Proc. Intern. Symp. on Planar Separations Plan. Chrom. 111-121 (2003). TLC of 14C-labeled 6a-hydroxytaxol and 4-hydroxytolbutamide on silica gel with toluene - acetone - formic acid 60:39:1 in a horizontal chamber, separation of 6b-hydroxy-testosterone on silica gel with dichloromethane - acetone 4:1.After drying the plates were placed in contact with a phosphor imaging plate (IP) for 12 h. The amount of unchanged drug and metabolites were determined using a photo Film.

J. Pharmaceut. Biomed. Analysis 31, 1185-1189 (2003). TLC on silica gel with chloroform - acetone 9:1 in an unsaturated chamber. Quantitation by densitometry at 254 nm. Comparison of TLC method with reversed phase HPLC analysis.

J. Planar Chromatogr. 17, 132-136 (2004). TLC and HPTLC of pravastatin, compactin and by-products (e. g. epi-pravastatin sodium salt and pravastatin-lactone) on silica gel in a twin-trough chamber with toluene - dichloromethane - tetrahydrofuran 23:1:1 for samples from ketone reduction and toluene - acetone - glacial acetic acid 20:30:4 for samples from compactin hydroxylation. Quantitative determination by reflectance measurement at 275 and 238 nm respectively.

J. Liq. Chrom. Rel. Technol. 27, 2047-2056 (2004). TLC of bromhexin on silica gel with n-butanol - glacial acetic acid - water 260:77:75 in a twin-trough chamber after at least 3 h of saturation. Quantitative determination at 325 nm by absorbance measurement. The method is selective, precise, and accurate and can be used for routine analysis of pharmaceutical preparations in pharmaceutical industry quality control laboratories.

IPC 56th 2004, Abstract No. GP-5. Simultaneous HPTLC determination of amlodipine and atenolol on silica gel with ethyl acetate - methanol - ammonia 60:40:3. Quantitative determination by scanning at 254 nm. The method was found linear in the range of 0.5 – 5.0 mg/mL amlodipine and 5.0 mg – 50 mg/mL atenolol. Recovery was 98.11 – 101.5 % for both of the compounds. The method was validated for accuracy, precision, linearity, specificity, LOD, and LOQ.

J. Planar Chromatogr. 17, 224-228 (2004). TLC of fluvoxamine and moclobemide on silica gel in horizontal chambers with benzene - acetone - ethanol - 25 % ammonia 9:7:2:1. Densitometric detection and quantification were performed at 249 nm and 236 nm, respectively. The range of linearity was 1 - 10 µg per spot; the RSD was less than 2.5 % for densitometry and less than 5.1 % for videodensitometry.

J. Pharm. Biomed. Anal. 39, 581-586 (2005). For post-production quality control of camptothecin derivatives irinotecan (CPT 11) and topotecan (TPT), HPLC and HPTLC methods have been developed which were suitable for identification, determination of purity and quantification. HPTLC on silica gel with methylene chloride - methanol - formic acid - water 82:24:2:1. After development, the plate was soaked in 15 % paraffin in n-heptane. Quantitative determination by fluorescence measurement at 366/>400 nm. The method was linear within the range of 100-1000 ng/mL for both CPT-11 and TPT. The method was validated for accuracy, precision, LOD, and LOQ.

Abstract GP-18, IPC (2005). HPTLC of nimesulide and chlorzoxazone in tablets on silica gel (prewashed with methanol) with toluene - acetone - ammonia 50:50:4. Paracetamol was used as internal standard. Quantitative determination by absorbance measurement at 265 nm. Nimesulide, chlorzoxazone and paracetamol showed hRf values of 80, 73 and 42, respectively. Linearity was obtained between 0.2-1.0 mg/mL with recovery rates of 99.6-100.3 % for both compounds.The method was validated for accuracy, precision, linearity, LOD, and LOQ.