Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      111 099
      Application of an expanded model procedure for transfer of TLC screening for substandard and fake drugs designed for use in developing countries to quantitative HPTLC-densitometry methods
      K. LIANZA, J. SHERMA* (*Department of Chemistry, Lafayette College, Easton, PA, USA, shermaj@lafayette.edu)

      J. Liq. Chromatogr. Relat. Technol. 36, 2446-2462 (2013). HPTLC of amitriptyline in tablets on silica gel with acetone - ammonium hydroxide 99:1. Quantitative determination by absorbance measurement at 254 nm. The hRf value of amitriptyline was 46. Linearity was 0.70-1.30 µg/zone. The earlier model TLC to HPTLC-densitometry transfer procedure was expanded by adding sample peak identification confirmation and peak purity (specificity) tests.

      Classification: 32a
      113 084
      Use of a model procedure for transfer of Minilab qualitative screening TLC methods for lumefantrine and artemether in a combined tablet formulation to individual and simultaneous quantitative HPTLC-densitometry methods
      M. NGUYEN, J. SHERMA* (* Department of Chemistry, Lafayette College, Easton, PA 18042, USA)

      Trends in Chromatography 8, 131-135 (2013). Based on the Minilab TLC screening methods two individual and one simultaneous HPTLC methods for quantification of lumefantrine and artemether were developed. HPTLC of artemether, lumefantrine, and both substances in a combined tablet formulation on silica gel with ethyl acetate - glacial acetic acid - toluene 2:1:9 with chamber saturation. Quantitative absorbance measurement of lumefantrine at 254 nm. For artemether, detection by spraying with methanol - 96 % sulfuric acid 19:1 and heating at 100 °C for 5 minutes, evaluation in daylight and quantitative absorbance measurement at 610 nm. With the simultaneous method artemether zones were detected by heating at 160 °C for 5 min, and after cooling absorbance measurement at 254 nm was performed. This is a novel, reagent-free detection method based on thermochemical activation of fluorescence quenching. Precision (%RSD) for the artemether individual method was 0.1-0.6 % and recovery 98-103 %. Precision (%RSD) for the lumefantrine individual method was 0.9-1.8 % and recovery 100-102 %. With the simultaneous method the hRF was 34 for lumefantrine and 61 for artemether, precision (%RSD) was below 3 % and recovery was 98-100 %.

      Classification: 32a
      115 065
      Determination of moxonidine and its impurities by thin-layer chromatography
      Slavica FILIPIC, M. SHENGER, Katarina NIKOLIC, Danica AGBABA* (*Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia, danica@pharmacy.bg.ac.rs)

      J. Liq. Chromatogr. Relat. Technol. 38, 1121-1125 (2015). HPTLC of moxonidine and impurities (1) to (4) in dosage forms on silica gel with methanol - toluene - dichloromethane - ammonia 20:30:20:1. Quantitative determination by absorbance measurement at 260 and 280 nm. Average migration distances for moxonidine and its impurities (1) to (4) were 58.5 mm, 64.4 mm, 34.5 mm, 16.1 mm and 25.6 mm, respectively. Linearity was in the range of 200-600 ng/zone for moxonidine and 20-200 ng/zone for impurities (1) to (4). LOD and LOQ for impurities (1) to (4) were 7 and 20 ng/zone. The intermediate precisions were below 4 % (n=6). Recoveries ranged between 90 and 108 %.

      Classification: 32a
      117 113
      Development and validation of a stability-indicating assay method for naftopidil
      S. EZHAVA*, S. SHAH, A. PATWARI, M. CHHABRIA (*College of Pharmacy,
      Navrangpura, Ahmedabad 380 009, India, sindhulmcp@gmail.com)

      J. Planar Chromatogr. 29, 195-202 (2016). HPTLC of naftopidil on silica gel with toluene – ethyl acetate – methanol – triethylamine 80:20:5:3. Quantitative determination by absorbance measurement at 254 nm. The hRF value was 52. Linearity was in the range of 500-2500 ng/zone. Intermediate precisions were below 1.5 %. The LOD and LOQ were 95 and 268 ng/zone. Average recovery was 100.0%.

      Classification: 32a
      119 099
      Development and validation of a HPTLC method for analysis of sunitinib malate
      M. HAJMALEK, M. GOUDARZI, S. GHAFFARI, H. ATTAR, M. GHANBARI* (*Research &
      Development Department, Tofigh Daru Research and Engineering Company, Tehran, Iran, s.ghaffari@todaco.com)

      Braz. J. Pharm. Sci. 52, 595-601 (2016). HPTLC of sunitinib malate on silica gel with dichloromethane – methanol – toluene – ammonia 5 % 60:30:10:1. Quantitative determination by absorbance measurement at 430 nm. The hRF value for sunitinib was 53. Linearity was between 27 and 437 ng/zone. LOD and LOQ were 23 and 70 ng/zone. The intermediate precision was <3 % (n=3). Recovery rate was between 93.5 and 100.9 %.

      Classification: 32a
      122 064
      Quantitative determination of synthesized genotoxic impurities in nifuroxazide capsules by validated chromatographic methods
      N. ABDELWAHAB, N. ALI, M. ZAKI*, M. ABDELWAKY, M. EL-SAADI (*Beni-Suef University, Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department, Alshaheed Shehata Ahmed Hegazy St, 62514 Beni-Suef, Egypt, marcomounir11@yahoo.com)

      J. AOAC Int. 101, 385-393 (2018). HPTLC of nifuroxazide and its impurities A, B, C and D on silica gel with ethyl acetate – acetone – methanol – ammonia 170:50:10:1. Quantitative determination by absorbance measurement at 230 nm. The hRF values for nifuroxazide and its impurities A, B, C and D were 67, 46, 86, 8 and 34, respectively. Linearity ranged between 10-100 μg/zone for nifuroxazide and 0.1-1.0 μg/zone for impurities A to D. LOD and LOQ were 28 and 84 ng/zone for A, 27 and 80 ng/zone for B, 24 and 73 ng/zone for C and 26 and 79 ng/zone for D. The intermediate precision was <1 % (n=3). Average recovery was 100.5 % for nifuroxazide, 100.2 % for A, 99.0 % for B, 100.0 % for C and 100.2 % for D.

      Classification: 28a, 32a
      55 125
      Liquid chromatographic determination of aspartame in dry beverage bases and sweetener tablets with confirmation by thin-layer chromatography
      D. DANIELS, F. JOE, C. WARNER, T. FAZIO

      J.A.O.A.C. 67, 513-515 (1984). TLC of aspartame (N-alpha-aspartyl phenylalanine 1-methylester) in dry beverage bases and sweetener tablets on silica with butanol- acetic acid - water 4:1:1. Ninhydrin as spray reagent.

      Classification: 32a
      56 160
      A simple reversed phase TLC method for stability-indicating assay of digoxin
      J. MEZEI, J. PAP

      Acta Pharmaceutica Hungarica 55, 134-137 (1985). Silica layers sprayed with 5 % paraffin oil solution in petrol ether and dried at room temperature. Development with methanol - water 55:45. Visualization by spraying with xanthydrol reagent and heating at 60°C.

      Classification: 32a