Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
  • Keyword register: select an initial character and browse associated keywords
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      114 074
      (Study on the method for the quality control of Ganmaoling Jiaonang capsules) (Chinese)
      K. KUANG (Kuang Kaixing)*, M. CHENG (Cheng Min) (*Anhui Dongsheng Pharm. Logistics Co. Ltd., Jiangsu, Huaibei 235000, China)

      Heilongjiang Med. J. 26 (5), 746-750 (2013). Ganmaoling Jiaonang capsules are a TCM preparation composed of traditional Chinese herbal and Western drugs, with antipyretic and analgesic effects, which is used for headaches, fever, runny nose, sore throat, etc. For quality control, TLC on silica gel (1) for Evodia lepta (Spreng.) Merr with water-saturated toluene – ethyl acetate – formic acid 5:4:1, detection at UV 366 nm; (2) for Herba Bidentis bipinnate and Herba Bidentis pilosae with chloroform – methanol – formic acid 35:5:2, detection by (A) exposure to ammonia vapor and evaluation under white light and (B) spraying with 10 % sulfuric acid in ethanol and heating at 105 °C until the zones are visible; (3) for Ilex asprella (Hook. et Arn.) Champ. ex Benth. with benzene – acetone 9:1, detection at UV 366 nm. Quantitation of 4-acetamidophenol, chlorpheniramine maleate and caffeine by HPLC.

      Classification: 32e
      114 095
      (Studies on the method of the quality control of Yinyanghuo Tongluo Wan pills by TLC) (Chinese)
      SH. WU (Wu Shifu)*, H. WANG (Wang Hong) (*Shandong Qual. Insp. Center for Med. Instr. Prduct, Shandong, Jinan 250101, China)

      Chinese J. of Pharm. Research 33 (6), 328-331 (2014). Yinyanghuo Tongluo Wan pill is a TCM preparation for special treatment of diabetic peripheral neuropathy. For quality control, TLC on silica gel (1) for processed Epimedium and the standard icariin with ethyl acetate – butanone – formic acid 10:1:1:1, detection by spraying with 3 % aluminum trichloride in ethanol and heating mildly until the zones are visible at UV 366 nm; (2) for Panax ginseng C. A. Mey., ginsenoside Rb1, ginsenoside Re, and ginsenoside Rg1 with chloroform – methanol – water 13:7:2, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 °C until the zones are visible and at UV 366 nm; (3) for Ligusticum chuanxiong Hort. with cyclohexane - ethyl acetate 9:1, detection at UV 366 nm; (4) for Paeonia lactiflora Pall. and paeoniflorin with chloroform – methanol – ethyl acetate – concentrated ammonia 20:8:4:1, detection by spraying with 5 % vanillin in sulfuric acid – ethanol 1:4, followed by heating until the zones are visible; (5) for Atractylodes macrocephala Koidz. with petroleum ether (60-90 °C), detection by spraying with 5 % vanillin in sulfuric acid – ethanol 1:4, followed by heating until the zones are visible; (6) for Cassia twig with petroleum ether (60-90 °C) – ethyl acetate 17:3, detection by spraying with 5 % vanillin in sulfuric acid – ethanol 1:4, followed by heating at 105 °C until the zones are visible, and at UV 366 nm.

      Classification: 32e
      116 069
      High-performance thin-layer chromatography/desorption
      electrospray ionization mass spectrometry imaging of the crude extract from the peels of Citrus aurantium L
      B. BAGATELA, A. LOPES, E. CABRAL, F. PERAZZO, D. IFA* (*Department of Chemistry,
      Centre for Research in Mass Spectrometry, York University, Toronto, Ontario, M3J 1P3, Canada, ifadr@yorku.ca)

      (Rutaceae). Rapid Commun. Mass Spectrom. 29, 1530-1534 (2015). HPTLC of complex phytoconstituents in the peels of Citrus aurantium on silica gel with ethyl acetate - acetic acid - formic acid - water 100:5:5:13. Detection by spraying with vanillin reagent. Images were acquired by desorption electrospray ionization mass spectrometry in the positive ionization mode. The method allowed the identification of 20 compounds.

      Classification: 32e
      117 072
      Immunomodulatory N-acyl dopamine glycosides from the Icelandic marine sponge Myxilla incrustans collected at a hydrothermal vent site
      E. EINARSDOTTIR, H. LIU, J. FREYSDOTTIR, C. HELD GOTFREDSEN, S. OMARSDOTTIR* (*Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Reykjavik, Iceland; sesselo@hi.is)

      Planta Medica 82, 09/10, 903-909 (2016). To monitor the sorbent phase purification of a chloroform subfraction of the sponge Myxilla incrustans, TLC of fractions on silica gel with dichloromethane – methanol – formic acid 900:100:1, detection with Dragendorff’s reagent. The four positive fractions were purified by preparative HPLC, yielding three new N-acyl dopamine/dehydrotyrosine glycosides: myxillins A, B and C._x000D_

      Classification: 11, 17c, 18a, 32e
      118 024
      Thin layer chromatography coupled with electrospray ionization mass spectrometry for direct analysis of raw samples
      B. HU, G.-Z. XIN, P.-K. SO*,Z.-P. YAO* (*Dep. of Appl. Biol. & Chem. Technol., The Hong Kong Polytechnic Univ., Hung Hom, Kowloon, Hong Kong Spec. Administr. Region, China, bckin@polyu.edu.hk,zhongping.yao@polyu.edu.hk)

      J. of Chromatogr. A 1415, 155-160 (2015). Presentation of a technique for direct analysis of raw samples by TLC coupled with electrospray ionization mass spectrometry (ESI-MS) instead of conventional MS analysis, which for raw samples commonly requires time-consuming and laborious sample pretreatment and separation using HPLC or GC. The analytes of interest could be extracted, ionized and detected by ESI-MS with much reduced matrix interference because the interfering compounds were retained by the sorbent material of the TLC plate. Demonstration by applying in direct analysis of samples containing common interfering compounds, e.g. salts and detergents. Rapid detection and quantification of target analytes in raw samples showed that the TLC-ESI-MS method was simple, rapid, efficient and could be effectively applied in offline and online separation and detection of different components in raw samples, e.g. plant extracts.

      Classification: 4e, 32e
      119 026
      Five new triterpenoid saponins from the rhizomes of Panacis majoris and their antiplatelet aggregation activity
      M. LI (Li Min), F. LIU (Liu Fen), Y. JIN (Jin Yong-Ri), X. WANG (Wang Xiao-Zhong), Q. WU (Wu Qian), Y. LIU (Liu Ying), X. LI (Li Xu-Wen)* (*College of Chemistry, Jilin University, Changchun, China; xwli@jlu.edu.cn)

      Planta Medica 83(03/04), 351-357 (2017). Acid hydrolysis of five new dammarane-type saponosides extracted from Panax japonicus var. major rhizomes for 5 h in methanol – HCl 1:1 in sealed capillary at 80°C, then TLC on silica gel with n-butanol – acetic acid – water 5:1:4 (upper phase) and with chloroform – methanol – water 16:8:1. After derivatization with aniline phthalic acid reagent, sugar moieties were identified as glucose units by comparison to standards. Note that in the title, by ignorance of the Latin grammar, the authors wrote “Panacis majoris” instead of the nominative “Panax major”. In the names of the compounds, the –ane or –ene ending was often also omitted.

      Classification: 4e, 6, 9, 14, 32e
      119 097
      Stability-indicating HPTLC method for studying stress degradation behavior of sulbutiamine HCl
      N.F. FARID, N.S. ABDELWAHAB* (*Pharm. Anal. Chem. Dep., Faculty of Pharmacy, Benisuef Univ., Benisuef, Egypt, nadasayed2003@yahoo.com)

      J. Chromatogr. Sci. 54 (4), 609-617 (2016). HPTLC of sulbutiamine (SUL) in the presence of different degradation products after subjecting the drug to stress conditions (according to ICH: neutral, alkaline and acidic hydrolysis, oxidation, photodegradation and dry heat degradation), on silica gel aluminum foil with acetone – methylene chloride – ammonia buffer (pH 8.5±0.2) 14:6:1. Densitometric evaluation at 254 nm. The calibration curve was between 0.4–5.0 µg/zone with good correlation coefficients. The LOD and LOQ were 110 and 330 ng/zone, respectively. Structure elucidation of the resulting degradation products by ESI-MS/MS. The results showed that the drug was completely degraded with 0.1 N NaOH, 1 N HCl and 30 % hydrogen peroxide, while it was partially degraded by 0.1 N HCl, 3 % hydrogen peroxide and UV light. The hRf of SUL was 46 and the zone was completely separated from all obtained degradation products.

      Classification: 4e, 32e
      121 039
      Synthetic modification of 9?- and 9?-hydroxyparthenolide by Heck or acylation reactions and evaluation of cytotoxic activities
      A. EL BOUAKHER, B. JISMY, H. ALLOUCHI, E. DUVERGER, L. BARKAOUI, A. EL HAKMAOUI, R. DANIELLOU, G. GUILLAUMET, M. AKSSIRA* (*Laboratoire de Chimie Physique & de Chimie Bioorganique, Université Hassan II Casablanca, Mohammedia, Morocco; akssira@fstm.ac.ma)

      Planta Med. 83(07), 661-671 (2017). Structural modifications of 9α- and 9β-hydroxyparthenolide (isolated from Anvillea radiata aerial parts) were performed either by Heck’s reaction (a palladium(II) acetate treatment in presence of triethylamine and iodoaryl in dimethylformamide), or by acylation (here, addition of aroyl chlorides and/or acetic anhydride in dichloromethane and pyridine). TLC for reaction monitoring of the 21 derivatives on silica gel with petroleum ether – ethyl acetate in various proportions (3:2; 1:4; 1:1). Detection under UV or under white light after spraying with 5 % phosphomolybdic acid in ethanol, followed by heating.

      Classification: 8b, 15a, 32e
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