applied. Starting the AFMCEA by the identification of potential analytical failure modes followed by their critical effect analysis by a DoE-based screening design. Optimization of the high-risk failure modes by DoE-based response surface methodology. Framing the method operable design ranges and control strategy for optimized chromatography conditions. Validation of the HPTLC method as per ICH Q2 (R1) guideline. Application for the assay of facility design criteria (FDC) of CAR and IVA, giving the results in compliance with the labeled claim, and proven the developed method able to be used as an alternative to the published RP-HPLC method for quality control of FDC of CAR and IVA in the pharmaceutical industry.

      Classification: 32c
      131 085
      Green analytical chemistry-driven response surface modeling to stability-indicating chromatographic method for cilnidipine and application of HPTLC–MS for characterization of degradation products
      P. PRAJAPATI*, V. DIXIT, V. PULUSU, R. CHAUHAN, S. SHAH (*Department of Quality Assurance, Maliba Pharmacy College, Maliba Campus, Bardoli-Mahuva Road, Tarsadi, Mahuva, Surat 394 350, Gujarat,

      J. Sep. Sci. 2300332 (2023). HPTLC of cilnidipine on silica gel with n-heptane - ethyl acetate - triethyl amine 6:14:1. Quantitative determination by absorbance measurement at 254 nm. The hRF value for cilnidipine was 42. Linearity was in the range of 100-500 ng/zone. Intermediate precisions were below 2 % (n=3). LOD and LOQ were 24 and 72 ng/zone, respectively. Recovery was between 98 and 102 %.

      Classification: 32a