Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

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      127 002
      Low temperature plasma probe mass spectrometry for analytes separated on thin-layer chromatography plates: direct vs. laser assisted desorption.
      X. GONG, D. ZHANG, I. B. EMBILE, Y. SHE, S. SHI, G. GAMEZ* (*Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA; gerardo.gamez@ttu.edu)

      J Am Soc Mass Spectrom 31(9), 1981-1993 (2020). Low-temperature plasma-mass spectrometry was studied for comparison between direct desorption (DD) and diode laser assisted desorption (LD) in terms of quantitative and qualitative analysis of compounds from cellulose vs. silica gel TLC layers. Compounds (the 20 common amino acids, propofol, nicotine, cotinine, salicylamide, acetylsalicylic acid, paracetamol, caffeine, valprolactone and its isomer 4-ene-valproic acid) were applied on the TLC plates (without development) at different concentrations; a commercial mixture of acetylsalicylic acid, paracetamol and caffeine was also applied on TLC plates, developed with dichloromethane – ethyl acetate 1:50, detection at UV 254 nm and quantitative MS. In general, DD provided good results on cellulose, where LODs where between 0.01 and 2.55 ng/mm2, whereas several compounds remained undetected on silica gel. LD however provided LODs on silica gel from 0.3 to 84 pg/mm2. Tandem MS with collision-induced dissociation was implemented to improve signals, LODs and to characterize the other analytical figures-of-merits (including detection of the main fragment ions, determination of optimal laser beam width and irradiance depending on the compounds). For the two metabolites of valproic acid, the ions and fragments had identical values; therefore, a mix of the two isomers had to be applied and separated with dichloromethane – methanol 50:1 before MS; one half of the plate was visualized for control by dipping into potassium permanganate reagent (7.5g KMnO4, 50g K2CO3, 0.75g NaOH in 1L water).

      Classification: 4e, 7, 8b, 11a, 18a, 22
      125 047
      Comparative study on the determination of ethyl p-methoxycinnamate in Kaempferia galanga rhizome by HPTLCS and HPLC
      K. ZHANG (Zhang Kui), W. WU (Wu Wenxia), S. TIAN (Tian Shuge)* (*College of TCM, Xinjiang Medical University, Urumqi 830011, Xinjiang, China, tianshuge@hotmail.com)

      J. Planar Chromatogr. 33, 51-57 (2020). HPTLCS (high-performance thin-layer chromatography scanning) of ethyl p-methoxycinnamate in the rhizome of Kaempferia galanga on silica gel with hexane - ethyl acetate 18:1. Quantitative determination by absorbance measurement at 309 nm. The hRF value for ethyl p-methoxycinnamate was 29. Linearity was between 2 and 6 ng/zone. Intermediate precisions were below 2.4 % (n=3). Mean recovery rate was 100.1 %. Results were compared with a validated HPLC method and the HPTLCS method was more environmetnally friendly..

      Classification: 32a
      125 043
      Comparative study of HPLC-DAD and HPTLC for the simultaneous determination of a new multitarget antidiabetic ternary mixture in combined tablets
      O. EL-SHOUBASHY*, Y BELTAGY, A. ISSA, D. EL-KAFRAWY (*Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria 21521, Egypt, dinaelkafrawy@yahoo.com)

      J. Planar Chromatogr. 33, 59-70 (2020). HPTLC of metformin (1), saxagliptin (2) and dapagliflozin (3) on silica gel with chloroform - methanol - water - acetic acid 740:260:50:1. Quantitative determination by absorbance measurement at 224 nm. The hRF values for (1) to (3) were 14, 50 and 66, respectively. Linearity was between 30 and 350 µg/mL for (1), 140 and 1500 µg/mL for (2) and 50 and 600 µg/mL for (3).  Intermediate precisions were below 2 % (n=6). LOD and LOQ were 7 and 23 µg/mL for (1), 39 and 130 µg/mL for (2) and 14 and 47 µg/mL for (3), respectively. Recovery rate was between 98.9 and 100.5 % for (1), 99.2 and 100.5 % for (2) and 99.2 and 100.7 % for (3). Comparable results were obtained when compared with a HPLC method.

      Classification: 32a
      124 014
      Quantification of bioactive lignans in sesame seeds using HPTLC densitometry: Comparative evaluation by HPLC-PDA
      E. MIKROPOULOU, E. PETRAKIS, A. ARGYROPOULOU, S. MITAKOU, Maria HALABALAKI*, L. SKALTSOUNIS (*Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece, mariahal@pharm.uoa.gr)

      Food Chem. 288, 1-7 (2019). HPTLC of sesamin (1) and sesamolin (2) in sesame seed extracts on silica gel with n-pentane - diethyl ether 3:2. Quantitative determination by absorbance measurement at 290 nm. Linearity was between 25 and 150 µg/mL for (1) and 12.5 and 75 µg/mL for (2). Intermediate precision was below 3 % (n=6). The LOD and LOQ were 1.3 and 4 µg/mL for (1) and 0.4 and 1 µg/mL for (2), respectively. Recovery rate was  between 95 and 105 % for (1) and (2). Correlation of the HPTLC and a HPLC-PDA method was notably high. 

      Classification: 7
      123 024
      Different chromatographic methods for the determination of antidiabetic drugs in the presence of drug toxic impurity
      N. ABDELWAHAB, M. ADBELRAHMAN, J. BOSHRA*, A. TAHA (*Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef, 62514 Egypt, jon.maher@nub.edu.eg)

      J. Planar Chromatogr. 32, 309-316 (2019). HPTLC of vildagliptin (1) and metformin (2) in the presence of the toxic metformin impurity melamine (3) on silica gel with methanol - chloroform - formic acid 70:30:3. Quantitative determination by absorbance measurement at 215 nm. The hRF values for (1) to (3) were 78, 18 and 46, respectivley. Linearity ranged 0.2-2.6 µg/zone for (1), 0.4-4.5 µg/zone for (2) and 0.05-1.4 µg/zone for (3). The intermediate precision was below 2 % (n=3). The LOD and LOQ were 53 and 161 ng/mL for (1), 81 and 246 ng/mL for (2) and 15 and 48 ng/mL for (3), respectively. Recovery rate was 100.9 % for (1), 101.5 % for (2) and 99.2 % for (3). The results were compared statistically to the results obtained by a reported RP-HPLC method.

      Classification: 32a
      100 002
      The Contribution of Planar Chromatography to food analysis
      Gertrud MORLOCK*, W. SCHWACK (*University of Hohenheim, Institute of Food Chemistry, Garbenstr. 28, 70599 Stuttgart, Germany; gmorlock@uni-hohenheim.de)

      J. Planar Chromatogr. 20, 399-406 (2007). General aspects of food analysis using planar chromatography as an optimum tool for national and international standards to keep analysis economical. Contents: 1. The changing situation as a challenge; 2. TLC and HPTLC applications in food analysis and rapidly growing topics; 2.1 Topics in the past twenty years; 2.2 Rapidly growing topics in the future; 3. Is HPTLC a reliable quantitative method in food analysis; 3.3 Performance key data; 3.2 Method comparison; 3.3 Separating power; 4. Obstacles and benefits of planar chromatography; 4.1 Obstacles; 4.2 Benefits; 5. Future potential of HPTLC in food analysis; 5.1 Simplified sample preparation; 5.2 Simultaneous determination of analytes with different detection principles or analytes difficult to detect in general; 5.3 Digital evaluation of plate images; 5.4 Bioactivity-based detection; 5.5 Mass-selective information on demand; 5.6 Cost-effectiveness; 6. Conclusions. Planar chromatography for simple solution of difficult problems, reduced sample preparation, selective derivatization, quantitative and sensitive determinations using appropriate instrumentation, compliance with regulated environments, e. g. cGMP and cGLP, validation fulfilling requirements for reliable analysis, reduced costs, high throughput and comparable results.

      Classification: 1b
      100 180
      Thin-Layer Chromatography of Aluminium
      P.A.M. NAJAR*, R.N. CHOUHAN, J.U. JEURKAR, S.D. DOLAS, K.V.R. RAO (*Jawaharlal Nehru Aluminium Research Development and Design Centre, Amaravati Road, Nagpur, India)

      J. Chromatogr. Sci. 45 (5), 263-268 (2007). TLC of microgram levels of iron, silicon, copper, nickel, titanium, magnesium, manganese, and zinc present in a high concentration aluminium matrix, on silica gel with aqueous sodium chloride solution. Quantification by densitometry. Comparison of the densitometric quantitative determination results of iron, silicon, nickel, and copper with the respective optical emission spectral analytical data.

      Classification: 33
      102 010
      Application of Scion Image software to the simultaneous determination of curcuminoids in turmeric (Curcuma longa)
      U. SOTANAPHUN*, P. PHATTANAWASIN, L. SRIPHONG (*Faculty of Pharmacy, Silpakorn University, Nakhon-pathom, Thailand, h8773con@ella.hu)

      Phytochem. Anal. 20, 19-23 (2009). TLC of curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3) from the rhizomes of Curcuma longa on silica gel with hexane – chloroform – methanol 10:10:1 as mobile phase. Quantitative determination by recording the chromatogram using a digital scanner and analyzing the density of the TLC spot with the Scion Image software. The hRf values of (1), (2), and (3) were 42, 25, and 18, respectively. Selectivity regarding matrix was given. Linearity was between 0.375 and 6 µg/spot for all curcuminoids. The intermediate precision of the method was satisfactory. Recovery was 101.9 % for (1), 104.8 % for (2), and 101.5 % for (3). The limits of detection and quantification were 43 and 143 ng/spot for (1), 69 and 230 ng/spot for (2), and 73 and 242 ng/spot for (3). The method was compared with an official densitometric method, and the analytical results were not significantly different.

      Classification: 4c, 30b