59th Indian Pharmaceutical Congress F-95, 414, (2007). HPTLC of granisetron hydrochloride on silica gel aluminium plates with chloroform - methanol 4:1, with 0.1 mL of ammonia. The hRf value of granisetron hydrochloride was 42. Densitometry in absorbance mode at 301 nm. Linearity was between 400 and 1600 ng/zone. The limit of detection and quantification was 80 ng and 160 ng/zone, respectively. The drug was subjected to acid and alkali hydrolysis, oxidative and thermal degradation. The degration products were well separated from the main compound.

J. Planar Chromatogr. 20, 463-475 (2007). TLC of chlorpromazine hydrochloride, trifluoperazine dihydrochloride, promazine hydrochloride, and doxepin hydrochloride on silica gel with 1-butanol - aqueous ammonia solution 5:1 or cyclohexane - acetone - diethylamine 8:1:1 after saturation with mobile phase vapor. Detection by inspection under UV light at 254 nm. Scanning densitometry was performed at 254 nm and at the wavelengths of maximum absorbance of the substances.

59th Indian Pharmaceutical Congress F-55, 402, (2007). HPTLC of metformin hydrochloride on silica gel with methanol - chloroform - ammonium acetate 6:3:1. Densitometry at 236 nm. The method has a range from 100 - 300 ng/zone. The limit of detection and quantification was 25 ng and 100 ng/zone, respectively. The method was applied for analysis of metformin hydrochloride in multi-component formulations containing glipizide, gliclazide and glibenclamide as well as in serum.

Arzneim.-Forsch./Drug Res. 56, 753-759 (2006). TLC of twelve new 5-aryl-1H-pyrrole analogs of celecoxib on silica gel with chloroform - ethanol 20:3 and ethanol - chloroform - toluene - 0.5 M ammonium acetate 6:6:6:1. Detection under UV 254 nm.

Asian J. Chem. 19(2), 1487-1493 (2007). TLC of ambroxol HCl and cetirizine HCl on silica gel with methanol - ethyl acetate - toluene - ammonia 3:10:12:1. Quantitative determination by absorbance measurement at 231 nm. The hRf value of ambroxol HCl was 78 and of cetirizine HCl 40. The calibration curve response was observed between 4 and 10 µg for ambroxol HCl and 0.4 and 0.8 µg for cetirizine HCl via peak height and area. The percent drug estimated for ambroxol HCl and cetirizine HCl from marketed formulation was 99.9, 100.2 by height and 100.8, 99.1 by area respectively. Recovery of ambroxol HCl via peak height and via peak area was 102.7 and 100.0 % respectively, and for cetirizine HCl 99.3 and 98.1 %.

Asian J. Chem. 19(7), 5582-5586 (2007). HPTLC of telmisartan and hydrochlorothiazide on silica gel with ethyl acetate - chloroform - methanol 10:3:1. Absorbance measurement at 270 nm. The method was linear in the range of 500-750 ng/µL and 1600-2400 µg/µL for hydrochlorothiazide and telmisartan respectively. The recovery was 99.4-99.6 % for both compounds.

J. Liq. Chromatogr. Relat. Technol. 31, 1204-1212 (2008). HPTLC of mirtazapine (1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,3-c][2-benzazepine]), and three impurities (2-(4-methyl-2-phenyl-piperazin-1-yl)nicotinic acid, [2-(4-methyl-2-phenyl-piperazinyl)-pyridin-3-yl]methanol, and 2-chloronicotinic acid on silica gel with toluene - acetone - methanol 6:2:2 with chamber saturation. Quantitative determination by absorbance measurement at 285 nm. The limit of detection and quantification for mirtazapine was 22 and 75 ng/spot, respectively.

Ind. J. Pharm. Sci. 69 (5), 689 - 686 (2007). A simple, fast precise and accurate HPTLC method has been developed for the simultaneous estimation of lansoprazole and domperidone in tablet formulations. This method allows the determination of 100-500 ng/spot of lansoprazole and 100-500 ng/spot of domperidone. HPTLC on silica gel with n-butanol - acetic acid - water 36:12:1:2. Quantitative determination by absorbance measurement at 288 nm. The hRf value of lansoprazole was 78 and of domperidone 21. The limit of detection and quantification for lansoprazole was 10 ng/spot and 40 ng/spot, and for domperidone 30 ng/spot and 65 ng/spot, respectivey. The method was suitable for routine quality control.