Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

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      131 087
      Screening design and response surface methodology for the simultaneous estimation of carvedilol and ivabradine HCl by HPTLC method
      P. PRAJAPATI*, K. NAIK, P. TAILOR, S. SHAH (*Dep. of Qual. Assur., Maliba Pharm. Coll., Maliba Campus, Bardoli-Mahuva road, Tarsadi, Surat, Gujarat 394 350, India,

      J. Chrom Sci., 60 (9), 859-870 (2022). Development of an HPTLC method for the simultaneous estimation of carvedilol (CAR) and ivabradine (IVA). The combination of CAR and IVA is used for reduction of the heart rate and for achieving better exercise capacity in patients with chronic heart failure. The design approach based on the principles of analytical failure modes critical effect analysis (AFMCEA) and design of experiments (DoE) as per the upcoming ICH Q14 guideline were applied. Starting the AFMCEA by the identification of potential analytical failure modes followed by their critical effect analysis by a DoE-based screening design. Optimization of the high-risk failure modes by DoE-based response surface methodology. Framing the method operable design ranges and control strategy for optimized chromatography conditions. Validation of the HPTLC method as per ICH Q2 (R1) guideline. Application for the assay of facility design criteria (FDC) of CAR and IVA, giving the results in compliance with the labeled claim, and proven the developed method able to be used as an alternative to the published RP-HPLC method for quality control of FDC of CAR and IVA in the pharmaceutical industry.

      Classification: 32c
      131 084
      Application of the green analytical procedure index to the simultaneous analysis of co formulated tinidazole and ciprofloxacin using an environmentally friendly micellar HPTLC technology
      R. SARAYA*, Y. HASSAN, W. ELTOUKHI, B. SALMAN (*Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Port Said University, Port Said 42511, Egypt,

      J. Planar Chromatogr. 36, 21-30 (2023). HPTLC of tinidazole (1) and ciprofloxacin (2) in pure form, tablet dosage form and human plasma on silica gel with acetone - ethanol - 2 % watery sodium dodecyl sulfate 3:4:2. Quantitative determination by absorbance measurement at 310 nm. The hRF values for (1) and (2) were 22 and 42, respectively. Linearity was in the range of 25-1000 ng/zone for (1) and 80-1000 ng/zone for (2). Intermediate precisions were below 2 % (n=3). LOD and LOQ were 7 and 20 ng/zone for (1) and 25 and 75 ng/zone for (2). Average recovery was 99.9 % for (1) and 99.7 % for (2).

      Classification: 32c
      131 004
      Simultaneous determination of montelukast sodium and loratadine by eco-friendly densitometry and spectrophotometric methods
      Shimaa A. MAHMOUD*, A.M. EL-KOSASY, F.A. FOUAD
      (*Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt;

      J Chrom Sci, bmad025 (2023). Standards (separated and mixed) were montelukast sodium (MKT) and loratadine (LRT). Samples were methanolic solutions of commercial tablets, and purified blood plasma as biological fluid, from patients taking MKT or LRT as oral treatment. TLC on silica gel with ethyl acetate – ethanol 9:1. Visualization under UV 254nm. The hRF values were 80 for MKT and 71 for LRT. Densitometric absorbance measurement at 260 nm (20 mm/s scanning speed). System suitability was verified by resolution, selectivity, capacity and absence of tailing. The method was validated for linearity range (0.3–3.6 μg/zone for MKT, 0.2–4 µg/zone for LRT), for precision, for reproducibility, for robustness, and for accuracy expressed as average recovery values (100 % overall mean) at different concentrations. The TLC-densitometric method was also found statistically equivalent (Student’s t-test and F-test) to a previously described method (HPLC – spectrophotometry), but was better in terms of environmental and health impacts, using green analytical procedure index (GAPI) and analytical eco-scale (scores based on solvents/reagents, energy consumption, occupational hazard and waste generation). The TLC method was also compared to three (equally “green”) different analytical methods of spectrophotometry (without chromatography): response correlation, absorptivity-centering and LRT-MKT ratio derivatives. The TLC method was more sensitive (LOQ values were 82 ng/zone for MKT, 20 ng/zone for LRT).

      Classification: 5c, 7, 17c, 23d, 23e, 24, 32a, 32c
      130 005
      Multiobjective optimization of microemulsion – thin layer chromatography with image processing as analytical platform for determination of drugs in plasma using desirability functions
      Noura H. ABOU-TALEB*, D. T. EL-SHERBINY, N. M. EL-ENANY, H. I. EL-SUBBAGH (*Medicinal Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;

      J Chromatogr A, 1619, 460945 (2020). Samples were lamotrigin as standard, or extracted with an oil-in-water microemulsion (10 µL butyl acetate, 4 mL n-butanol, 925 mg sodium dodecyl sulphate, 8.6 mL water) either from patients’ raw plasma (for separation from blood proteins) after spiking, or from commercial tablets dissolved in methanol. TLC on silica gel with a water-in-oil microemulsion of 9 mL butyl acetate, 1 mL n-butanol, 250 mg sodium dodecyl sulphate, 250 µL water. Both optimal microemulsions were predicted using Taguchi orthogonal array and Plackett-Burman design. Evaluation in UV 254 nm, quantification from the digital picture using four image processing software programs. For lamotrigin (hRF 24), limits of quantification were 170 ng for pure drug and 10 ng for spiked plasma. Linearity (in range 20–200 ng/spot) was directly obtained for the calibration curve in spiked plasma; however, for pure drug, linearity was obtained only when using log values of the calculated densities (300–3000 ng/spot).

      Classification: 3a, 3d, 5c, 23e, 32c
      127 036
      Influence of cation transporters (OCTs and MATEs) on the renal and hepatobiliary disposition of [11C]metoclopramide in mice
      I. HERNANDEZ, S. MAIRINGER, M. SAUBERER, J. STANEK, T. FILIP, T, WANEK, G. CIARIMBOLI, N. TOURNIER, O. LANGER* (*Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria,

      Pharm. Res. 38, 127-140 (2021). HPTLC of [11C]metoclopramide in plasma, kidney, urine and liver extracts on silica gel with ethyl acetate - ethanol - 25 % ammonium hydroxide 16:4:1. Detection using a multisensitive phosphor screen. The hRF value for [11C]metoclopramide was 60. The method allowed kinetic analysis in different organs after radiotracer injection in mice.


      Classification: 32c, 34
      125 003
      A simple, rapid and sensitive high-performance thin-layer chromatographic method for the simultaneous estimation of berberine and 5-fluorouracil in rabbit plasma
      P. TAMANE*, R. PAI, V. POKHARKAR (*Department of Drug Regulatory Affairs, Bharati Vidyapeeth (Deemed to be) University, Poona College of Pharmacy, Erandwane, Pune, Maharashtra 411038, India,

      J. Planar Chromatogr. 33, 169-177 (2020). HPTLC of berberine (1) and 5-fluorouracil (2) in rabbit plasma on silica gel with toluene - methanol - ethyl acetate - formic acid 6:2:6:1. Quantitative determination by absorbance measurement at 266 nm. The hRF values for (1) and (2) were 28 and 57, respectively. Linearity was between 20 and 300 ng/zone for both (1) and (2). Intermediate precisions were below 7 % (n=3). The LOQ was 29 ng/zone for (1) and 26 ng/zone for (2), respectively. Average recovery was 86.5 % for (1) and 87.2 % for (2).

      Classification: 32c
      124 052
      Simultaneous determination of thalidomide and dexamethasone in rat plasma by validated HPLC and HPTLC with pharmacokinetic study
      N.S. ABDELWAHAB, N.W. ALI, M.M. ZAKI*, S.M.Z. SHARKAWI, M.M. ABDELKAWY (*Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmed Hegazy St., Beni-Suef, Egypt,

      J. of Chromatogr. Sci. 57 (2), 130-138 (2019). Development of a method for the simultaneous determination of thalidomide (THD) and dexamethasone (DEX) in rat plasma using paracetamol as an internal standard by HPTLC on silica gel with methylene chloride - acetone - ethyl acetate 7:4:1. Detection by absorption measurement at 235 nm. Linearity was in the range of 0.02 - 100 µg/zone for THD and 0.02 - 3 µg/zone for DEX. LOD and LOQ were 7 and 20 ng/zone both for THD and DEX. Validation by testing all parameters using quality control samples as per FDA guidelines. Successful application of the method to study the pharmacokinetic parameters of both THD and DEX after their intra-peritoneal administration.

      Classification: 32c
      124 030
      Herb–drug interaction of quercetin on the pharmacokinetics of losartan in rats: a high-performance thin-layer chromatography study
      S. JADHAO, A. THOMAS*, A. RAJE, S. NAGRIK, L. KOTHAPALLI, A. SHAIKH (*Department of Pharmaceutical Quality Assurance, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India,

      J. Planar Chromatogr. 32, 401-409 (2019). HPTLC of losartan potassium in plasma on silica gel with toluene - ethyl acetate - acetone - formic acid 8:8:2:1. Quantitative determination by absorbance measurement at 240 nm. The hRF value for losartan was 57. Linearity was between 50 and 1200 ng/mL. Intermediate precision was below 3 % (n=6). Recovery rate was between 95 and 99 %.

      Classification: 32c