J. Chromatogr. 427, 121-130 (1988). TLC of cyclophosphamide and its metabolites on silica with chloroform - ethanol - acetic acid 100:20:1. Detection by spraying with 5% 4- (4-nitrobenzyl)pyridine in acetone-0. 2 M acetate buffer pH 4. 6 8:2 and heating at 130-150°C for 5-15 min. and dipping in 3% methanolic potassium hydroxide. Photography of the chromatogram within 10 seconds. Quantification by densitometry. Detection limit, 0. 5-1 µg/L. The calibration curves were found linear over a range of 1-250 µg/mL.

Pharmazie 63, 102-106 (2008). TLC of benzyl 2-acetamido-6-O-acetyl-3-O-[(R)-1-carboxyethyl]-2-deoxy-alpha-D-glucopyranoside 1’,4-lactone, 2-acetamido-6-O-acetyl-3-O-[(R)-1-carboxyethyl]-2-deoxy-alpha-D-glucopyranoside 1’,4-lactone, and 2-acetamido-6-O-acetyl-3-O-[(R)-1-carboxyethyl]-2-deoxy-alpha-D-glucopyranoside-1-alpha-(diphenyl phosphate) 1’,4-lactone on silica gel with ethyl acetate - acetone 2:1. TLC of triethylammonium muramyl phosphate on silica gel with isopropanol - water - 25 % ammonia 6:1:3. Evaluation under UV light and by heating the plate at 250 °C.

Proc. 6th Int. Symp. Instrum. Planar Chromatogr., (Interlaken 1991), Inst. Chromatogr., Bad Dürkheim, FRG, 401-408 (1991). Preliminary results are described for the combination of off-line TLC-FAB-MS for polar, ionisable compounds and their conjugated metabolites. HPTLC of benzoic acid, hippuric acid, phenolphthalein and its gucuronide, nitrophenol and its glucuronide and paracetamol and its sulfate on silica with chloroform - ethanol 3:2. Separated substances were removed and determinated by FAB-MS and MS-MS.

Ind. J. Pharm. Sci. 70(3), 398 - 400 (2008). HPTLC of ibuprofen and pseudoephedrine HCl on silica gel with tert-butanol - ethyl acetate - acetic acid - water 7:4:2:2. Quantitative determination by absorbance measurement at 254 nm. The hRf value of pseudoephedrine was 68 and of ibuprofen 91. The method was linear in the concentration range of 45.6 - 75.6 µg/mL for ibuprofen and 6.8 - 11.3 µg/mL for pseudoephedrine. The recovery was between 100.7 and 101.0 % for both compounds. The method was suitable for routine quality control.

J. Chromatogr. 580, 125-134 (1992). Discussion of the analysis of 31 drugs and drug metabolites in human hair by TLC, HPLC, GC, and GC-MS.

CBS 101, 12-13 (2008). During a drug substance stability study a mass imbalance was discovered in light degraded samples. HPTLC on silica gel first with ethyl acetate - heptane, then, after drying, with tetrahydrofuran in a horizontal developing chamber. Detection under UV 254 nm and by densitometry at 240 nm. During another project differences in color between batches of a drug substance were observed. HPTLC on amino phase with methanol in a horizontal developing chamber. Detection under white light and under UV 366/>400 nm.

Chinese J. Pharm. (Zhongguo Yaoxue Zazhi) 28, 550-552 (1993). TLC on silica with hexane - chloroform - methanol 5:3:1. Quantification by densitometry at 254, 249 and 214 nm for diazepam, methaqualone and estazolam, respectively.

J. Liq. Chromatogr. Relat. Technol. 30, 2369-2383 (2007). TLC of 2-arylpropionic acids, namely ibuprofen and naproxen, on silica gel and silica gel impregnated with a 0.03 mol/L solution of L-arginine in methanol by dipping for 2 s, with ethanol and ethanol containing several drops of acetic acid. Quantitative determination by absorbance measurement at 254 nm. It was demonstrated that the crystalline chirality of the silica gel adsorbent is most probably responsible for the horizontal enantioseparation, whereas the molecular chirality of L-arginine deposited on the silica gel layer is responsible for the vertical enantioseparation.