Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      129 060
      Detection of low levels of genotoxic compounds in food contact materials using an alternative HPTLC-SOS-Umu-C assay
      (*Institute of Nutritional Science, Justus Liebig University Giessen, and TransMIT Center of Effect-Directed Analysis, Giessen, Germany;

      ALTEX - Alternatives to animal experimentation, 38(3), 387-397 (2021). Samples were standards of food contact contaminants with genotoxicity (4-nitroquinoline-1-oxide (NQO), aflatoxin B1, hexachloroethane, nitroso-ethylurea, phenformin, PhIP) or negative controls (alosetron, mannitol), and extracts of coated tin cans (extracted with n-hexane – acetone at 25°C for 16 h or by heating at 60 °C with ethanol 95 % for 240 h). HPTLC on RP18W layer, pretreated to harden the binder by heating 1 h at 120 °C, prewashed with methanol and with ethyl acetate and dried 4 min in cold air stream after each development. Application areas were focused to their upper edges by a two-fold elution with ethyl acetate, followed by 1 min drying in cold air stream. Development with toluene – ethyl acetate 8:5, followed by 5 min drying, neutralization with citrate buffer (pH 12) and 4 min drying. Effect-directed analysis for genotoxicity (SOS response – UMU-C test, using NQO as positive control) by immersion (speed 3.5 cm/s, time 3 s) into Salmonella typhimurium suspension and, after 3 h incubation at 37 °C and 4 min drying in cold air stream, into one of two fluorogenic substrate solutions (methylumbelliferyl- vs. resorufin-galactopyranoside). After 1 h incubation at 37 °C, visualization of mutagenic compounds as (blue vs. red) fluorescent zones at FLD 366 nm, and densitometry performed with mercury lamp for fluorescence (at  366 / >400nm vs. 550 / >580 nm, respectively). Further validation experiments, including spiking extracts with NQO, were performed showing good mean reproducibility, no quenching or other matrix effects. Lowest effective concentration of NQO was 0.53 nM (20 pg/band), 176 times lower than in the corresponding microtiter plate assays.

      Classification: 4e, 5c, 8b, 16, 23d, 23e, 32d
      106 117
      Thin-layer chromatography of pyridinium aldoximes using distinct techniques for development
      H. KALÁSZ*, E. MINGSOVICS, N. RAM, K. KUCA (*Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary;

      J. Liq. Chromatogr. Relat. Technol. 33, 922-935 (2010). TLC and HPTLC of 22 different pyridinium aldoximes on silica gel with water - acetonitrile - acetic acid 8:1:1, water - acetone - acetic acid 8:1:1, and acetone - 50 mM aqueous sodium acetate 1:4 using unsaturated and saturated vapor phase as well as OPLC. Detection under UV 254 nm.

      Classification: 23d
      99 057
      Quantitative determination and stress degradation studies on a biomarker trigonelline by a validated stability-indicating HPTLC method
      S. CHOPRA*, S. K. MOTWANI, Z. IQBAL, F. J. AHMAD, R. K. KHAR (*Faculty of Pharmacy, Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India;

      J. Liq. Chromatogr. & Relat. Technol. 30, 557-574 (2007). TLC of trigonelline (3-carboxy-1-methylpyridinium hydrochloride) and degradation products on silica gel with n-propanol - methanol - water 4:1:4 in a twin-trough chamber. Quantitative determination by absorbance measurement at 269 nm.

      Classification: 23d
      106 118
      Use of TLC and densitometry to evaluate the chemical stability of nicotinic acid and its esters on silica gel
      W. PARYS, Alina PYKA* (*Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Silesia, 4 Jagiellonska Street, 41-200 Sosnowiec, Poland;

      J. Liq. Chromatogr. Relat. Technol. 33, 1038-1046 (2010). TLC of nicotinic acid and methyl, ethyl, isopropyl, butyl, hexyl, and benzyl nicotinate (heated for 1 to 7 h at 120 °C) on silica gel pre-washed with methanol using methanol - benzene (for nicotinic acid) and acetone - hexane 2:3 for nicotinic acid esters. Quantitative determination by densitometric absorbance measurement at the respective absorption maximums (263 nm for nicotinic acid, 220-222 nm for nicotinic acid esters). The hRf of nicotinic acid was 44, and of methyl, ethyl, isopropyl, butyl, hexyl, and benzyl nicotinate 48, 46, 51, 54, 56, and 44, respectively.)

      Classification: 23d
      107 079
      Simultaneous estimation of amlodipine besylate and telmisartan in their combined dosage form by spectophotometric and HPTLC methods
      A. BHADIVADRA*, Y. KOLADIYA, H. BHATT, P. MEHTA (*Dept. of Pharmaceutical Analysis, Institute of Pharmacy, Nirma University, Ahmedabad 382481, Gujarat, India)

      62nd Indian Pharmaceutical Congress Abstract No. F-389 (2010). TLC of amlodipine and telmisartan on silica gel with chloroform – methanol – toluene 10:7:3. The hRf values were 23 and 75 for amlodipine besylate and telmisartan respectively. Quantitative determination by absorbance measurement at 238 nm. The sample was also analysed by spectophotometry and the results by both methods were comparable.

      Classification: 23d
      107 093
      Simultaneous determination of amlodipine besylate and enalapril maleate by HPTLC method
      M. PATIL*, A. TAMBOLI, V. BHALERAO, R. DESHMUKH (*Sahyadri College of Pharmacy, Methewade, Tal. Sangola, Dist. Solapur, MS, India)

      62nd Indian Pharmaceutical Congress Abstract No. F-256 (2010). TLC of amlodipine besylate and enalapril maleate on silica gel with toluene – isopropanol – glacial acetic acid – methanol 50:20:6:5. The hRf values were 15 and 23 for amlodipine besylate and enalapril maleate, respectively. Quantitative determination by absorbance measurement at 223 nm.

      Classification: 23d
      107 099
      Stability indicating HPTLC method for the simultaneous determination of amlodipine besylate and telmisartan from tablet dosage form
      A. THOMAS*, S. JAGDALE, S. BHOSALE, A. DESHPANDE (*DR. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, MS, India)

      62nd Indian Pharmaceutical Congress Abstract No. F-254 (2010). TLC of amlodipine besylate and telmisartan on silica gel with ethyl acetate – methanol – 25 % ammonia – glacial acetic acid 75:15:1:2. The hRf value was 34 and 60 for amlodipine besylate and telmisartan, respectively. Quantitative determination by absorbance measurement at 226 nm. The linearity was in the range of 500-6000 ng/band for amlodipine and 1000-8000 ng/band for telmisartan. The sample was subjected to various stress conditions and all the degradation products were well resolved from the pure drugs. The method can be used for stability studies.

      Classification: 23d
      56 107
      Chromatographic study of various acridine-glycosides by TLC and HPLC methods
      J. JAVOR, I. KISS

      Budapest Chromatography Symposium June 13, 1985. Optimization of TLC separation of biologically active acridine glycosides; more than 50 solvent systems and 10 "straight" and reversed-phase layers investigated. Best results with MERCK silica gel and isobutanol - ethanol - water - NH3 55:20:20:5.

      Classification: 23d, 32a