Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

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      96 148
      Determination of rosuvastatin calcium in its bulk drug and pharmaceutical preparations by high-performance thin-layer chromatography
      R. T. Sane, S. S. Kamat, S. N. Menon, S. R. Inamdar*, M. R. Mote (*TDM Laboratories, Plot No. 194, Scheme No. 6, Road No. 15, Sion (E), Koliwada, Mumbai 400 022, India)

      J. Planar Chromatogr. 18, 194-198 (2005). HPTLC of rosuvastatin calcium (with aceclofenac as internal standard) on silica gel with toluene - methanol - ethyl acetate - formic acid 60:10:30:1. Quantitative determination by absorbance measurement at 265 nm. A good determination coefficient (r2 = 0.9999) was obtained for the linearity in the range of 1.0 to 15.0 µg of sample. For formulation and bulk drug the mean percentage assay was 100.09 +/- 0.20 and 100.07 +/- 0.48, respectively. The accuracy of the method was found to be 100.62 % and precision was found to vary from 0.01 to 0.77 %.

      Classification: 32a
      97 090
      Effect of the aqueous component of the mobile phase on RP-TLC retention and its implication on the determination of lipophilicity for a series of structurally diverse drugs
      C. Giaginis, D. Dellis, Anna Tsantili-Kakoulidou* (*Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, Greece)

      J. Planar Chromatogr. 19, 151-156 (2006). Investigation of the reversed-phase TLC retention behavior of a series of structurally diverse drugs, mostly basic compounds, with different aqueous mobile phase components. Phosphate buffer, phosphate-buffered saline, and morpholinepropanesulfonic acid, with or without the addition of n-decylamine, at pH 7.4, and phosphate buffer at pH 11.0 were used with different portions of methanol as mobil phase. TLC of amitriptyline, chlorpromazine, diltiazem, fluoxetine, nifedipine, nimesulide, norfluoxetine, nortriptyline, phenazine, pindolol, promethazine, propanolol, protriptyline, tioconazole, and trimethoprim on RP18 with phosphate buffer pH 7.4, phosphate-buffered saline, 3-morpholinopropanesulfonic acid pH 7.4, 3-morpholinepropanesulfonic acid + 0.2 % n-decylamine pH 7.4, and phosphate buffer pH 11.0 in pre-saturated chambers. Detection under UV light at 254 nm.

      Classification: 32a
      97 133
      Use of traditional structural descriptors in QSRR analysis of nicotinic acid esters
      Alina Pyka*, J. Sliwiok (*Department of Analytical Chemistry, Faculty of Pharmacy, Silesian Academy of Medicine, 4 Jagiellonska St., 41-200 Sosnowiec, Poland; alinapyka@wp.pl)

      J. Liq. Chrom. & Rel. Technol. 27, 785-798 (2004). TLC of methyl, ethyl, isopropyl, butyl, hexyl, and benzyl nicotinate on silica gel and a mixture of silica gel and kieselguhr (heated at 120 °C for 20 min) with mixtures of n-hexane and acetone in the volume proportions 9:1, 4:1, 7:3, 3:2, 1:1, 2:3, 3:7, 1:4. Detection under UV light at 254 nm.

      Classification: 32a
      98 074
      Simultaneous determination of diclofenac sodium and paracetamol in a pharmaceutical preparation and in bulk drug powder by high-performance thin-layer chromatography
      V.V. DIGHE, R. T. SANE, S. N. MENON, H. N. TAMBE*, S. PILLAI, V. N. GOKARN (*TDM Laboratories, Plot No. 194, Scheme No. 6, Road No. 15, Sion (E), Sion Koliwada, Mumbai-22, India)

      J. Planar Chromatogr. 19, 443-448 (2006). HPTLC of diclofenac sodium and paracetamol (with aceclofenac as internal standard) on silica gel, pre-washed with methanol, in a presaturated twin-trough chamber with toluene - ethyl acetate - methanol - formic acid 50:40:10:1. Quantitative determination by absorbance measurement at 260 nm. The method was validated regarding accuracy and precision.

      Classification: 32a
      98 106
      On problems with liquid chromatographic quantification of chiral 2-arylpropionic acids by use of UV-absorbtion-based detection
      M. SAJEWICZ*, T. KOWALSKA (*Inst. of Chem., Silesian Univ., 9 Szkolna Street, 40-006 Katowice, Poland)

      Acta Chrom. 17, 292-301 (2006). TLC of ibuprofen and naproxen on silica gel pre-washed with methanol - water 9:1 and dryed at ambient temperature for 3 h. The plates were impregnated with a 0.03 M solution of L-arginine in methanol. Development with acetonitrile - methanol - water 5:1:1 containing several drops of glacial acetic acid for S-(+)-ibuprofen, and acetonitrile - methanol - water 10:2:3 containing several drops of glacial acetic acid for S-(+)-naproxen. Densitometry at 200, 205, and 210 nm for S-(+)-ibuprofen and at 202, 215, and 225 nm for S-(+)-naproxen. The investigations were performed by using three independent measurement techniques, all based on UV absorption: HPLC–UV, HPLC–DAD, and TLC–densitometry.

      Classification: 32a
      99 092
      Hydrophobicity study for some pyrazolo-pyridine derivatives by RP-TLC and RP-HPLC
      H. DE MELLO, Aurea ECHEVARRIA* (*Departamento de Química, Intituto de Ciencias Exatas, Universidade Federal Rural do Rio de Janeiro, Seropédica/RJ 23851-970, Brazil; echevarr@ufrrj.br)

      J. Liq. Chromatogr. Relat. Technol. 29, 1317-1330 (2006). TLC of 13 1H-pyrazolo[3,4-b]pyidine derivatives (e. g. 4-(3’- or 4’-X-phenylamino)-5-carbethoxy-1,3-dimethl-1-H-pyrazolo[3,4-b]pyridine derivatives) on hydrocarbon impregnated silica gel with acetone - phosphate buffer (0.01 M; pH 7.4) mixtures with concentrations ranging from 40-70 % in acetone. Detection under UV 254 nm.

      Classification: 32a
      99 132
      Simultaneous HPTLC determination of Frusemide and Spironolactone from pharmaceutical formulation
      M. M. BAING*, V. V. VAIDYA, P. A. CHAMPANERKAR, W. SHAH (*Dept. of Chemistry, S.P. Mandali’s Ramnarain Ruia College, Matunga, mumbai 400019, vaidya_vikas@yahoo.com)

      Indian Drugs 44 (3), 205-208 (2007). HPTLC of frusemide (= furosemide) and spironolactone on silica gel with toluene - acetonitrile - glacial acetic acid 70:30:2, with chamber saturation for 15 min at room temperature. Development over 8 cm, followed by air drying. Quantitative determination by densitometry at 254 nm. Linearity was between 8 - 32 ng/µL and 20 - 80 ng/µL for frusemide and spironolactone respectively. The method was validated for accuracy and precision. The limit of detection and quantification for frusemide was 3 ng/µL and 8 ng/µL respectively, and for spironolactone 2 ng/µL and 6 ng/µL, respectively. Recovery by standard addition was 99.4-101% for both compounds.

      Classification: 32a
      100 076
      Thin-layer chromatography separation of enantiomers of verapamil using macrocyclic antibiotic as a chiral selector
      R. BHUSHAN*, D. GUPTA (*Department of Chemistry, Indian Institute of Technology, Roorkee-247 667, India)

      Biomed. Chromatogr. 19 (6), 474-478 (2005). HPTLC of enantiomers of verapamil on silica gel impregnated with vancomycin, a macrocyclic antibiotic, with acetonitrile - methanol – water 6:1:1. Detection by exposure to iodine vapors.

      Classification: 32a