J. Liq. Chrom. & Rel. Technol. 26, 3307-3314 (2003). HPTLC of rosiglitazone( (+/-)-5-[4-[2-[N-methyl-N-(2-pyridinyl)amino]-ethoxy]benzyl]-2,4-thiazolidinedione maleate) on silica gel with chloroform - ethyl acetate - 25% NH3 50:50:1. Detection and quantitation by densitometry in the reflectance/absorbance mode at 240 and 245 nm. Precision expressed as mean RSD was 3.58 and 2.76% for 240 nm, and 8.23 and 6.56% for 254 nm; mean recoveries from the fortified samples ranged from 89.48% to 99.38% for 240 nm, and from 89.05% to 100.89% for 254 nm. The mean recoveries from tablets were 101.95% to 103.2% for assays at 240 and 254 nm, respectively. New, simple, rapid method.

CBS 84, 12-13 (2000) HPTLC of synthesis product SR 94163 and impurities SR 94145 and SR 94454. Quantitative determination at 210 nm. Recovery rate for impurities is 98-114 %. For routine analysis in process control the HPLC method was substituted by the faster HPTLC method.

J. AOAC Int. 86, 935-940 (2003). TLC of indapamide (4-chloro-N-(2-methylindolin-1-yl)-3-sulfamoylbenzamide), its degradation product, and related substance 2-methylnitrosoindoline on silica gel using toluene - ethyl acetate - glacial acetic acid 69:30:1 after pre-saturation for 1 h. Detection under UV light at 254 nm. Quantitative determination at 424 nm. Limit of detection 0.11 µg/spot. The method was validated according to the guidelines of the USP.

J. Planar Chromatogr. 17, 154-156 (2004). HPTLC of pioglitazone hydrochloride ((±)-5-{p-[2-(5-ethyl-2-pyridyl)-ethoxy]benzyl}-2,4-thiazolidinedione hydrochloride) and glimepiride (trans-3-ethyl-2,5-dihydroxy-4-methyl-N-[2-[4-[[[[(4-methylcyclohexyl)amino]-carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide)and atorvastatin as internal standard on silica gel after pre-washing in a twin-trough chamber after pre-saturation with toluene - methanol - ethyl acetate - formic acid 70:20:15:0.1. Evaluation by densitometry at 235 nm.

IPC 56th 2004, Abstract No. G-20. Simultaneous HPTLC determination of loratadine and ambroxol in combined dosage form on silica gel with n-hexane - dichloromethane - triethanolamine 11:8:1.The Rf value of loratadine and ambroxal was found to be 0.40 and 0.16 respectively. Quantitative evaluation by scanning at 254 nm.The method was linear in the range of 0.2 -1 mg/spot for loratadine and 1.2 - 6 mg/spot for ambroxol with recovery of 98.2 - 98.5 %. The method was validated for accuracy, precision, linearity, specificity, LOD, and LOQ.

56th IPC 2004, Abstract No. GP-47. Stability indicating HPTLC determination of oxcarbazepine in tablet dosage form on silica gel with toluene - methanol 4:1. The Rf value of oxcarbazepine was 0.17. Quantitative determination by scanning at 255 nm. The compound was subjected to acid and alkali hydrolysis, oxidation, dry heat, and photo degradation. All degraded products were well resolved from the pure drug. The method was validated for accuracy, precision, linearity, robustness, and recovery.

J. Pharm. Biomed. Anal. 39, 581-586 (2005). For post-production quality control of camptothecin derivatives irinotecan (CPT 11) and topotecan (TPT), HPLC and HPTLC methods have been developed which were suitable for identification, determination of purity and quantification. HPTLC on silica gel with methylene chloride - methanol - formic acid - water 82:24:2:1. After development, the plate was soaked in 15 % paraffin in n-heptane. Quantitative determination by fluorescence measurement at 366/>400 nm. The method was linear within the range of 100-1000 ng/mL for both CPT-11 and TPT. The method was validated for accuracy, precision, LOD, and LOQ.

Abstract GP-18, IPC (2005). HPTLC of nimesulide and chlorzoxazone in tablets on silica gel (prewashed with methanol) with toluene - acetone - ammonia 50:50:4. Paracetamol was used as internal standard. Quantitative determination by absorbance measurement at 265 nm. Nimesulide, chlorzoxazone and paracetamol showed hRf values of 80, 73 and 42, respectively. Linearity was obtained between 0.2-1.0 mg/mL with recovery rates of 99.6-100.3 % for both compounds.The method was validated for accuracy, precision, linearity, LOD, and LOQ.