Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
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Registered users can create a tailor made PDF of selected articles throughout CCBS search – simply use the cart icon on the right hand of each abstract to create your individual selection of abstracts. The saved items can be printed to PDF using the print function of your web browser.

      Thin-layer chromatography in medicinal chemistry
      Sandra SEGAN, D. OPSENICA, Dusanka OPSENICA* (*Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, P.O. Box 51, 11158 Belgrade, Serbia, dusankam@chem.bg.ac.rs)

      J. Liq. Chromatogr. Relat. Technol. 42, 238-248 (2019). Review of recent applications of TLC in medicinal chemistry, including the determination of lipophilicity of biologically active compounds and its influence as activity descriptors of absorption, distribution, metabolism, elimination and toxicity. Practical applications of TLC as a fast screening technique in different stages of monitoring processes were also described, including systems recently used for stability studies of selected drugs.

      Classification: 32a, 1a
      Simultaneous High-Performance Thin-Layer Chromatographic Quantification of withaferin A and withanolide A in Solanum nigrum L. "Black Nightshade"
      R. PREET*, R. GUPTA, M. KAUR (*Department of Botany, Punjabi University, Patiala, India, ramanbrar247@gmail.com)

      J. Planar Chromatogr. 32, 339-342 (2019). HPTLC of withanolide A (1) and withaferin A (2) on silica gel with toluene - ethyl acetate - formic acid - ethanol 60:30:1:6. Detection by spraying with p-anisaldehyde sulfuric acid (prepared by dissolving 1 mL of p-anisaldehyde solution in 2 mL of concentrated sulfuric acid and 100 mL of acetic acid). Quantitative determination by absorbance measurement at 530 nm. The hRF values for (1) and (2) were 43 and 55, respectively. 

      Classification: 32a
      Factor optimization study to develop and validate a reversed-phase Thin-Layer Chromatography method for the determination of trimetazidine dihydrochloride and its reported impurities in pharmaceuticals
      Suzan MAHMOUD SOLIMAN (National Organization for Drug Control and Research (NODCAR), El-Lagousa 51 Wezaret El-Ziraa St, Giza, Egypt, suzansoliman1961@hotmail.com)

      J. Planar Chromatogr. 32, 273-283 (2019). HPTLC of trimetazidine dihydrochloride (1) and its potential impurities, namely, piperazinecarboxaldehyde (2), trimethoxybenzyl alcohol (3), and trimethoxybenzaldehyde (4) on RP-18 with acetonitrile - methanol - 0.1 % aqueous ortho-phosphoric acid (pH 6.2) 9:9:2. Quantitative determination by absorbance measurement at 254 nm. The hRF values for (1) to (4) were 21, 35, 50 and 85, respectively. Linearity was between 0.05-10 µg/zone for (1), 0.05-1.1 µg/zone for (2), 0.05-1.2 µg/zone for (3) and 0.04-1.0 µg/zone for (4). The intermediate precision was below 2 % (n=9). The LOD and LOQ were 20 and 50 ng/zone for (1) to (3) and 15 and 40 ng/zone for (4), respectively. Recovery rate was 99.6 % for (1), 100.5 % for (2), 100.1 % for (3) and 99.4 % for (4).

      Classification: 32a
      Development of an analytical method for identification of the genotoxic impurity of quetiapine fumarate by High-Performance Thin-Layer Chromatography
      P. MINIYAR*, A. THOMAS, R. KULKARNI, S. KADAM, P. CHOUHAN, S. CHITLANGE (* Sinhgad Technical Education Society’s Sinhgad Institute of Pharmacy, Narhe, Pune – 411041, India miniyarpankaj@gmail.com)

      J. Planar Chromatogr. 32, 317-321 (2019). HPTLC of 2-chloroaniline (1) at trace levels
      in quetiapine fumarate (2) on silica gel with toluene and methanol 7:4. Quantitative determination by absorbance measurement at 235 nm. The hRF value of (1) was 85. Linearity was between 2.5-12.5 ng/zone for (1) and 400-2400 ng/zone for (2). The intermediate precision was below 2 % (n=3). The LOD and LOQ of (1) were 0.02 and 0.05 ng/zone for (1) [Editor´s note: This seems to be erroneous.] and 1.27 and 3.87 ng/zone for (2), respectively. Recovery rate ranged between 98 and 100 % for (1) and (2).

      Classification: 32a
      A developed High-Performance Thin-Layer Chromatographic method for the determination of orlistat in pharmaceutical preparations
      S. FATHY, A. IBRAHIM, E. ELTAMANY, J. BADR* (*Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt, jihanbadr2010@hotmail.com)

      J. Planar Chromatogr. 32, 329-334 (2019). HPTLC of orlistat on silica gel with chloroform - methanol 49:1. Detection by spraying with anisaldehyde - sulfuric acid, followed by heating at 120 °C for 5 min. Quantitative determination by absorbance measurement at 600 nm. The hRF value of orlistat was 75. Linearity was between 600 and 4000 ng/zone. The intermediate precision was below 2 % (n=6). The LOD and LOQ for orlistat were 140 and 466 ng/zone, respectively. Recovery rate was between 97.7 and 104.5 %.

      Classification: 32a
      High-Performance Thin-Layer Chromatographic method for the estimation of mirabegron and solifenacin succinate used in the treatment of overactive bladder syndrome
      D. SHAH*, P. TAHILRAMANI, V. PATEL, U. CHHALOTIYA (*Babaria Institute of Pharmacy, BITS Edu Campus, Vadodara-Mumbai NH#8, Varnama, Vadodara 391240, Gujarat, India, dimalgroup@yahoo.com)

      J. Planar Chromatogr. 32, 323-327 (2019). HPTLC of mirabegron (1) and solifenacin succinate (2) on silica gel with methanol - ethyl acetate - triethylamine 80:20:1. Quantitative determination by absorbance measurement at 222 nm. The hRF values for (1) and (2) were 76 and 56, respectively. Linearity was between 2.0-5.5 µg/zone for (1) and 0.4-1.1 µg/zone for (2). The intermediate precision was below 2 % (n=3). The LOD and LOQ were 34 and 103 ng/zone for (1) and 20 and 61 ng/zone for (2), respectively. Recovery rate was between 98.5 and 101.2 % for (1) and 99.2 and 100.8 % for (2).

      Classification: 32a
      Simultaneous estimation of empagliflozin and metformin by High-Performance Thin-Layer Chromatography using quality-by-design approach
      N. THAKOR*, S. AMRUTKAR, P. CHAUDHARI (*Department of Chemistry, PES Modern College of Pharmacy, Nigdi Pune, India, niyatee84@gmail.com)

      J. Planar Chromatogr. 32, 295-307 (2019). HPTLC of empagliflozin (1) and metformin (2) with ammonium acetate - methanol - acetonitrile - ethyl acetate 6:2:9:3. Quantitative determination by absorbance measurement at 254 nm. The hRF values for (1) and (2) were 49 and 81, respectivley. Linearity was between 2 and 10 µg/zone for (1) and 1 and 5 µg/zone for (2). The intermediate precision was below 2 % (n=3). The LOD and LOQ were 3 and 11 ng/zone for (1) and 110 and 331 ng/zone for (2), respectively. Recovery rate was between 98.4 and 99.8 % for (1) and 99.0 and 99.6 % for (2).

      Classification: 32a
      Different chromatographic methods for the determination of antidiabetic drugs in the presence of drug toxic impurity
      N. ABDELWAHAB, M. ADBELRAHMAN, J. BOSHRA*, A. TAHA (*Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef, 62514 Egypt, jon.maher@nub.edu.eg)

      J. Planar Chromatogr. 32, 309-316 (2019). HPTLC of vildagliptin (1) and metformin (2) in the presence of the toxic metformin impurity melamine (3) on silica gel with methanol - chloroform - formic acid 70:30:3. Quantitative determination by absorbance measurement at 215 nm. The hRF values for (1) to (3) were 78, 18 and 46, respectivley. Linearity ranged 0.2-2.6 µg/zone for (1), 0.4-4.5 µg/zone for (2) and 0.05-1.4 µg/zone for (3). The intermediate precision was below 2 % (n=3). The LOD and LOQ were 53 and 161 ng/mL for (1), 81 and 246 ng/mL for (2) and 15 and 48 ng/mL for (3), respectively. Recovery rate was 100.9 % for (1), 101.5 % for (2) and 99.2 % for (3). The results were compared statistically to the results obtained by a reported RP-HPLC method.

      Classification: 32a