Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      110 127
      Simultaneous determination of propanolol hydrochloride and flunarizine dihydrochloride in bulk and capsule using reversed-phase high-performance thin layer chromatography/densitometry
      A. PATIL, A. SHIRKHEDKAR*, S. SURANA, P. NAWALE (*R.C. Patel Institute Pharmaceutical Education and Research, Shirpur Dist., Dhule, India, atulshirkhedkar@rediffmail.com)

      J. Chil. Chem. Soc. 57, 1033-1035 (2012). HPTLC of propanolol hydrochloride (1) and flunarizine dihydrochloride (2) in combined dosage form on silica gel with methanol - toluene - ammonia 14:6:1. Quantitative determination by absorbance measurement at 267 nm. The hRf of compounds (1) and (2) were 63 and 48, respectively. Linearity was in the range of 800-4800 ng/zone for (1) and 200-1200 ng/zone for (2). Limits of detection and quantification were 25 and 75 ng/zone for (1) and 16 and 48 ng/zone for (2), respectively. Intermediate/intra-day/inter-day precision was below 2.0 % (n=6). Recovery for both (1) and (2) was between 99.3 and 100.9 %.

      Classification: 32a
      110 150
      Stability-indicating HPTLC method for the determination of atorvastatin and ezetimibe - application to pharmaceutical dosage forms
      S. WALODE*, A. KASTURE, S. WADODKAR (*Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (Bk), Lonavala, Pune 410401, Maharashtra, India, sanjuwalode@rediffmail.com)

      J. Planar Chromatogr. 25, 81-84 (2012). HPTLC of atorvastatin (1) and ezetimibe (2) on silica gel with methanol - toluene - chloroform - triethylamine 2:16:1:1. Quantitative determination by absorbance measurement at 259 nm. The hRf values of compounds (1) and (2) were 7 and 37, respectively. Linearity was in the range of 500-1500 ng/band for both (1) and (2). Intermediate/inter-day/intra-day precision was below 2 % (n=3). Mean recovery was 99.7 % for both active agents.

      Classification: 32a
      110 168
      (An improved method for the quality control of Langchuang pills) (Chinese)
      X. YANG (Yang Xiaoying) (Linying County People’s Hosp. No.2, Henan, Linying 462600, China)

      Chinese J. of Clin. Res. on Trad. Chinese Med. 4 (9), 34-35 (2012). Langchuang pills are a herbal TCM preparation for clearing heat, removing toxicity and invigorating the circulation of blood. For quality control, TLC of the extracts of the preparations on silica gel 1) for the root of red-rooted salvia, with chloroform – benzene 5:1, detection by viewing in daylight; 2) for Radices Rehmanniae, with chloroform – methanol 8:1, detection by spraying with a saturated solution of 2,4-dinitrophenylhydrazine in ethanol and viewing in daylight; 3) for the rhizome of Chinese Goldthread, with benzene – chloroform – ammonia 5:3:1, detection at UV 366 nm.

      Classification: 32e
      111 006
      Polarity-adjustable reversed phase ultrathin-layer chromatography
      J.Z. HALL, M.T. TASCHUK, M.J. BRETT* (*Dep. Electr. & Comp. Engin., Univ. of Alberta, 2nd Floor ECERF, Edmonton, Alberta T6G 2V4, Canada)

      J. Chromatogr. A 1266, 168-174 (2012). RP-TLC plates modified with C18, C8 or C2 are available on the market, however, RP-plates with tunable polarity have not been reported. Because of the limited variety of RP-plates mobile phase optimization is needed which is often time consuming. The presented polarity-adjustable RP-UTLC plates simplify the mobile phase screening process and expand the selection of reversed phase plates. The plates were prepared using the glancing angle deposition (GLAD) technique to deposit SiO2 nanopillars on glass plates and functionalized with octadecyltrichlorosilane for hydrophobicity. By O2 plasma treatment the silane carbon chain was shortened and COOH groups were introduced to the surface, producing plates with finely tunable polarities. Confirmation of the tuning of surface polarities by measurement of retention behavior changes in the separation of a model dye mixture of Sudan blue and Sudan IV, the elution order of which reversed as a result of the change in surface polarity. Testing on commercial RP-plates showed no change in the separation behavior which proves that plasma treatment of GLAD structures with highly accessible surfaces improves control over interfacial properties, producing better reverse phase separations. UTLC of Sudan blue and Sudan IV in toluene on the new RP-UTLC plates in horizontal developing chamber with acetonitrile, detection in visual light by recording of the development process by video camera).

      Classification: 3b, 30
      111 040
      Thin-layer chromatography with stationary phase gradient as a method for separation of water-soluble vitamins
      CLAUDIA CIMPOIU*, ANAMARIA HOSU, ANITTA PUSCAS (*“Babes-Bolyai” Univ., Faculty of Chem. & Chem. Eng., 11 Arany Janos, 400082 Cluj-Napoca, Romania)

      J. Chromatogr. A 1223, 142-146 (2012). Hydrophilic vitamins play an important role in human health, and their lack or excess produces specific diseases. Development of a method for the analysis of these compounds for monitoring their content in pharmaceuticals and food. Application of TLC in the simultaneous analysis of hydrophilic vitamins with the optimized conditions towards different chemical characteristics of analytes. Due to the difficulty of separation of the structural analogues of these hydrophilic vitamins in one chromatographic run, taking the advantage of TLC to perform 2-D separations by using stationary phase gradient of silica gel and cellulose, achieving the highest resolution by combining two systems with different selectivity. For the gradient TLC the silica gel and cellulose plates were cut in narrow strips each of 1.5 x 9 cm and connected face-to-face. Development with methanol - benzene - formic acid 6:4:1. Detection under UV 254 nm. The method has been used for identifying the water-soluble vitamins in alcoholic extracts of Hippophae rhamnoides and of Ribes nigrum.

      Classification: 27
      111 065
      (Study on the method for the quality control of Qufengjiangu tablets) (Chinese)
      X. CHEN (Chen Xueting)*, S. LI (Li Sumei), Y. LI (Li Yangxue) (*Guangzhou Univ. of Trad. Chinese Med., Guangdong, Guangzhou, 510405, China)

      Chinese J. of Today’s Pharm. 22 (11), 690-692 (2012). Qufengjiangu tablets are a herbal TCM for the treatment of waist and knee pain and rheumatic arthralgia. For quality control, TLC on silica gel 1) for Radix Angelicae Pubescentis, with cyclohexane – ethyl acetate – formic acid – glacial acetic acid 70:20:2:3, detection under UV 366 nm; 2) for Radix Notoginseng and Radix Dipsaci, with n-butanol – ethyl acetate – 10 % diluted ammonia 4:1:5, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 °C, viewing in daylight; 3) Herba Taxilli, with toluene saturated with water – ethyl formate – formic acid 5:4:1, detection by spraying with 5 % aluminium chloride in ethanol and heating at 105 °C, viewing under UV 366 nm. Quantification of osthole by HPLC.

      Classification: 32e
      111 082
      HPTLC method for analysis of sertraline in pure bulk and lipidic nano delivery system
      A. HUSSAIN, M. RAHMAN*, M. HUSSAIN, M. MIRZA, Z. IQBAL, R. HARWANSH, L. RATNAKAR (*Faculty of Pharmacy, Integral University, Kursi Road, Lucknow-226026, India, rahmanpharma@gmail.com)

      J. Liq. Chromatogr. Relat. Technol. 36, 700-716 (2013). HPTLC of sertraline in bulk and formulation on silica gel with toulene - ethyl acetate 1:5+1 drop ammonia. Quantitative determination by absorbance measurement at 273 nm. The hRf value of sertraline was 70. Linearity was in the range of 25-2000 ng/zone. LOD and LOQ were 15.3 and 46.8 ng/zone. Intermediate precision was below 0.83 %. Recovery range was in the range of 99.6-100.3 %. The hRf values of acid and base-induced degradation products were 40, 52, 90 and 25.

      Classification: 32a
      111 100
      (Study of the method for the quality control of Jiegu Xujin capsules by thin-layer chromatography) (Chinese)
      F. LIAO (Liao Fang)*, D. ZHANG (Zhang Dan), M. LI (Li Min), CH. LI (Li Chunlin), M. LAN (Lan Minghui), R. YIN (Yin Rongli) (*Chengdu Municip. Xindu District Hosp. of Trad Chinese Med., Sichuan, Chengdu 610500, China)

      Jiangxi J. of Trad. Chinese Med. 43 (354), 62-64 (2012). Jiegu Xujin capsules are a herbal TCM for the treatment of fractures, bone dislocation and joint pain. For quality control, TLC on silica gel 1) for Rhizoma Drynariae and the standard naringin, with cyclohexane – ethyl acetate – formic acid – water 2:24:5:6, detection under UV 366 nm; 2) for Radix Angelicae Sinensis and Rhizoma Ligustici Chuanxiong, with n-hexane – ethyl acetate 9:1, detection under UV 366 nm; 3) for Eupolyphaga seu steleophaga, with toluene – dichloromethane – acetone 10:10:1, detection by spraying with 3 % vanillin in sulfuric acid – ethanol 1:200 and heat at 105 °C, viewing in daylight; 4) for Radix Notoginseng and the standards ginsenoside Rb1, Re, Rg1, R1, with the lower phase of chloroform – methanol – water 13:7:2, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 °C, viewing under UV 366 nm.

      Classification: 32e
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