Part 1. Lipophilicity of pyrimido[5,4-c]quinolin-4(3H)-ones and 1,2,3,4-tetrahydropyrimido[5,4-c]quinolin-2,4-diones. J. Planar Chromatogr. 15, 169-175 (2002). Determination of the lipophilicity of new bioactive pyrimido[5,4-c]quinolin-4(3H)-ones and 1,2,3,4-tetrahydropyrimido[5,4-c]quinolin-2,4-diones by RP-TLC with DMF-TRIS buffer. TLC of nine derivatives of N-3-substituted 2-methylpyrimido[5,4-c]quinolin-4(3H)ones and three derivatives of 1,2,3,4-tetrahydropyrimido[5,4-c]quinolin-2,4-diones on RP-18. Detection under UV. Experimental lipophilicity was determined by the use of calibration curves obtained under same measurement conditions for a set of six standards of known experimental lipophilicity.

J. Planar Chromatogr. 15, 410-413 (2002). TLC of nicotinic acid and derivatives (methyl nicotinate, ethyl nicotinate, isopropyl nicotinate, butyl nicotinate, hexyl nicotinate, benzyl nicotinate, nicotinamide, N-methylnicotinamide, N,N-diethylnicotinamide) on silica gel and silica gel kieselguhr with mixtures of acetone and n-hexane in different volume proportions, on RP silica gel with methanol - water 9:1, 8:2, and 7:3, on polyamide 11 with mixtures of benzene and methanol. Detection under UV 254 nm.

Proc. Intern. Symp. on Planar Separations Plan. Chrom. 181-184 (2003). TLC of myorelaxants (atracurium besylate, pancuronium bromide, rocuronium chloride, suxamethonium chloride, vecuronium bromide) on cellulose with water - ethanol and water - propanol, varying the concentration of the organic modifier from 30 to 70 vol % of ethanol, as well as from 10 to 90 vol % of propanol. Detection by exposure to iodine vapor.

J. Planar Chromatogr. 16, 433-437 (2003). TLC of prenylamine, lidoflazine, bepridil hydrochloride, and fendiline hydrochloride on RP-8 and RP-18 altering the pH and the concentration of organic modifier (methanol, ethanol, tetrahydrofuran, acetonitrile) in the aqueous phase. On RP-8 the best separation was achieved with 50% acetonitrile in pH 2.06 phosphate buffer and on RP-18 with 50% ethanol in pH 2.06 phosphate buffer. Detection under 254 nm and videodensitometric determination. New TLC procedure.

CBS 87, 4-5 (2001). HPTLC on silica gel with ethyl acetate - chloroform - methanol 6:4:1. Detection by dipping in fluorescamine solution. Quantitative determination by fluorescence measurement at 365/>400 nm.

Indian J. Pharm. Sci. 66 (3), 283-286 (2004). TLC of lamotrigine in its tablet dosage form on silica gel with acetone - toluene - ammonia 14:6:1. Quantitative determination by absorbance measurement at 312 nm. The method was quantitatively evaluated in terms of linearity, accuracy, precision, repeatability, and specificity to prove its utility in the analysis of tablet dosage form.

J. Planar Chromatogr. 17, 164-168 (2004). HPTLC of flupirtine maleate on silica gel with ethyl acetate - methanol - 25 % ammonia 17:2:1 in a saturated developing chamber. Then the developed plate must be dipped for 2 s in 1:3 paraffin - hexane. Dipping increases the fluorescence tenfold and preserves the fluorescence stability for hours. Presentation of a new formula for transforming fluorescence measurements in accordance with Kubelka-Munk theory. The fluorescence signals, the absorption signals, and data from a selected reference are combined in one expression. Only diode-array techniques can measure all the required data simultaneously. The fluorescence calibration curve was linear over the range 300 to 5000 ng per spot.

IPC 56th 2004, Abstract No. GP-17. HPTLC of mirtazapine in tablet dosage form on silica gel with chloroform - methanol 1:9. The Rf value was 0.50 - 0.52, the linearity range was 0.3 - 1.5 mg/spot. Quantitative determination by scanning at 295 nm. The method was validated for accuracy, precision, linearity, specificity, LOD, and LOQ.