Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      108 098
      An interlaboratory investigation on the use of high-performance thin-layer chromatography to perform assays of lamivudine-zidovudine, metronidazole, neviparine, and quinine composite samples
      E. KAALE*, P. RISHA, E. REICH, T. P. LAYLOFF (*Muhimbili University of Health and Allied Sciences, School of Pharmacy, Laboratory for Pharmaceutical Analysis, PO Box 65013, Dar es Salaam, Tanzania; elia.kaale@muhas.ac.tz.or elia.kaale@lycos.com)

      J. AOAC Int. 93, 1836-1843 (2010). HPTLC of 1) lamivudine-zidovudine on silica gel with ethyl acetate - toluene - methanol 12:5:3, quantitative determination by absorbance measurement at 289 nm; of 2) metronidazole with ethyl acetate - ammonia 50:1, quantitative determination by absorbance measurement at 313 nm; of 3) neviparine with ethyl acetate - toluene 3:1, quantitative determination by absorbance measurement at 289 nm; and of 4) quinine with ethyl acetate - toluene - acetone 22:3:5, quantitative determination by absorbance measurement at 327 nm in a twin-trough chamber lined with wetted filter paper and saturated for 20 min. The average repeatability (within-laboratory) was 1.9 %, with 73 % less than 2 % and 97 % at 2.6 % or less. The average reproducibility (among-laboratory) was 2.7 %. Mean hRf values for lamivudine, metronidazole, neviparine, quinine, and zidovudine were 19, 28, 34, 33, 57.

      Classification: 32a
      108 116
      Chemical fingerprinting of Turnera diffusa and closely related genera by high-performance thin-layer chromatography
      A.S. RAO*, J. SHAO, T.J. SMILLIE, I.A. KHAN (*National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA)

      Planta Med. 74, 352-353 (2008). HPTLC of tetraphyllin, turneradiffusin, beta-arbutin, terniflorin, echinaticin, turneradin and methanolic extracts of Turnera diffusa on silica gel with ethyl acetate - acetic acid - water 190:10:1. Quantitative determination by densitometric absorbance measurement at 254 nm.

      Classification: 32e
      108 149
      Sensitive quantification of diclofenac and ibuprofen using thin-layer chromatography coupled with a Vibrio fisheri bioluminescence assay
      Andrea SEIGEL, Alexandra SCHROCK, R. HAUSER, B. SPANGENBERG* (*University of Offenburg, Institute of Process Engineering, Badstrasse 24, 77652 Offenburg, Germany, spangenberg@FH-Offenburg.de)

      J. Liq. Chromatogr. Relat. Technol. 34, 817-828 (2011). HPTLC of diclofenac (1) and ibuprofen (2) in aqueous environmental samples, on cyano phase with dichloromethane - methanol - cyclohexane 19:1:8. Detection by dipping into a Vibrio fisheri bacteria suspension for 3 sec. Then a glass plate was placed on top of the layer and a light-sensitive camera was used to measure the luminescence for 1 to 10 min. Linearity was between 10 and 2000 ng/zone. Limits of detection and quantification were 89 and 129 ng/band for (1), and 20 and 26 ng for (2). The coupling of HPTLC with a luminescent bacteria assay is suitable to determine drugs in aqueous environmental samples.

      Classification: 37c
      109 040
      Stability-indicating densitometric HPTLC analysis of brimonidine tartrate in the bulk drug and in eye drops
      P.S. JAIN*, R.N. KHATAL, H.N. NIVANI, S.J. SURANA (*R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur Dist. Dhule 425 405 (M.S.) India; pritash79@yahoo.com)

      J. Planar Chromatogr. 24, 166-171 (2011). HPTLC of brimonidine tartrate as the bulk drug and in formulations on silica gel with methanol - toluene - triethylamine 10:35:2. The hRf value was 48. Quantitative determination by densitometry in absorbance mode at 247 nm. Linearity was between 100 and 600 ng/band (r² = 0.9965). LOD and LOQ were 9 and 28 ng/band, respectively. The intra-day and inter-day precision (%RSD, n = 3) was 1.1-1.2 % and 0.5-1.0 %, respectively. Recovery was between 98.7-100.4 %. The repeatability of application (%RSD, n = 6), was 1.6 %.

      Classification: 17a
      109 072
      Development and validation of HPTLC method for estimation of glycyrrhizic acid in herbal formulation
      S. AHMAD*, Y. KAMAL, M. SINGH, R. R. PARVEEN (*Bioactive Natural Product Lab., Dept. of Pharmacognosy and Phytochemistry Faculty of Pharmacy, Jamia Hamdard, New Delhi)

      Asian Journal of Chemistry 23 (5), 2098-2100 (2011). HPTLC of glycyrrhizic acid in herbal formulation on silica gel with chloroform - glacial acetic acid - methanol - water 15:8:3:2. The hRf value of glycyrrhizic acid was 28. Quantitative evaluation by absorbance measurement at 254 nm. The method was found to be linear in the range of 100-500 ng/band with average recovery between 99-102 %.

      Classification: 11a, 32e
      109 097
      (Determination of stachydrine in Gongkang perfusion by thin-layer chromatography) (Chinese)
      X. MIAO* (Miao Xiaolou), Y. LI (Li Yun), H. PAN (Pan Hu), Y. YANG (Yang Yaoguang), P. SU (Su Peng), Y. WANG (Wang Yu), Z. JIAO (Jiao Zenghua) (*Key Lab. Animal Med. Proj., Lanzhou Inst. Animal & Veterinary Pharm. Sci., Chinese Acad. Agr. Sci., Lanzhou, Gansu 730050, China)

      J. Trad. Chinese Veterinary Med. 5, 53-55 (2010). TLC of stachydrine on silica gel with acetone - ethanol - hydrochloric acid 10:6:1. Detection by spraying with bismuth potassium iodide - 1 % iron(III)chloride in ethanol 5:1 and heating at 100 ºC. Identification by comparison of the hRf value and zone color with the standard. Quantification of stachydrine by densitometry at 510 nm. Precision (%RSD within plate, n = 8) was 3.7 %. Stability of measurement (%RSD within 120 min, n = 5) was 4.5 %. Linearity was in the range of 3.2-38.3 µg/zone (r=0.997, n = 6). The recovery (by standard addition) was 96.6 % with a %RSD of 2.0 % (n = 6).

      Classification: 32e
      109 117
      Identification of 11 marker compounds simultaneously in herb Lancea tibetica by using high-performance thin-layer chromatography
      Z.-H. SONG (Song Zong-Hua), Z.-Z. QIAN (Qian Zhong-Zhi), C. S. RUMALLA, T. J. SMILLIE, I. A. KHAN* (*National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, USA; ikhan@olemiss.edu)

      J. Planar Chromatogr. 24, 312-315 (2011) HPTLC of methanolic extracts of L. tibetica on silica gel (prewashed with methanol) with hexane - ethyl acetate - formic acid 12:7:1 for three furofuranolignans (sylvatesmin, (+)-piperrtol, horsfieldin), beta-sitosterol, and oleanolic acid, and with chloroform - methanol - water - formic acid 70:25:4:2 for four furofuranolignans (phillyrin, tibeticoside A, lantibeside C, and lantibeside), verbascoside and isoverbascoside in a twin-trough chamber with saturation for 20 min. Detection by immersion in ethanolic sulfuric acid for 2 s followed by heating for 5 min at 100 °C. The hRf values were 17, 25, 29, 51, 60, 70, 66, 49, 46, 19, and 21 for sylvatesmin, (+)-piperrtol, horsfieldin, oleanolic acid, beta-sitosterol, phyllirin, tibeticoside A, lantibeside C, lantiboside, verbascoside and isoverbascoside, respectively.

      Classification: 32e
      110 011
      Correlation between ultra-high performance liquid chromatography–tandem mass spectrometry and reversed-phase thin-layer chromatography hydrophobicity data for evaluation of angiotensin-converting enzyme inhibitors absorption
      Jadranka ODOVIC*, B.D. MARKOVIC, R.D. INJAC, S.M. VLADIMIROV, Katarina D. KARLJIKOVIC-RAJIC* (*Dep. of Anal. Chem., Univ. of Belgrade, Faculty of Pharm., Vojvode Stepe 450, 11221 Belgrade, Serbia)

      J. of Chromatogr. A 1258, 94-100 (2012). Study of seven angiotensin-converting enzyme (ACE) inhibitors (enalapril, quinapril, fosinopril, lisinopril, cilazapril, ramipril, benazepril) to evaluate the correlation between their absorption and UHPLC–MS and RP-TLC hydrophobicity data (f0 or C0 parameters, respectively). Their absorption values were in the range of 25–60 % and calculated KOWWIN logP values ranged from -0.94 to 6.61. In order to obtain reliable correlation (r2 = 0.7208) between absorption and ACE inhibitors lipophilicity the solubility data (logS) must be considered, as independent variable, simultaneously with KOWWIN logP. Study of the relationships between literature available and absorption data predicted by multiple linear regression (MLR) using logS values besides chromatographically obtained hydrophobicity parameters C0 (r2 = 0.6424) or f0 (r2 = 0.6762) indicates that these parameters could be used in ACE inhibitors absorption evaluation. The UHPLC–MS method provides the direct application of experimentally obtained f0 values. Mathematical conversion of C0 parameters to logC0 values was necessary based on requisite for probability value of regression analysis (P < 0.05) for better MLR correlation of ACE inhibitors absorption with C0 parameters (RP-TLC) and logS. Definition of the accordance and differences between hydrophobicity parameters obtained by UHPLC–MS and RP-TLC.

      Classification: 2
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