J. Pharm. Biomed. Anal. 43 (2), 722-726 (2007). HPTLC of imatinib mesylate both as a bulk drug and in formulations on silica gel aluminium plates with chloroform - methanol 3:2. Quantitative determination by absorbance measurement at 276 nm. Linearity was between 100 and 1000 ng per spot. The limit of detection and quantitation was 10 and 30 ng, respectively. The method is repeatable, selective and accurate and can be used for stability control.

Chinese J. Trad. Pat. Med. (Zhongchengyao) 27 (2), 225-227 (2004). TLC on silica gel with 1) petroleum ether (30 - 60 ºC) - ethyl acetate 9:1; 2) benzene - glacial acetic acid 4:1. Detection 1) by spraying with 1 % vanillin solution and heating at 105 ºC for 10 min; 2) under UV 365 nm. Identification by fingerprint technique. Quantification of ferulic acid by densitometry at 325 nm. Validation of the method by investigation of linearity (0.16 µg - 1.6 µg, r = 0.9992); precision (RSD = 1.8 %, n= 5 within plate and RSD = 2.3 % plate to plate); reproducibility of five time assay towards the same sample (RSD = 0.5 %); and standard addition recovery (97.17 %, RSD = 0.9 %, n = 5). The results for three real life samples are given.

J. Chromatogr. B 846 (1-2), 334-340 (2007). Salting-out TLC of sulphonamides on silica gel with aqueous solutions of salts (sulphates, chlorides, nitrates, phosphates, acetates, and thiocyanates) showed that the applied salts have different effects on the retention of sulphonamides according to Hofmeister's classification (e.g. kosmotropes, chaotropes and neutral). Parameters of the linear regression analysis were compared with QSAR data of dependences between the RM values and salt concentration. Chromatographic data obtained by salting-out TLC showed not only the physico-chemical properties of the examined compounds but also information about their activity. The method was suitable for prediction and classification of sulphonamide drugs by localization of other structurally similar compounds with antagonistic activity towards sulphonamides.

Chinese J. Trad. Pat. Med. (Zhongchengyao) 26 (9), App. 3-5 (2004). TLC on silica gel with 1) n-hexane - ethyl acetate 9:1; 2) chloroform - methanol 5:2; 3) n-hexane - ethyl acetate 3:1. Detection 1) under UV 365 nm; 2) by spraying with 10 % H2SO4 in ethanol and heating at 110 ºC; 3) by spraying with 5 % FeCl3 in ethanol. Identification by fingerprint technique. Quantification of icariine by HPLC.

Chromatographia 70 (1-2), 305-308 (2009). Description of color channel selection, three-dimensional visualization, and acquisition time of computerized image analysis for one-dimensional planar separation, known as computerized image analysis or video densitometry. This is an efficient, low-cost technique for quantitative and qualitative analysis of planar separations, e.g. planar chromatography and gel electrophoresis. The image of the TLC plate is captured in black and white, then the proper color channel of the image is selected in order to enhance the signal-to-noise ratio. To facilitate image evaluation a three-dimensional visualization of the planar image was applied by use of OpenGL technology. It was found that the sensitivity is increased by use of longer acquisition times whereas linearity of quantitative analysis is reduced.

Acta Chrom. 16, 173-180 (2006). TLC of 14 performance-enhancing drugs (amphetamine, bemegride, caffeine, chlorphentermine, ephedrine, ethylamphetamine, isoproterenol, methadone, methyllendioxyamphetamine, pentazocine, pethidine, pemoline, strychnine and salbutamol) on bismuth silicate gel (prepared from 75 mL bismuth nitrate gel with 14 g silica gel powder) with thickness of 300 µm. 21 organic, aqueous and organic-aqueous mobile phases were investigated. Detection with iodine vapours.

Acta Chromatographica 21 (1), 83-93 (2009). HPTLC of quetiapine fumarate on silica gel with toluene - methanol 4:1. The hRf value of quetiapine fumarate was 37. Quantitative determination by absorbance measurement at 254 nm. There was no chromatographic interference from tablet excipients. The drug is susceptible to treatment with acid and alkaline hydrolysis, oxidation, and photodegradation. The method was able to separate the degradation products from the pure drug, it can be used for stability tests.

Leg. Med. 8, 184-187 (2006). HPTLC on silica gel of cocaine urine samples submitted to solid phase extraction prior to derivatization (methylation) with diazomethane. For methylation samples were mixed with 100 µL of a solution freshly prepared by distillation of 2.14 g N-methyl-N-nitroso-p-toluenesulfonamide with 10 mL potassium hydroxide 96 % in ethanol and 30 mL ethyl ether, and kept at room temperature for 1 min to convert benzoylecgonine to cocaine. Development over 7 cm in a saturated chamber with ethyl acetate – cyclo hexane – ammonia 250:100:1. Detection by spraying with Dragendorff reagent (10 mL of 40 % m/v potassium iodide in water; 10 mL of 1 N solution of bismuth nitrate in glacial acetic acid; 80 mL of 10 % v/v sulfuric acid water solution; 2 g of resublimed iodine). The technique is capable to discriminate cocaine from interfering substances such as nicotine, caffeine and even cocaethylene in urine samples. The limit of detection was 100 ng of cocaine.