Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

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      130 144
      Combining multivariate image analysis with high-performance thin-layer chromatography for development of a reliable tool for saffron authentication and adulteration detection
      A. AMIRVARESI, M. RASHIDI, M. KAMYAR, M. AMIRAHMADI, B. DARAEI, H. PARASTAR* (*Department of Chemistry, Sharif University of Technology, Tehran, Iran; h.parastar@sharif.edu)

      J Chromatogr A, 1628, 461461 (2020). Samples were hydro-methanolic extracts of 100 genuine saffron samples (Crocus sativus stigmata, Iridaceae) from South Khorasan (SK) and Razavi Khorasan (RK) provinces (Iran), pure or mixed in several proportions with common vegetal adulterants: C. sativus style, Calendula officinalis petals (Asteraceae, Asteroideae), Carthamus tinctorius petals (Asteraceae, Carduoideae), Rubia tinctorum rhizomes (Rubiaceae). Commercial saffron samples (containing artificial adulterants) were also tested. TLC on silica gel with ethyl acetate – methanol – water – acetic acid 66:23:11:1. Evaluation at 254 nm, 366 nm, and 440 nm. Crocin (carotenoid, hRF 38) was used for optimization of extraction (parameters being first calculated by chemometry), using multilinear regression and ANOVA. Image data (pixel intensities and colors of each sample under the three selected wavelengths) were unfolded into a data matrix and transformed into a vector, used for multivariate image analysis of the chromatogram fingerprints. This allowed: A) separation of genuine samples by principal component analysis (PCA) into 2 clusters according to origin (cold climate in Northern half of RK vs. warm climate in SK and Southern part of RK) with 92 % prediction accuracy; B) separation of samples according to purity / vegetal adulterant groups by partial least squares – discriminant analysis (PLS-DA) with 98 % accuracy (if 10 µL extract applied); C) separation with 100 % prediction accuracy by PCA between genuine, mixed, and commercial samples.

      Classification: 4c, 4e, 8b, 14, 32e
      128 051
      Multivariate regression and artificial neural network to predict phenolic content in Schinus terebinthifolius stem bark through TLC images
      R. THAIS DE MORAES, M. ARAUJO, P. ANDRADE, M. ASSUNCAO, W. PINHEIRO, L. LIRA (*Laboratory, Department of Pharmaceutical Sciences – UFPE, Av. Arthur de Sa, Varzea, Recife PE 50740-521, Brazil, luiz.albertosoares@ufpe.br)

      J. Liq. Chromatogr. Relat. Technol. https://doi.org/10.1080/10826076.2021.1932521 (2021). HPTLC of gallic acid in the stem bark of Schinus terebinthifolius on silica gel with toluene - ethyl acetate - formic acid - methanol 15:15:4:1. The plates were scanned at 254 nm and 366 nm. The hRF value for gallic acid was 43. Image features were acquired using a combination of two approaches: Haralick texture features and Zernike moments. The GNU OctaveVR software was used to set the architectures of the Artificial Neural Network. The mathematical data provided by the image analysis was correlated with the gallic acid content determined by HPLC. The method allowed the prediction of phenolic content through TLC plate images.

      Classification: 4c, 7
      104 013
      A comparative study on several algorithms for denoising of thin-layer densitograms
      L. KOMSTA (Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland)

      Anal. Chim. Acta 641 (1-2), 52-58 (2009). Comparison of classical filtering techniques (Savitzky–Golay, Adaptive Degree Polynomial Filter, Fourier denoising, Butterworth and Chebyshev IIR filters) and wavelet shrinkage (31 mother wavelets, 3 thresholding techniques and 11 decomposition levels) with the original noisy signal and a reference signal which was denoised experimentally by averaging 64 measurements. The best similarity to the reference signal was obtained with filters, however the signal was slightly oversmoothed. The wavelet shrinkage method gave less denoised signals. There was a significant influence of the thresholding technique and decomposition level, and best conditions were at level 2 or 3 and soft thresholding), whereas changing of the mother wavelet almost did not change the result. The presented results can be used as general recommendations for denoising densitometric fingerprints before applying further chemometric algorithms. The best choices were: Savitzky–Golay filter of appropriate window width (optimized against autocorrelation) or wavelet shrinkage with Haar wavelet, soft thresholding and high decomposition level.

      Classification: 4c
      65 049
      Quantitative thin layer chromatography
      M. PROSEK, M. PUKL, (Kemijski Institut „BORIS KIDRIC“, Hajdrihova 19, 61115 Ljubljana, Yugoslavia)

      8. Integration problems in QTLC. J. Planar Chromatogr. 2, 128-132 (1989). Some integration problems in quantitative TLC are illustrated. A prepared program simulates chromatograms with different position, concentrations, and shapes of chromatographic peaks. The results of integration are presented and discussed. In TLC it is necessary to find the correct peak start. Evaluation of a small peak after a big one can be done more precisely than the evaluation of a small one in front of a large one.

      Classification: 4c
      115 006
      Comparative lipophilicity of morphine derivatives
      H. KALASZ*, R. DOLEZAL, Kornelia TEKES, K. MAGYAR, T. CSERMELY, S. HOSZTAFI (*Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvarad ter 4, Hungary, drkalasz@gmail.com)

      J. Planar Chromatogr. 28, 126-132 (2015). TLC of 17 morphine derivatives on RP phase with 3 different mobile phases, (1) methanol - 0.02 M ammonium hydroxide, (2) methanol - 0.7 M ammonium hydroxide, and (3) methanol - 0.02 M acetic acid. In each case, the individual mobile phases contained 30-90 % (v/v; in 10 % increments) of methanol as an organic modifier. Detection by absorbance measurement at 254 nm. RP-TLC can be used for the characterization of the lipophilicity of semisynthetic derivatives of morphine.

      Classification: 2c, 4c, 22
      66 042
      Identification power of thin-layer chromatographic color reactions and integration of color codes in a data base for computerized identification in systematic toxicological analysis
      R.A. De ZEEUW*, D.T. WITTE, J.-P. FRANKE, (*Dep. Anal. Chem. & Toxicol., Univ. Cent. for Pharm., A. Deusinglaan 2, NL-9713 AW Groningen, The Netherlands)

      J. Chromatogr. 500, 661-671 (1990). Development of a system making color reactions on TLC plates amenable to computer handling. Identification of unknown substances using corrected Rf values and color reactions by means of computerized retrieval from large data base, based on a series of four color reactions carried out in sequence on the same spot and by numeric encoding of the observed color with a color reference chart. Comparison of the identification power with that of GC. GC retention indices and UV absorption maxima can also be introduced in the identification program. Use of a single TLC system with color reactions provides about the same identification power as a single GC system and can be increased by using two or more different TLC systems in parallel.

      Keywords:
      Classification: 4c
      115 007
      Chemometric comparison of thin-layer chromatography, gradient high-performance liquid chromatography, and computational methods for lipophilicity assessment of model compounds
      L. KOMSTA*, R. PIETRAS, Ewelina BARTUZI, R. SKIBINSKI, Anna GUMIENICZEK (*Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland, lukasz.komsta@umlub.pl)

      J. Planar Chromatogr. 28, 115-118 (2015). TLC of 35 compounds on RP-18 and cyano phase with six modifiers (acetonitrile, acetone, dioxane, propan-2-ol, methanol, and tetrahydrofurane). The extrapolated Rm data were recomputed and compared to HPLC results with 2 modifiers. HPLC (in gradient mode) and TLC perform in comparable manner in the lipophilicity assessment of the investigated model compounds. With its simplicity, it is a strong argument to use TLC in lipophilicity studies.

      Classification: 2c, 4c
      67 031
      Image processing - new perspective in QTLC
      M. PROSEK, I. DRUSANY, (Boris Kidric Inst. of Chem., Hajdrihova 19, Ljubljana, Yugoslavia)

      Proc. 6th Int. Symp. Instrum. Planar Chromatogr., (Interlaken 1991), Inst. Chromatogr., Bad Dürkheim, FRG, 273-282 (1991). Densitometry by slit scanning mode was compared with processing mode using a video camera. A sugar TLC-chromatogram was used as example; chromatographic data not stated.

      Keywords: densitometry
      Classification: 3f, 4c