Cumulative CAMAG Bibliography Service CCBS
Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.
The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:
- Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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J. Planar Chromatogr. 35, 519-532 (2022). HPTLC of binary mixtures of the novel oral anticoagulants (NOACs) apixaban (1), edoxaban tosylate (2) and rivaroxaban (3) with the lipid-lowering statin, rosuvastatin calcium (4) on silica gel with toluene - ethyl acetate - methanol - 25 % ammonia 35:45:20:2 (method 1) for the three mixtures, and methanol - 25 % ammonia 199:1 (method 2) for (2)/(3) mixture only. Quantitative determination by absorbance measurement at 291 nm. The hRF values for (1) to (4) were 65, 20, 75 and 10 using method 1, and 40 for (2) and 90 for (4) using method 2. Linearity was between 5 and 45 µg/mL for (1) to (4). Interday and intra-day precisions were below 3 % (n=6). The LOD and LOQ were 0.1 and 0.4 µg/mL for (1), 1 and 4 µg/mL for (2) and (3), 0.4 and 1 µg/mL for (4) using method 1, and 1.4 and 4.7 µg/mL for (2) and 0.4 and 1.2 µg/mL for (4) using method 2. Average recovery was between 97.6 and 102.9 % for (1) to (4).
J Chromatogr Sci, 60 (9), 832-839 (2022). Establishment of two TLC methods for the synchronous estimation of cinnarizine (Cinn) and acefyline heptaminol (Acef) in the presence of reported Cinn/Acef degradation products, as well as theophylline (Theo) as potential impurity of Acef. TLC on silica gel (1) for Cinn with dichloromethane - methanol - formic acid 30:2:1 and (2) for Acef with the same solvents in ratio 150:7.5:4. Quantitative determination by densitometry at 254 nm showed that Cinn and Acef are well separated from their degradation products. The concentration range was 0.2 - 1.8 and 2 - 18 μg/zone for Cinn and Acef, respectively, with mean percentage recoveries of 99.2 / 99.8 and 99.2 / 99.7 for method 1 and method 2, respectively. The method is selective, robust and retained its accuracy in up to 50 % of Cinn/Acef reported degradation products and Theo. Application of the two methods to a coformulated drug product comprising Cinn and Acef with satisfactory results showing statistically no significant differences compared with those obtained by reference ones.
J Chromatogr Sci, 60 (10), 946 - 952 (2022). Study of the mechanism of micellar thin layer chromatography (MTLC) and development of a new simple and sensitive method for simultaneous separation of empagliflozin, linagliptin and metformin hydrochloride ternary mixture. TLC using a micellar mobile phase composed of methanol and aqueous solution of each of three different surfactants, sodium dodecyl sulphate (SDS), benzalkonium chloride (BAC) and polysorbate 80 (tween 80), in ratio of 2:3. Micellar TLC determination at 237 nm. Investigation of the quantitative structure - retention relationships by modeling, evaluating and validating with a molecular operating environment software. Discussion of the basis for selecting surfactants, for example the separation using SDS (anionic surfactant) and BAC (cationic surfactant) depended on ionization potential (AMI-IP), partition coefficient (logP (o/w)) and hydrogen bond donor atoms (a-don), whereas the separation using tween 80 depended mainly on the lipophilicity (RM0), solvation energy (E-sol) and Van der Waals energy (E-vdw).
J Chromatogr Sci, 60 (6), 606-612 (2022). Simultaneous determination of sofosbuvir and daclatasvir, co-formulated as directly acting antiviral agents used for treatment of hepatitis C virus, by TLC on silica gel with ethyl acetate - hexane - methanol 18:1:1. Both substances were quantitatively separated in one analytical run. Quantitative determination by densitometry at 280 nm with linearity range of 0.4 - 25.4 μg/band for sofosbuvir and 0.4 - 12.8 μg/band for daclatasvir. The method is time- and cost-saving, which is even more important for some combinations on the market, such as Darvoni® tablets.
J. Chromatogr. Sci. 60 (3), 267-273 (2022). HPTLC for the selective detection of the diuretic drug triamterene in pure form, tablets and human plasma, on silica gel with ethyl acetate - dimethylformamide - ammonia 70:27:3. Quantitative determination by fluorescence measurement at 440 nm improved the method sensitivity 250-fold compared with previously reported studies, and enabled the detection of triamterene in the linear concentration range of 0.8 to 60 ng/band for the pure drug and 1.0 to 60 ng/band for biological samples (human plasma).
J. Planar Chromatogr. 35, 73-81 (2022). HPTLC of omeprazole (1) and its impurity 4‑methoxy‑2‑nitroaniline (1) on silica gel with methanol - n-hexane - ethyl acetate 1:10:11. Quantitative determination by absorbance measurement at 291 and 223 nm for (1) and (2), respectively. The hRF values for (1) and (2) were 25 and 89, respectively. Linearity was between 100 and 500 ng/zone for (1) and 10 and 50 ng/zone for (2). Interday and intra-day precisions were below 1 % (n=3). The LOD and LOQ were 3.2 and 9.8 ng/zone for (1) and 0.41 and 1.25 ng/zone for (2), respectively. Recovery was in the range of 98-102 % for (2).
J. Planar Chromatogr. 34, 455-466 (2021). HPTLC of mometasone furoate (1) and salicylic acid (2) on silica gel with chloroform - ethanol 9:1. Quantitative determination by absorbance measurement at 250 nm for (1) and 300 nm for (2). The hRF values for (1) and (2) were 13 and 93, respectively. Linearity was between 100 and 1600 ng/zone for (1) and 400 and 5000 ng/zone for (2). LOD and LOQ were 16 and 47 ng/zone for (1) and 7 and 20 ng/zone for (2), respectively. Intermediate precisions were below 2 %. Recovery was between 98 and 102 %.
J. Planar Chromatogr. 34, 467-477 (2021). HPTLC of five antihypertensive drugs, atenolol (1), amlodipine (2), losartan (3), hydrochlorothiazide (4), and telmisartan (5) on silica gel with chloroform - toluene - methanol - acetone - formic acid 400:300:150:260:3. Quantitative determination by absorbance measurement at 254 nm. The hRF values for (1) to (5) were 7, 12, 45, 56 and 64, respectively. Linearity ranged from 1-25 μg/zone for (1), (3) and (5) and 1-20 μg/zone for (2) and (4). LOD and LOQ were 300 and 900 ng/zone for (1), 130 and 420 ng/zone for (2), 230 and 690 ng/zone for (3), 140 and 430 ng/zone for (4) and 190 and 560 ng/zone for (5). Intermediate precisions were below 1 % (n=9). Mean recovery was 99.3 % fo (1), 100.1 % for (2), 99.7 % for (3), 99.7 % for (4) and 100.3 % for (5).