Pharmazie 60, 110-114 (2005). TLC of two glyceride derivatives of mefenamic acid (“3a and 3b“) on silica gel with hexane - ethyl acetate 5:1. Detection by exposure to iodine vapors.

extract and its traditional formulation from rat plasma; application to pharmacokinetics. J. Planar Chromatogr. 27, 23-28 (2014). HPTLC of marmelosin in plasma on silica gel with toluene - ethyl acetate - glacial acetic acid 70:30:1. Quantitative determination by absorbance measurement at 310 nm. The hRF value for marmelosin was 57. Linearity was between 1 and 150 µg/mL. The intermediate/interday/intra-day precisions were below 6 % (n=6). The LOD and LOQ for marmelosin was 150 ng/mL and 1000 ng/mL, respectively. Recovery was in the range of 90.9-106.1 %.

(Screening of halazepam, a new antianxiety agent.) Fresenius Z. Anal. Chem. 321, 359-362 (1985). Use of TLC as a sensitive screening method for 1,4-benzodiazepine derivative (halazepam). After hydrolysis TLC of 2 (2,2,2-trifluoroethyl) amino-5-chloro-benzophenone on silica with toluene. After photolytic desalkylation and diazotation spraying with Bratton-Marshall reagent.

J. Chromatogr. 442, 459-463 (1988). One- and two-dimensional TLC of thyrostatics on silica with chloroform - acetone 7:3 for the first direction and ethyl acetate for the second. Detection by spraying with palladium (II)-calcein reagent and inspection under UV 365 nm. Identification by comparison of Rf values in different solvent systems. Detection limit, 200 ppb for 6-methyl-2-thiouracil.

Arzneim.-Forsch. 39, 579-586 (1989). TLC separation of tiropramide and basic, acidic and aminoacidic, neutral metabolites on silica with 5 different solvent mixtures. Detection under UV 254 nm; quantification by scintillometry after removal from the plate.

J. Planar Chromatogr. 8, 92-97 (1995). TLC of deramciclane and metabolites on silica with butanol - acetic acid - water, ethyl acetate - triethylamine, and ethyl acetate - ethanol - triethylamine in different ratios. Digital autoradiographic evaluation was used for obtaining rapid information; in situ semiquantitative analysis of compounds separated was performed.

J. Planar Chromatogr. 11, 25-29 (1998). Description of the powerful off-line combination of rapid, high-resolution overpressured-layer chromatography (OPLC) with the high sensitivity and rapidity of digital autoradiography (DAR), by which qualitative and quantitative analysis of radiolabeled metabolites in biological samples can be performed relatively quickly. OPLC/HPTLC of deramciclane (1R,2S,4R-(-)-N,N-dimethyl-2-[(1,7,7-trimethyl-2- phenylbicyclo[2,2,1]hept-2-yl)oxy]-ethaneamine 2-(E)-butanedioate) on silica gel with n-butanol - acetic acid - water 4:1:1, ethyl acetate - ethanol - triethylamine 25:25:2, acetonitrile - n-butanol - acetic acid - water 25:17:4:4 or 44:30:7:19. For comparison to the radioactivity signal, UV and fluorescence signals were evaluated at 254 and 366 nm.

J. Planar Chromatogr. 19, 27-31 (2006). Use of TLC to investigate possible chemical interactions of vitamins A and D with frequently used therapeutics (estrogens and progestins, corticosteroids, HMG CoA reductase inhibitors, vitamins, and non-steroidal anti-inflammatory drugs). Concentrations of vitamins and drugs applied to the plates were adjusted to mimic the doses usually prescribed in therapy. TLC on silica gel with cyclohexane - ether 1:1, 17:3, and ethyl acetate. The strength of interaction was measured as a surface below or above a distorted part of the sample band, visible under UV light at 254 nm or after exposing the plates to iodine vapor.