Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
  • Keyword register: select an initial character and browse associated keywords
  • Search by CBS edition: Select a CBS edition and find all related publications

Registered users can create a tailor made PDF of selected articles throughout CCBS search – simply use the cart icon on the right hand of each abstract to create your individual selection of abstracts. You can export your saved items to PDF by clicking the download icon.

      130 035
      Solid phase extraction and simultaneous chromatographic quantification of some non-steroidal anti-inflammatory drug residues: an application in pharmaceutical industrial wastewater effluent
      M. KORASHY*, S. GAWAD, N. HASSAN, M. ABDELKAWY (*Quality Department, Pharmaoverseas Company, 2Pharmaceutical Chemistry Department, College of Pharmacy, Prince Sattam Bin Abdul-Aziz University, Kingdom of Saudi Arabia, mohamed_korashy2007@yahoo.com)

      Braz. J. Pharm. Sci. 58, e18691 (2022). HPTLC of paracetamol (1), diclofenac sodium (2), ibuprofen (3), and indomethacin (4) in wastewater effluents on silica gel with n-hexane - ethyl acetate - acetic acid 12:7:1. Quantitative determination by absorbance measurement at 254 nm. The hRF values for (1) to (4) were 18, 56, 69 and 44, respectively. Linearity was between 0.1 and 0.9 µg/zone for (1) to (4). Inter-day and intra-day precisions were below 1 % (n=3). Mean recovery was 99.7 % for (1), 99.8 % for (2), 99.7 % for (3) and 99.2 % for (4). 

      Classification: 37c
      130 073
      Global distribution and potential risks of artificial sweeteners (ASs) with widespread contaminant in the environment: The latest advancements and future development
      X. WANG (Wang Xinglei), X. LIANG (LIang Xujun), X. GUO (Guo Xuetao)* (*College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, China, guoxuetao2005@nwafu.edu.cn)

      Trends Anal. Chem. 159, 116915 (2023). Review of analytical methodologies, distribution, ecotoxicity and removal of artificial sweeteners to determine the ecological and health risks that these substances may pose based on available data. The paper described analytical techniques, including HPTLC for the determination of artificial sweeteners in water samples.

      Classification: 37c
      130 074
      Recent advances in sampling and sample preparation for effect-directed environmental analysis
      S. HUANG (Huang Shuyao), M. FAN (Fan Mengge), N. WAWRYK, J. QIU (Qiu Junlang)*, X. YANG (Yang Xin), F. ZHU (Zhu Fang), G. OUYANG, X. LI (Li Xingfang) (*School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China, ciujlang@mail.sysu.edu.cn)

      Trends Anal. Chem. 154, 116654 (2022). Review of recent advances of sampling and sample preparation in effect-directed environmental analysis with a special focus on innovative approaches. The paper summarized sampling, enrichment and fractionation techniques for effect-directed analysis of water samples, including HPTLC methods for the analysis of potential toxicity contributors.

      Classification: 37c
      130 004
      Identification of acetylcholinesterase inhibitors in water by combining two-dimensional thin-layer chromatography and high-resolution mass spectrometry
      Lena STÜTZ*, W. SCHULZ, R. WINZENBACHER (*Laboratory for Operation Control and Research, Zweckverband Landeswasserversorgung, Langenau, Germany; stuetz.l@lw-online.de)

      J Chromatogr A, 1624, 461239 (2020). Samples were chemical standards of acetylcholinesterase (AChE) inhibitors (azamethiphos, caffeine, donepezil, galanthamine, methiocarb-sulfoxide, paraoxon-ethyl) and of neurotoxic compounds, as well as drinking or contaminated water samples enriched through solid phase extraction. HPTLC on spherical silica gel (pre-washed twice by 20 min immersion in isopropanol, heated 20 min at 120 °C before and after pre-washing with acetonitrile). First separation (preparative TLC) with automated multiple development (16 steps). Effect-directed analysis for AChE inhibitors by immersion (speed 5 cm/s, time 1 s) into enzyme solution, incubation 5 min at 37 °C and immersion into substrate solution (indoxyl acetate 2 % in methanol); visualization under UV 366 nm. Active zones from untreated layers were eluted through the oval head of a TLC-MS interface to a second plate for a second separation with a panel of other mobile phases. Bands of interest were eluted from the second layer with water through the oval elution head of the TLC-MS interface pump, into a RP18 liquid chromatography guard column, followed by a quadrupole time-of-flight mass spectrometer. Full scan mass spectra (m/z 100–1200) were recorded in negative and positive modes using electrospray ionization (and collision-induced dissociation for MS2). Among the water contaminants, lumichrome (riboflavin photolysis product), paraxanthine and linear alkylbenzene sulfonates were identified as AChE inhibitors.

      Classification: 3d, 4d, 4e, 22, 29b, 35d, 37c
      130 007
      Planar chromatography-bioassays for the parallel and sensitive detection of androgenicity, anti-androgenicity and cytotoxicity
      C. RIEGRAF, A.M. BELL, M. OHLIG, G. REIFFERSCHEID, S. BUCHINGER* (*Federal Institute of Hydrology, Koblenz, Germany; buchinger@bafg.de)

      J Chromatogr A, 1684, 463582 (2022). Samples were concentrated filtrates of leachates of waste deposition sites, as well as testosterone, flutamide, bisphenol A (BPA) and nitroquinoline oxide (NQO) as standards. Automated Multiple Development on HPTLC silica gel (prewashed with methanol and dried 30 min at 110 °C) with 1) methanol up to 20 mm; 2A) chloroform – ethyl acetate –petroleum ether 11:4:5 or 2B) ethyl acetate – n-hexane 1:1 for flutamide and testosterone, up to 90 mm. Effect-directed analysis was performed by automated spraying 3 mL suspension of BJ1991 yeast (transfected Saccharomyces cerevisiae strain, pure for androgenic activity, with 50 ng/mL testosterone for anti-androgenic assay), followed by 20 h incubation at 30 °C in a closed chamber (90 % relative humidity), by 5 min drying under cold air stream, by spraying 2.5 mL MUG solution (4-methylumbelliferyl-galactopyranoside) and by 15 min incubation at 37 °C in an open chamber. Agonistic and antagonistic activities were detected qualitatively under UV 366 nm (light or dark blue bands, respectively, on blue background) and quantitatively documented using automated scanning at excitation wavelength 320 nm (deuterium lamp), with cut-off filter at 400 nm. Dose-response curves for model compounds were established by regression analysis. Anti-androgenic effective doses at 10 % were 28 ng/zone for flutamide and 20 ng/zone for BPA, without toxicity for the yeast. To exclude cytotoxicity where anti-androgenic activity was observed, the HPTLC layers (either without or after the spraying with MUG) were sprayed with 3 mL resazurin solution (0.01 % in water) and incubated 30 min at 30 °C and 90 % humidity. Cytotoxicity bands appeared as pink zones of resorufin on a colorless background (dihydroresorufin) under white light. Densitometric evaluation in absorption mode at 575 nm (under deuterium and halogen-tungsten lamps, no filter applied). NQO was cytotoxic at its lowest tested dose (1 ng/zone).

      Classification: 4b, 4e, 32d, 37c, 37d
      124 063
      Determination of anthelmintic pharmaceuticals in wastewater by solid-phase extraction and thin-layer chromatography
      Dragana PAVLOVIC*, T. KRALIKEVIC, R. PAVIC, J. MRDA (*Department of Analytical Chemistry; and T. Gazivoda Kraljevic, Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, 10000 Zagreb, Croatia, dmutavdz@fkit.hr)

      J. Planar Chromatogr. 32, 421-429 (2019). HPTLC of levamisole (1), pyrantel pamoate (2), albendazole (3), and febantel (4) on silica gel with dichloromethane - methanol - formic acid 18:1:1. Quantitative determination by absorbance measurement at 254 nm. The hRF values for (1) to (4) were 10, 15, 47 and 79, respectively. Linearity was between 600 and 1500 µg/L for (1), 400 and 1000 µg/L for (2), 200 and 1000 µg/L for (3) and (4). The obtained RSD values were in the range from 7.0 % to 8.8 % for intra-day precision and from 8.1 % to 13.1 % for inter-day precision (n=3). The LOD and LOQ were 300 and 600 µg/L for (1), 200 and 400 µg/L for (2) and 100 and 200 µg/L for (3) and (4), respectively. Recovery rate was above 95 % for (1) to (4).

      Classification: 37c
      123 029
      Identification of genotoxic transformation products by effect-directed analysis with High-Performance Thin-Layer Chromatography and non-target screening
      Lena STÜTZ*, Patricia LEITNER, W. SCHULZ, R. WINZENBACHER (*Laboratory for Operation Control and Research, Zweckverband Landeswasserversorgung, Am Spitzigen Berg 1, 89129 Langenau, Germany, Stuetz.L@lw-online.de)

      J. Planar Chromatogr. 32, 173-182 (2019). HPTLC of chlorinated metformin samples with genotoxic effect obtained by umu assay (Salmonella typhimurium TA1535/pSK1002 Assay) on silica gel in a gradient development with methanol - formic acid 2000:1, dichloromethane and n-hexane. A TLC-MS interface was used for further analysis by LC-high-resolution mass spectrometry. 

      Classification: 32a, 37c
      111 158
      Drinking water treatment - Identification of reaction by-products of 4- and 5-methyl-1H-benzotriazole formed during ozonation
      W.H. WEBER*, W. SCHULZ, A. MUELLER, S.C. WEISS (*Zweckverband Landeswasserversorgung, Betriebs- und Forschungslaboratorium, Am Spitzigen Berg 1, 89129 Langenau, Germany, weber.w@lw-online.de)

      CBS 109, 13-15 (2012). HPTLC-AMD of tolyltriazoles and by-products after ozone treatment of water samples, on LiChrospher silica gel (pre-washed with 2-propanol and dried at 120 °C for 30 min) by automated multiple development (AMD) using a 22-step gradient from methanol - formic acid 200:1 over dichloromethane to n-hexane. Detection under UV 254 nm and by spraying with 2,4-dinitrophenylhydrazine reagent, evaluation under white light. Densitometric measurement at 190, 200, 220, 240, 260, 280, and 300 nm before derivatization and at 380, 400, and 420 nm after derivatization. Coupling of HPTLC with HPLC-QTOF/MS using the TLC-MS Interface offline with water - acetonitrile 1:1 with 5 mmol ammonium acetate as extraction solvent and a flow rate of 0.2 mL/min.

      Classification: 37c