Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      124 058
      Development and validation of a high-performance thin-layer chromatographic method for the simultaneous estimation of torsemide and eplerenone by quality by design approach
      S. V. TATHE*, P.R. DESHMUKH, A.M. KASHID, S. GALKWAD (*Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune 41, Maharashtra, India, tatheshraddha09@gmail.com)

      J. Planar Chromatogr. 32, 411-420 (2019). HPTLC of torsemide (1) and eplerenone (2) on silica gel aluminum foil with toluene - ethyl acetate - glacial acetic acid 70:30:1. Quantitative determination by absorbance measurement at 297 nm. The hRF values for (1) and (2) were 24 and 50, respectively. Linearity was between 50 and 300 ng/zone for (1) and 125 and 1225 ng/zone for (2). Intermediate precision was below 2 % (n=3). The LOD and LOQ were 3 and 10 ng/zone for (1) and 2 and 7 ng/zone for (2), respectively. Recovery rate was between 102.6 and 108.8 % for (1) and (2).

      Classification: 32a
      124 016
      Quality by design-based optimization and validation of a high-performance thin-layer chromatography method for the estimation of rivaroxaban in bulk and its pharmaceutical dosage form
      A.S. KHURD*, K.V. DOSHI (*Department of Pharmaceutical Chemistry, Sinhgad Technical Education Society Sinhgad Institute of Pharmacy, Narhe, Pune 411041, Maharashtra, India, amrutakhurd@rediffmail.com)

      J. Planar Chromatogr. 32, 505-510 (2019). HPTLC of rivaroxaban on silica gel with toluene - methanol 7:3. Quantitative determination by absorbance measurement at 250 nm. The hRF value for rivaroxaban was 63. Linearity was between 100 and 600 ng/zone.  Intermediate precision was below 2 % (n=3). The LOD and LOQ were 3 and 9 ng/zone. Recovery rate was between 101 and 102.3 %.

      Classification: 32a
      124 065
      Design of experiment approach for the development and validation of a stability-indicating high-performance thin-layer chromatography method for the estimation of metformin hydrochloride and ursodeoxycholic acid in pharmaceutical dosage form
      R.K. PATEL*, V.K. SHAH (*Pharmaceutical Chemistry Department, K.B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat 382023, India, rajukpatel2006@gmail.com)

      J. Planar Chromatogr. 32, 481-493 (2019). HPTLC of metformin hydrochloride (1) and ursodeoxycholic acid (2) on silica gel with toluene - ethanol - acetone - formic acid 90:40:50:17. Quantitative determination by absorbance measurement at 234 and 700 nm for (1) and (2), respectively. The hRF values for (1) and (2) were 19 and 80, respectively. Linearity was between 5000 and 40000 ng/zone for (1) and 1500 and 12000 ng/zone for (2). Intermediate precision was below 1 % (n=3). The LOD and LOQ were 195 and 592 ng/zone for (1) and 150 and 455 ng/zone for (2), respectively. Recovery rate was 100.5 % for (1) and 99.9 % for (2).

      Classification: 32a
      124 022
      Simultaneous densitometric determination of aspirin and omeprazole by high-performance thin-layer chromatography
      A. KASHID*, O. KOLHE (*Department of Pharmaceutical Chemistry, Sinhgad Technical Education Society, Sinhgad Institute of Pharmacy, Narhe, Pune 41, India, arunkashid2006@gmail.com)

      J. Planar Chromatogr. 32, 501-504 (2019). HPTLC of aspirin (1) and omeprazole (2) on silica gel with ethyl acetate - dichloromethane - glacial acetic acid 80:20:1. Quantitative determination by absorbance measurement at 241 nm. The hRF values for (1) and (2) were 79 and 19, respectively. Linearity was between 160 and 960 ng/zone for (1) and 80 and 480 ng/zone for (2). Intermediate precision was below 1 % (n=3). The LOD and LOQ were 11 and 32 ng/zone for (1) and 3 and 8 ng/zone for (2), respectively. Recovery rate was between 101 and 106 % for both (1) and (2).

      Classification: 32a
      124 023
      Differences in the efficiency of separation of analgesic drugs by high-performance thin-layer chromatography with similar octadecyl silica-based adsorbents
      M. TRZEBIATOWSKI*, R. GWARDA, T. DZIDO (*Department of Physical Chemistry, Medical University of Lublin, Chodźki Str. 4A, 20-093 Lublin, Poland, michal-trzebiatowski@wp.pl)

      J. Planar Chromatogr. 32, 517-520 (2019). HPTLC of tramadol (1), caffeine (2), paracetamol (3), ibuprofen (4), naproxen (5), and diclofenac (6) on RP-18 WF, LiChrospher RP-18 WF, and RP-18 WF with concentration zone, developed with various ratios of methanol in water with 0.1 M potassium chloride. Qualitative identification under UV light at 254 nm. Potassium chloride may be used to suppress ion–ion interactions between the solutes and the silica gel surface.  HPTLC RP-18WF plates with concentration zone and developed with methanol - water 13:7 with addition of 0.15 mol/L KCl were suitable for the qualitative and quantitative analyses of tramadol, paracetamol, caffeine, naproxen, and ibuprofen or diclofenac. The method allowed to study subtle differences in the efficiency of the separation of analgesic drugs by HPTLC with similar octadecyl silica-based adsorbents.  

      Classification: 2c, 32a
      124 032
      Development and validation of different spectrophotometric and high-performance thin-layer chromatographic methods for the determination of fosinopril sodium, hydrochlorothiazide, and chlorothiazide as hydrochlorothiazide impurity
      M. ABDELRAHMAN, S. ADLY*, N. ALI, N. ABDELWAHAB (*Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmed Hegazy St., Beni-Suef 62514, Egypt, selvia.maged.adly@gmail.com)

      J. Planar Chromatogr. 32, 411-420 (2019). HPTLC of fosinopril sodium (1), hydrochlorothiazide (2), and chlorothiazide (3) on silica gel with ethyl acetate - chloroform - methanol - formic acid 120:80:10:1. Quantitative determination by absorbance measurement at 215 nm. The hRF values for (1) to (3) were 53, 39 and 29, respectively. Linearity was between 1 and 10 µg/zone for (1), 0.2 and 3 µg/zone for (2) and 0.2 and 2 µg/zone for (3).  Intermediate precisions were below 2 % (n=6). The LOD and LOQ were 280 and 860 ng/zone for (1), 90 and 350 ng/zone for (2) and 50 and 160 ng/zone for (3). Recovery rate was 100.2 % for (1), 100.1 % for (2) and 99.9 % for (3).

      Classification: 32a
      124 027
      HPTLC screening of weight loss products for deliberately added undeclared synthetic drugs
      Tiên DO*, E. REICH (*CAMAG Laboratory, Sonnenmattstrasse 11, 4132 Muttenz, Switzerland).

      J. AOAC Int. 102, 776-780 (2019). HPTLC of sibutramine, phenolphthalein, and
      three PDE5 inhibitors (sildenafil, vardenafil and tadalafil), as well as caffeine, fluoxetine, theophylline, and acetaminophen as adulterants in weight loss products on silica gel with methyl tert-butyl ether – toluene – methanol 8:2:1.
      Densitometric absorption measurement at 225 nm. The hRF values of reference substances increased in the following order: fluoxetine, sildenafil, vardenafil, caffeine, theophylline, tadalafil, acetaminophen, phenolphthalein and sibutramine.
      The method was successfully used for the screening of 12 commercial products. Of those, nine products tested positive for at least one undeclared component.

      Classification: 32a
      124 046
      Development of quantitative HPTLC-densitometry methods following a model process for transfer of TLC screening methods for pharmaceutical products containing moxifloxacin HCl, ofloxacin, amoxicillin trihydrate, acetylsalicylic acid + acetaminophen + caffeine, nimesulide, irbesartan, and pantoprazole
      B. ZENG (Zeng Bingsong), Y. GU (Gu Yiru), K. NGUYEN, J. SHERMA* (*Department of Chemistry, Lafayette College, 326 Hugel Science Center, 701 Sullivan Road, Easton, PA 18042, USA, shermaj@lafayette.edu)

      J. Liq. Chromatogr. Relat. Technol. 42, 324-329 (2019). HPTLC of individual pharmaceutical products containing moxifloxacin HCl (1), ofloxacin (2), amoxicillin trihydrate (3), acetylsalicylic acid + acetaminophen + caffeine (4), nimesulide (5), irbesartan (6), and pantoprazole (7) on silica gel with methanol - ammonium hydroxide - water 7:2:1 for (1), methanol - ethyl acetate - ammonium hydroxide 7:7:3 for (2), acetone - water - methanol - glacial acetic acid 20:10:5:2 for (3), ethyl acetate - glacial acetic acid 19:1 for (4), toluene - acetone 10:1 for (5), ethyl acetate - acetone - glacial acetic acid 180:40:1 for (6) and ethyl acetate - methanol - toluene 4:1:2 for (7). Quantitative determination by absorbance measurement at 366 nm. The hRF values for (1) to (3) and (5) to (7) were 72, 30, 80, 33, 40 and 43, respectively. The hRF values for (4) were 62 for acetylsalicylic acid, 49 for acetaminophen and 22 for caffeine. The quantitative methods were used to transfer the Global Pharma Health Fund (GPHF) Minilab Manual and U.S. Food and Drug Administration (FDA) Compendium to HPTLC following a model process for moxfloxacin HCl, ofloxacin, and amoxicillin trihydrate. The results met the guidelines of the model process regarding the calibration curves: r-values were at least 0.99, assays were within 85–115% specification limits of the label values of individual tablets and capsules, validation recoveries were within 95 - 105 % at all three spike levels, RSDs were no higher than 3 % for assays and validation analyses, and peak identity and peak purity checks had correlation factors of at least
      0.99. 
       

      Classification: 32a