Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      100 110
      High-Performance Thin-Layer Chromatographic determination of etoricoxib in the bulk drug and in pharmaceutical dosage form
      G. MAHESHWARI, G.S. SUBRAMANIAN*, A. KARTHIK, A. RANJITHKUMAR, P. MUSMADE, K. GINJUPALLI, N. UDUPA (*Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576104, India; ganrajesh@gmail.com).

      J. Planar Chromatogr. 20, 335-339 (2007). TLC of etoricoxib (rofecoxib as internal standard) on silica gel in a filter-paper-lined twin-trough chamber previously saturated with mobile phase vapor for 30 min with toluene - 1,4-dioxane - methanol 17:2:1. Densitometric analysis of etoricoxib was performed in absorbance mode at 235 nm. The limits of detection and quantitation were 30 and 100 ng/zone, respectively.

      Classification: 32a
      100 145
      Validation of a High-Performance Thin-Layer Chromatographic method, with densitometric detection, for quantitative analysis of nebivolol hydrochloride in tablet formulations
      T.S. REDDY, P.S. DEVI* (*Analytical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, India; sitadevi@iictnet.org)

      J. Planar Chromatogr. 20, 149-152 (2007). HPTLC of nebivolol hydrochloride on silica gel prewashed with methanol with toluene - ethyl acetate - methanol - formic acid 8:6:4:1 in a saturated twin-trough chamber. Densitometric quantification at 285 and 298 nm.

      Classification: 32a
      101 048
      Optimization of the visualization of steroids separated by OPLC
      Boglárka BAGÓCSI*, Z. VÉGH, K. FERENCZI-FODOR (*Gedeon Richter, H-1475 Budapest, 10, Box 27, Hungary; b.bagocsi@richter.hu)

      J. Planar Chromatogr. 21, 107-112 (2008). Optimization and comparison of the acidic visualization methods most often used for steroids. OPLC of ethinyl estradiol, ’dienolether’ (3-methoxyestra-2,5(10)-dien-17b-ol), norethisterone, norethisterone acetate, norethisterone enanthate, nandrolone, and nandrolone decanoate on HPTLC silica gel with cyclohexanone - ethyl acetate - chloroform 1:1:1. Detection with sulfuric acid at three different concentrations, phosphomolybdic acid, and phosphoric acid with different heating temperatures for different times. Evaluation under UV 366 nm (sulfuric acid, phosphoric acid) and in white light (phosphomolybdic acid). It was found that derivatization at higher temperatures for shorter periods usually results in greater sensitivity, although heating for longer periods at lower temperatures leads to a more stable and robust result. Evaluation by videodensitometry.

      Classification: 32a
      102 090
      High performance thin layer chromatographic determination of the related substances in alprazolam drug
      Y. ANJANEYULU*, R. MARAYYA, D. LINGA RAO, P. KRISHNA RAO (*Natco Pharma Ltd. QC / QA Chemical Div., Road No.2, Banjara Hills, Hyderabad 500033, India, mekaguda@natcopharma.co.in)

      Asian J. Chem. 19(5), 3375-3381 (2007). The TLC method described in USP 28 does not separate all the related substances of alprazolam. An alternative HPTLC method is described for separation and estimation of starting material and synthesis related intermediates in alprazolam: 2-chloro acetamide-5-chloro benzophenone (impurity 1) i.e. starting material, nordiazepam (impurity 2), thionordiazepam (impurity 3), 2-(2-aceto hydrazinyl)-7-chloro-5-phenyl-3H-1, 4-benzodiazapine (impurity 4). The hRf values of alprazolam, impurity 4, impurity 3, impurity 2, and impurity 1 were 25, 16, 77, 45, and 83 respectively. The HPTLC method developed is capable of detecting impurities at a level of 0.05%.

      Classification: 32a
      102 115
      HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF RABEPRAZOLE SODIUM AND ITOPRIDE HYDROCHLORIDE IN CAPSULE AND BULK DRUG
      S. Mageswari*, K. Surendra, R. Maheswari, N. Krishnan, C. Roosewelt, V. Gunasekaran (*Dept. of Pharmaceutical Analysis, Vel’s College of Pharmacy, Pallavaram, Chennai 600117, India, kalavaivgs30@rediffmail.com)

      Asian J. Chem. 19(7), 5634-5638 (2007). TLC of rabeprazole sodium and itopride hydrochloride on silica gel prewashed with methanol, with toluene - chloroform - methanol - 25 % ammonia 5:6:2. Quantitative determination by absorbance measurement at 225 nm. Linearity was between 120 and 280 µg/mL for rabeprazole sodium and 900 and 1900 µg/mL for itopride hydrochloride. The recovery (by standard addition method) was between 98.1 and 99.5 % for both drugs. The proposed method is precise and accurate and can be used for routine analysis of rabeprazole sodium and itopride hydrochloride in capsule formulation.

      Classification: 32a
      102 136
      A VALIDATED HPTLC METHOD FOR DETERMINATION OF ONDANSETRON IN COMBINATION WITH OMEPRAZOLE OR RABEPRAZOLE IN SOLID DOSAGE FORM
      P. Raval*, Manisha Puranik, S. Wadhera, P. Yeole (*P.G. Dept. of Q.A., Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha 42001, India)

      Ind. J. Pharm. Sci. 70(3), 386-390 (2008). HPTLC for the simultaneous estimation of ondansetron combinations in solid dosage form with omeprazole and rabeprazole, on silica gel with dichloromethane - methanol 9:1. Quantitative determination by absorbance measurement at 309 nm for combinations of ondansetron with omeprazole and at 294 nm for ondansetron with rabeprazole. The hRf value of ondansetron and omeprazole was 42 and 54, respectively, while for ondansetron and rabeprazole hRF values were 41 and 51 respectively. Linearity was between 100 and 500 ng/spot for three drugs. The method can be employed for routine quality control of such formulation.

      Classification: 32a
      102 156
      Simultaneous estimation of levofloxacin hemihydrate and ornidazole in tablet dosage form by HPTLC
      K. SURENDRA*, S. Mageswari, R. Maheswari, N. Harikrishnan, C. Roosewelt & V. Gunasekaran (*Dept. of Pharmaceutical Analysis, Vel’s College of Pharmacy, Chennai 6000117, India, kalavaivgs30@rediffmail.com)

      Asian J. Chem. 19(7), 5647-5651 (2007). HPTLC of levofloxacin hemihydrate and ornidazole on silica gel with n-butanol - water - acetic acid 3:1:1. Quantitative determination by absorbance measurement at 366 nm. The method was linear in the range of 1050-1400 µg/mL and 2600-2900 µg/mL for levofloxacin and ornidazole respectively. The recovery was between 97.3 and 98.0 % for both drugs. The method was suitable for simultaneous estimation of both drugs in combined tablet dosage form.

      Classification: 32a
      103 109
      RP-TLC determination of the lipohilicity of 1-substituted pyrrolidin-2-one derivatives
      Katarzyna KULIG*, B. MALAWSKA (*Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland; mfkkulig@cyf-kr.edu.pl)

      Correlation of lipophilicity with affinity for alpha-adrenoceptors. J. Planar Chromatogr. 22, 141-144 (2009). Determination of the relative lipophilicity of 14 1-substituted pyrrolidin-2-one by TLC on RP-18 with mixtures of acetonitrile and pH 7.0 Tris buffer with volume fractions of acetonitrile between 20 and 80 %, with chamber saturation for 2 h. Detection under UV light. Retention data obtained by this method were exponentially dependent on acetonitrile concentration and enabled estimation of the relative lipophilicity corresponding to pH 7.0 Tris buffer as mobile phase.

      Classification: 32a