Proc. Intern. Symp. on Planar Separations Plan. Chrom. 399-405 (2003). TLC of 4-phenyl-1-butanol, 5-phenyl-1-pentanol, 3-phenylpropionic acid and 3-phenylbutyric acid on cellulose with i.e. decalin in the classical chamber of Stahl-type and the sandwich-type. Densitometry at 260 nm in reflectance mode. It was clearly demonstrated that, under the conditions used, the sandwich-type chamber can by no means be considered as superior to the Stahl-type chamber.

TrAC 25, 8 (2006). In the individual monographs of drug substances or finished products, only semi-quantitative TLC purity tests are mentioned and the number of TLC applications is steadily decreasing, being replaced by HPLC methods that are considered more appropriate. However, to comply with the latest and current pharmaceutical regulations, TLC manufacturers do not stop developing new equipment and accessories related to sample application, developing chambers, derivatization, documentation, and quantitative evaluation. Numerous examples of TLC/HPTLC applications in analytical research and quality control are mentioned to show the validity of this technique in the description of organic related impurities in drug substances and final products. Finally, authors ask analysts to present excellent, fully-validated and documented GMP/GLP-compliant TLC purity-test procedures to convince experts from pharmacopoeial committees and regulatory bodies of the importance of this analytical tool.

J. Liquid Chrommatogr. 9, 1849-1860 (1986). TLC measurement of excess adsorption isotherms for different binary liquid mixtures on silica gel. Interpretation of these isotherms by means of the Langmuir-Freundlich equation, which involves the adsorbent heterogeneity and molecular size difference of the components

J. Chromatogr. 591, 1-18 (1992). A review with 32 references on several theories appropriate to the modeling of zone overlap in two-dimensional TLC and other separation techniques.

J. Planar Chromatogr. 10, 97 -107 (1997). Theoretical and experimental comparison of the PRISMA and Snyder-Soczewinski models and the thermodynamic method of optimizing mixture separation in planar chromatography. Comparison of chromatographic separations has been performed by means of TLC of 18 quinoline derivatives on silica with 12 organic solvents.

Anal. Chim. Acta 593 (2), 224-237 (2007). Presentation of a novel atomic-contribution system for predicting RM values by TLC on silica gel with 13 screening systems where the large experimental datasets (198-761 RM values) are available. RM values could be predicted with less than 0.5 % error in the majority of solutes (besides several outliers), which corresponds to an hRf value difference of 28 in the worst case. Validation of the system by dividing the data into training and validation datasets, proving its accuracy. The main reason for outliers were large conjugated heterocycles, quarternary ammonium cations, large amount of polar atoms or very simple but unique molecules. The method invloves easy manual calculation and no need for a software. It was applied to predict retention of new compounds in existing chromatographic screening systems.

determination of log P of (E)-3-benzylidene-2,3-dihydro-1-benzopyran-4-ones by RP-TLC. Effect on log P of incorporation of oxygen atom into carbocyclic chalcone analogues. J. Planar Chromatogr. 26, 284-288 (2013). Log P-TLC of (E)-3-benzylidene-2,3-dihydro-1-benzopyran-4-ones on silica gel with methanol - water 3:2. Detection under UV light at 254 nm. The effect of positions (ortho, meta, and para) of the aromatic substituents in the compounds was evaluated.

International Journal of Molecular Sciences 3(7), 755-763 (2002). The introduction reviews in details the history of the Rm value, which means log(1/Rf – 1), and of its use to calculate the partition coefficient. For 10 aminoalkanethiosulfuric acids, 8 mercaptoalkanamines and 3 aminoalkyl disulfides, Rf and Rm values were determined by reverse phase TLC on silica gel (previously dessicated and impregnated with octanol – chloroform 1:19), with binary mixtures of methanol and 0.2 M ammonium acetate buffer pH 6.0 in different proportions. Detection by exposure to iodine vapor. Rm values were extrapolated to 100 % water, which was compared to the log P values obtained with the shake-flask method and with theoretical calculations.