Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      111 057
      Cleaning validation using HPTLC
      Birgit BOECKEL (Bayer Weimar GmbH & Co. KG, Product Supply Pharma, QC Raw Materials, Doebereiner Str. 20, 99427 Weimar, Germany, birgit.boeckel@bayer.com)

      CBS 107, 2-4 (2011). HPTLC of chloroform extracts from cleaning swabs on silica gel with toluene - ethyl acetate 3:2 after 10 min chamber saturation. Densitometric evaluation for identification of substances by spectra recording at 200-350 nm, quantification with 3-level calibration. Detection by immersion in methanol - sufuric acid 9:1 and heating at 105 °C for 5 min. Cleaning validation by HPTLC (i.e. determination of residues of hormonal ingredients) can be achieved with the required accuracy. The method is simple and quick and the quantitative results are precise.

      Classification: 32a
      111 074
      (Study of the quality standard for Dieda Zhitong microemulsion spray) (Chinese)
      L. GUO (Guo Lirong), H. LIU (Liu Hongwei), L. ZHOU (Zhou Liling)* (*Guangzhou Univ. of Traditional Chinese Med., Guangzhou 510006, China)

      Chinese J. of Lishizhen Trad. Med. & Pharm. 22 (5), 1045-1048 (2011). Dieda Zhitong microemulsion spray is a traditional Chinese medicine effective in invigorate the circulation of blood, relieving blood stagnate, subsidence of a swelling, stop bleeding and relieving pain caused by injuries from falls, fractures, contusions, strains and traumatic injuries. For quality control, TLC of the extracts of the medicine 1) for Cnidium monnieri L. Cuss and Doubleteeth Pubescent Angelica root, on silica gel with petroleum ether (30-60 ºC) – ethyl acetate 9:1, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 °C until the zones were visible, viewing under UV 366 nm; 2) for Ligusticum wallichii and Rheum officinale on silica gel with petroleum ether (30-60 ºC) – ethyl acetate 9:1, detection under UV 254 nm; 3) for Oleum Ocimi gratissimi on silica gel with cyclohexane – ethyl acetate 4:1, detection by spraying with 10 % ferric chloride in ethanol and heating at 105 °C until the zones were visible; 4) for Oleum Anisi stellati on silica gel with petroleum ether (60-90 ºC) – ethyl acetate 19:1, detection by spraying with 5 % vanillin in ethanol and heating at 105 °C until the zones were visible; 5) for Oleum Eucalypti on silica gel with cyclohexane – diethyl ether - ethyl acetate 16:3:1, detection by spraying with 5 % vanillin in ethanol and heating at 105 °C until the zones were visible.

      Classification: 32e
      111 092
      (Study of the quality control of Chongderi pills) (Chinese) Chinese J
      P. KOU (Kou Peiyan) (Baotou Municip. Test Center for Foods & Pharm., The Inner Mongolia Autonomous Region, Baotou 014030, China)

      of Northern Pharmacy 9 (4), 4-5 (2012) Chongderi pills are a herbal traditional Mongolian medicine for treating diarrhea, invigorating the circulation of blood, stimulating the menstrual flow, and dissipating blood stasis, etc. For quality control, TLC on silica gel 1) for Radix aucklandiae, with benzene – methanol 27:1, detection by spraying with 1% vanillin in sulfuric acid – ethanol, detection under daylight; 2) for Rhizoma acori tatarinowii, with petroleum ether (60-90 º) – ethyl acetate 9:1, detection by exposure to iodine vapors, viewing under daylight; 3) for safflower carthamus, with ethyl acetate – formic acid – water – methanol 35:10:15:2, detection under daylight. Identification by comparison with the standards.

      Classification: 32e
      111 112
      (Study on the method for the differentiation of Ganoderma lucidum from its counterfeit, Ganoderma) (Chinese)
      J. PENG (Peng Jiangli), L. WANG (Wang Lijing), T. LIU (Liu Tasi), W. DONG (Dong Weiwei), SH. LI (Li Shunxu), D. YANG (Yang Dajian)* (*The Key Lab. of Research on Pharmacy & Molecular Pharmacology of Trad. Chinese Med. at Shenzhen, Guangdong, Shenzhen 518057, China)

      Chinese J. of Lishizhen Trad. Med. & Pharm. 22 (7), 1703-1704 (2011). Ganoderma lucidum as a traditional Chinese medicinal herbal crude drug is the dried fruiting body of Ganoderma. It is used for mind and body tranquilization and to relieve cough and asthma, and is prescribed clinically to treat palpitation, lung deficiencies, and shortness of breath. TLC of the extracts of the crude drugs on silica gel with dichloromethane – ethanol – formic acid 16:10:1, detection under UV 254 nm. Identification of Ganoderma lucidum based on the characteristic marker compound ganodermic acid A which is not found in the counterfeits. Differentiation also by identifying the shape and properties by microscopy.

      Classification: 32e
      111 133
      A simple TLC–densitometric method for the estimation of labetalol hydrochloride in tablets
      S. WANKHEDE*, A. MAHAJAN, S. CHITLANDE (*Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, Maharashtra, India, drsagarwankhede@rediffmail.com)

      J. Planar Chromatogr. 25, 145-149 (2012). HPTLC of labetalol hydrochloride on silica gel with ethyl acetate - methanol 4:1 + 1 drop ammonia. Quantitative determination by absorbance measurement at 309 nm. The hRf of labetalol was 69. Linearity was in the range of 400-2400 ng/band. The intermediate/interday/intra-day precision was below 2 %. Recovery was in the range of 98.6-100.5 %.

      Classification: 32a
      111 149
      (Study of the method for the quality control of Fangji Fuling Tang decocted extract) (Chinese)
      W. ZHANG (Zhang Wenwei), L. YAN (Yan Lili), ZH. CHEN (Chen Zhongxin)* (*Heilongjiang Univ. of Trad. Chinese Med., Heilongjiang, Harbin 150040, China)

      J. of Inform. on Trad. Chinese Med. 29 (6), 96-98 (2012). Fangji Fuling Tang decocted extract is a herbal TCM preparation for the treatment of chronic nephritis edema, cardiac edema, etc. For quality control the method of the Chinese Pharmacopeia is improved. TLC on silica gel 1) for Radix Stephaniae Tetrandrae and the standards (+)-tetrandrine, hanfangichin B, and fangchinoline, with chloroform – methanol – acetone 6:1:1, detection by spraying with 5 % potassium iodobismuthate in hydrochloric acid – water 1:200 and viewing in daylight; 2) for Radix Astragali seu Hedysari and the standard astragaloside A, with the lower phase of chloroform – methanol – water 13:7:2, detection by spraying with 10 % sulfuric acid in ethanol and heating mildly, viewing in daylight; 3) for Radix Glycyrrhizae, with the lower phase of ethyl acetate – formic acid – glacial acetic acid - water 15:1:1:1, detection under UV 366 nm. Quantification of (+)-tetrandrine, hanfangichin B, and fangchinoline by HPLC.

      Classification: 32e
      112 018
      Chromatographic methods for the simultaneous determination of metoprolol tartrate and hydrochlorothiazide in the presence of hydrochlorothiazide degradation product
      N. RAMADAN*, H. MOHAMED, A. MOSTAFA (*Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El-Aini, 11562 Cairo, Egypt, analpharm@yahoo.com)

      J. Planar Chromatogr. 26, 510-516 (2013). HPTLC of metoprolol tartrate (1) and hydrochlorothiazide (2) and hydrochlorothiazide degradation product (3) on silica gel with acetate - toluene - methanol - ammonium hydroxide 33 % 10:6:3:1. Quantification by absorbance measurement at 275 nm. The hRf values for compounds (1) to (3) were 8, 20 and 38, respectively. Linearity was in the range of 5-40 µg/zone for (1) and 3-10 µg/zone for (2). LOD and LOQ were 730 and 2180 ng/zone for (1) and 80 and 250 ng/zone for (2). Recovery was in the range of 98.4-101.9 % for both (1) and (2). Intermediate/interday/intra-day precision was below 1 %. The method showed comparable results with a validated HPLC method.

      Classification: 6
      112 055
      Staining of some synthetic oligopeptides using ninhydrin solution
      R. GWARDA*, A. TOMCZYSZYN, A. MISICKA, T. DZIDO (*Department of Physical Chemistry, Chair of Chemistry, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, Poland, radoslaw.gwarda@umlub.pl)

      J. Planar Chromatogr. 26, 455-456 (2013). HPTLC of oligopeptides on RP-18 (chromatography described in R. Gwarda, A. Tomczyszyn, A. Misicka, T.H. Dzido, Acta Chromatogr., in print, 2015). Detection by spraying or dipping for 2 s with 2 % ninhydrin solution in 1) acetone - glacial acetic acid 25:1 or 2) acetone - methanol - glacial acetic acid 25:25:2, followed by heating at 80 ºC. Results showed that short dipping of the plate in ninhydrin solution resulted in a better detectability of peptides than spraying it with the same solution. Solution 2) with methanol made the ninhydrin reaction faster, and colored all zones in a distinct pink/red color, unfortunately one peptide (no. 1) showed poor color intensity.

      Classification: 19
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