Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
  • Keyword register: select an initial character and browse associated keywords
  • Search by CBS edition: Select a CBS edition and find all related publications

Registered users can create a tailor made PDF of selected articles throughout CCBS search – simply use the cart icon on the right hand of each abstract to create your individual selection of abstracts. You can export your saved items to PDF by clicking the download icon.

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      119 105
      High-performance thin-layer chromatography method for the simultaneous determination of itopride, pantoprazole, and mosapride in their formulations and spiked human plasma
      R. SARAYA*, R. SALAM, G. HADAD (*Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt, dr_saraya@yahoo.com)

      J. Planar Chromatogr. 30, 299-306 (2017). HPTLC of itopride (1), pantoprazole (2), and mosapride (3) in human plasma on silica gel with methylene chloride ‒ ethyl acetate ‒ methanol ‒ 25 % ammonia 60:10:4:1. Quantitative determination by absorbance measurement at 289 nm. The hRF values for (1), (2) and (3) were 22, 41 and 62, respectively. Linearity was between 100 and 1500 ng/zone for (1) and (3), and between 70 and 1500 ng/zone for (2). The intermediate precision (n=3) was <2 % for (1) to (3). LOD and LOQ were 33 and 98 ng/mL for (1), 17 and 51 ng/mL for (2) and 30 and 91 ng/mL for (3). Average recovery rate was 99.2 % for (1), 99.1 % for (2) and 99.6 % for (3).

      Classification: 32f
      120 034
      Thin-layer chromatography of selected Achillea species on silica and CN silica stationary phases with fingerprint and chemometrics
      Anna HAWRYL*, M. HAWRYL*, R. SWIEBODA, M. WAKSMUNDZKA-HAJNOS (*Department of Inorganic Chemistry, Medical University of Lublin, Chod?ki 4A St, 20-093 Lublin, Poland, anna.hawryl@umlub.pl)

      J. Planar Chromatogr. 30, 392-400 (2017). HPTLC of 13 Achillea species on silica gel with toluene – ethyl acetate – formic acid 50:49:1. Detection by spraying with anisaldehyde reagent, followed by heating at 126 °C for 10 min. TLC chromatograms were photographed and processed with ImageJ program. Also TLC on cyano phase with 2-propanol – n-heptane 1:1 and ethanol – water 3:2 for dichloromethane extracts and methanol – water 2:3 for methanolic extracts. Detection by spraying with 1 % solution of diphenylborinic acid 2-aminoethylester in methanol, followed by drying and spraying with 5 % solution of polyethylene glycol in methanol. Detection under UV 366 nm. Principal component analysis, similarity and distance measures were used to confirm the similarity between the studied samples.

      Classification: 7, 32e
      120 070
      The influence of metallic impurities on the free silanol activity of commercial thin-layer chromatography adsorbents demonstrated by retention changes of basic/amphoteric compounds such as peptides
      R. GWARDA*, W. SZWERC, M. KOZAK, A. TUREK, A. TORBICZ, A. CHOMICKI, R. KOCJAN, D. MATOSIUK, T. DZIDO (*Department of Physical Chemistry, Chair of Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 4a Chod?ki St., 20-093 Lublin, Poland, radoslaw.gwarda@umlub.pl)

      J. Planar Chromatogr. 30, 375-385 (2017). HPTLC of synthetic peptides on silica gel and RP-18 with water and methanol with the addition of proper ion-pairing reagent to study the influence of metallic impurities on the retention and efficiency of separation of peptides. Detection by dipping into 2 % ninhydrin solution in acetone ‒ methanol ‒ glacial acetic acid 25:25:2. The contents of trace elements in areas scraped off from the chromatographic plates were determined by flame technique of atomic absorption spectrometry. The impurities present in the adsorbents may cause characteristic disruption of solute zone shape and overall distortion of the chromatogram during the development.

      Classification: 18b, 33a
      121 010
      Critical review on establishment and availability of impurity and degradation product reference standards, challenges faced by the users, recent developments, and trends
      D. SINGH, A. SAHU, S. KUMAR, S. SINGH* (*Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160 062, Punjab, India, ssingh@niper.ac.in)

      Trends Anal. Chem. 101, 85-107 (2018). Review of the different nomenclature, impurity testing policies, and the manner in which impurity tests and lists are provided in the monographs for the drug substances and_x000D_ drug products. The review included typical examples of multiple tests in pharmacopoeial monographs for impurities, including TLC methods. A list of private vendors supplying reference standards of impurities and degradation products for TLC was also included.

      Classification: 1
      121 041
      Qualitative and quantitative analysis of hydroxysafflor yellow A in safflower by using high-performance thin-layer chromatography
      T. HE (He Ting), Y. ZENG (Zeng Ya), X. ZHOU (Zhou Xiaoying)* (*Xinjiang Medical University, Urumqi 830011, Xinjiang, China, zhouxiaoying@xjmu.edu.cn)

      J. Planar Chromatogr. 31, 129-134 (2018). HPTLC of hydroxysafflor yellow A in safflower on silica gel with 3.6 % hydrochloric acid – methanol – ethyl acetate 7:3:1. Quantitative determination by absorbance measurement at 399 nm. The hRf value for hydroxysafflor yellow A was 60. Linearity (starting from LOD) was in the range of 62-793 ng/zone with r=0.9991. The intermediate precision was below 3 % (n=6). The LOD and LOQ were 59 and 169 ng/zone, respectively. Recovery was between 96 and 102 %.

      Classification: 8a
      121 079
      Determination of lormetazepam in tablets using high-performance thin-layer chromatography, high-performance liquid chromatography, and derivative spectrophotometry methods
      M. GACKOWSKI*, M. KOBA, K. MADRA-GACKOWSKA, R. PLUSKOTA, E. SIEDLECKA, Z. SIEDLECKI, M. MARSZALL (*Department of Toxicology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz of Nicolaus Copernicus University in Toru?, 85-094 Bydgoszcz, Poland, gackowskimarcin@wp.pl)

      J. Planar Chromatogr. 31, 235-242 (2018). HPTLC of lormetazepam on silica gel with acetonitrile – water 3:2. Quantitative determination by absorbance measurement at 241 nm. The hRf value for lormetazepam was 44. Linearity was in the range of 1.0-7.5 μg/zone. The intermediate precision was below 4 % (n=3). The LOD and LOQ were 0.26 and 0.77 μg, respectively. Average recovery was 100.9 %. Comparable results were obtained with a validated HPLC method.

      Classification: 32a
      122 023
      eicCluster software, an open-source in silico tool, and on-surface syntheses, an in situ concept, both exploited for signal highlighting in high-resolution mass spectrometry to ease structure elucidation in planar chromatography
      D. FICHOU, I. YÜCE, Gertrud MORLOCK* (*Justus Liebig Univ. of Giessen, Inst. of Nutrit. Sci., Chair of Food Sci., & Interdiscipl. Res. Center, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany, Gertrud.Morlock@uni-giessen.de)

      J. Chromatogr. A 1577, 101-108 (2018). In order to overcome the difficulty of the interpretation of the MS signals present at a low intensity for unknown degradation products or impurities, a new strategy and open-source software called eicCluster was developed. It offered unsupervised machine learning algorithms and powerful interactive visualization tools that made data processing fast and intuitive. The low-intensity HPTLC-HRMS signals were highlighted in a stressed formulation by using eicCluster. Thus, even compound ions present at low intensities were separated in subclusters from background signals (in silico highlighting). The respective preprocessing led to intensity-agnostic signals and the t-SNE algorithm clustered mass signals based on their similarity. The resulting 2D maps allowed a new view on the data set to such low-intensity target molecules in complex mixtures. Moreover, the targeted on-surface synthesis of degradation products (in situ highlighting) was shown to support a fast structure elucidation, when standards are not commercially available. It allowed a better understanding of the proposed degradation reactions in the formulation. Comparison with the results of stressed samples as well as the proposed degradation products of on-surface synthesis proved that in silico and in situ signal highlighting substantially eased structure elucidation and data processing.

      Classification: 3e, 4e, 32c
      122 046
      Rapid discrimination of different Apiaceae species based on HPTLC fingerprints and targeted flavonoids determination using multivariate image analysis
      E. SHAWKY*, R. ABOU EL KHEIR (*Department of Pharmacognosy, Faculty of
      Pharmacy, Alexandria University, Alexandria 21521, Egypt, shawkyeman@yahoo.com)

      Phytochem. Anal. 29, 452-462 (2018). HPTLC of apigenin(1), luteolin (2), kaempferol (3), quercetin (4), kaempferol‐3‐O‐glucoside (5), quercetin‐3‐O‐glucoside (6), isorhamnetin‐3‐O‐neohesperidoside (7) and rutin (8) in the fruits and aerial parts of Foeniculum vulgare (fennel), Pimpinella anisum (anise), Carum carvi (caraway), Cuminum cyminum (cumin), Coriandrum sativum (coriander), Apium graveolens (celery), Petroselinum crispum (parsley), and Anethum graveolens (dill) on silica gel with ethyl acetate – methanol – water – acetic acid 3:1:1:1. Quantitative determination by absorbance measurement at 254 nm. Heat maps and hierarchical clustering were performed for image processing. The hRF values for (1) to (8) were 97, 90, 83, 73, 30, 17, 7 and 2, respectively. LOD and LOQ were 54 and 166 ng/zone for (1), 52 and 157 ng/zone for (2), 58 and 177 ng/zone for (3), 37 and 112 ng/zone for (4), 57 and 172 ng/zone for (5), 54 and 164 ng/zone for (6), 55 and 169 ng/zone for (7) and 58 and 178 ng/zone for (8), respectively. The intermediate precision was <2 % (n=6). Average recovery was 98.4 % for (1), 92.3 % for (2), 95.3 % for (3), 96.8 % for (4), 94.5 % for (5), 95.6 % for (6), 95.1 % for (7) and 97.3 % for (8).

      Classification: 8a, 8b
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