Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      109 103
      Development and validation of an HPTLC method for determination of olanzapine in formulations
      R.B. PATEL, M.R. PATEL*, K.K. BHATT, B.G. PATEL (*Sardar Patel University, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar-388 121, Gujarat, India; rashmru@gmail.com)

      J. AOAC Int. 93, 811-819 (2010). HPTLC of olanzapine on silica gel (prewashed twice with methanol) with methanol - ethyl acetate 4:1 in a twin-trough chamber saturated for 20 min at 25 +/- 2 °C. Quantitative determination by densitometry in absorbance mode at 285 nm. The hRf was 35. Linearity was between 100 and 600 ng/band for olanzapine. LOD was 24 ng/band and LOQ 91 ng/band. The average recovery (n = 6) was 100.4 %. The %RSD of intra-day and inter-day precision (n = 5) was between 0.2-1.4 %.

      Classification: 32a
      109 125
      (Identification of quercetin in Saururus chinensis (Lour) Baill by thin-layer chromatography) (Chinese)
      X. WANG* (Wang Xiaofei), L. YU (Yu Ling), H. DU (Du Huashuang), J. WANG ( Wang Jie) (*Inst. for Drug Cont. of People’s Armed Police Forces, Beijing, 102613 China)

      Chinese J. of Ethnomed. & Ethnopharm. 23, 61-62 (2010). Preparation of the samples by extracting Saururus chinensis (Lour.) Baill with methanol - 25 % hydrochloric acid 4:1 and sonication for 1 h (these were the best conditions of five different solvent compositions and different sonication times investigated). TLC of the obtained extracts on silica gel with 1) petroleum ether (60-90 ºC) - acetone 5:2, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 ºC; 2) toluene - ethyl acetate - formic acid 5:2:1, detection by spraying with 1 % aluminium chloride in ethanol and evaluation under UV 366 nm; 3) hexane - ethyl acetate - formic acid 70:50:8, detection by spraying with 1 % aluminium chloride in ethanol and heating at 105 ºC, detection under daylight and UV 366 nm; 4) toluene - ethyl acetate - formic acid 5:4:1 saturated with hydrochloric acid, detection under daylight and UV 366 nm. System 4) provided the best separation and was most practical. Identification of quercetin by fingerprint comparison with the standard.

      Classification: 32e
      110 021
      Time resolved chromatograms in ultra-thin layer chromatography
      A.J. OKO, S.R. JIM, M.T. TASCHUK, M.J. BRETT* (*Univ. of Alberta, Dep. of ECE, 2nd Floor ECERF, Edmonton, AB, Canada T6G 2V4)

      J. of Chromatogr. A 1249, 226-232 (2012). Ultrathin-layer chromatography (UTLC) is a recently developed analytical method intended for compact, rapid separations of nanolitre analyte volumes. However, new measurement techniques compatible with the millimetre length scales and rapid separation dynamics observed in UTLC are required for optimizing the performance of this method. A measurement system which records UTLC separations in full color with 32 µm spatial resolution and 33 ms temporal resolution has been designed, implemented and characterized. It features analysis of multiple tracks per plate, filtering of analyte zones by color, and automatic generation of time-resolved figures. By capture a wealth of information from a UTLC separation it provides insight into UTLC physics and improves the analytical performance.

      Keywords: HPTLC
      Classification: 3
      110 042
      Thin-layer chromatography of amino acids - a review
      S. BHAWANI*, M. MOHAMAD, O. SULAIMAN, R. HASHIM, A. MOHAMMAD, S. HENA (*Bhawani, School of Chemical Sciences, University Sains Malaysia, 11800, Pulau Pinang, Malaysia, sabhawani@gmail.com)

      J. Liq. Chromatogr. Relat. Technol. 35, 1497-1516 (2012). The authors reviewed stationary phases, solvent systems, and detection reagents developed for the analysis of amino acids. Polar and non-polar layers as well as impregnated layers mainly with metal ions and also with chiral agents were described for the separation and identification of amino acids. On the other hand, over fifty mobile phases were reviewed for the analysis of amino acids, with a recent tendency in the use of surfactants as less toxic reagents. Methodologies for the separation of amino acid enantiomers, such as the use of beta-cyclodextrin as chiral mobile phase as well as derivatization methods such as iodine azide reaction to enhance sensitivity in detection were also described. TLC has a privileged position due to its simplicity, convenience, and cost-effectiveness for separation of amino acids.

      Keywords: review HPTLC
      Classification: 1b, 18a
      110 061
      Densitometric thin-layer chromatography of protease inhibitors in pharmaceutical preparations
      Anindita BEHERA*, Dannana SANKAR, S. MOITRA, S. SI (*School of Pharmaceutical Sciences, Siksha “O” Anusandhan University, Bharatpur, Ghatikia, Bhubaneswar, Orissa, India, anindita02@gmail.com)

      J. Planar Chromatogr. 25, 374-379 (2012). HPTLC of atazanavir sulfate (1) and ritonavir (2) in combined dosage forms on silica gel with toluene - methanol - glacial acetic acid - ethyl acetate 14:1:3:4. Quantitative determination by absorbance measurement at 254 nm. The hRf values for (1) and (2) were 50 and 63, respectively. Linearity was in the range of 30-300 ng/zone for (1) and 10-100 ng/zone for (2). The limit of detection and quantification was 16 and 49 ng/zone for (1) and 18 and 55 ng/zone for (2), respectively. The intermediate/inter-day/intra-day precision was below 0.7 % (n=6). Recovery for (1) and (2) was in the range of 99.6-100.0 %.

      Classification: 32a
      110 099
      Development and validation of reverse phase high-performance liquid chromatographic and high-performance thin-layer chromatographic methods for simultaneous estimation of melitracen hydrochloride and flupentixol hydrochloride in bulk and combined dosage f
      R. LIMGAVKAR*, P. TRIVEDI, A. PATEL (*Institute of Pharmaceutical Education and Research, Sector-23, Gh-6, Gandhinagar 382023, Gujarat, India, ratnalimgavkar@gmail.com)

      J. Liq. Chromatogr. Relat. Technol. 35, 2753-2764 (2012). HPTLC of melitracen hydrochloride (1) and flupentixol hydrochloride (2) on silica gel with methanol - chloroform - toluene 2:9:9 + 1 drop ammonia. Quantitative determination by absorbance measurement at 291 nm. The hRf value of compounds (1) and (2) were 53 and 34 and selectivity regarding matrix was given. Linearity was in the range of 1600-6400 ng/band and 80-320 ng/band for (1) and (2), respectively. Limit of detection was found to be 27 ng/band and 5 ng/band for (1) and (2), respectively. Limit of quantification was found to be 82 ng/band and 14 ng/band for (1) and (2), respectively. The intermediate/inter-day/intra-day precision was below 0.2 % for (1) and 1.1 % for (2) (n=3). Recovery (by standard addition) was between 99.1 and 101.8 % for both (1) and (2). The method showed comparable results with HPLC.

      Classification: 32a
      110 126
      Antiurolithiatic activity of saponin rich fraction from the fruits of Solanum xanthocarpum Schrad
      P. PATEL*, M. PATEL, B. VYAS, D. SHAH, T. GANDHI (*Department ofPharmacology, MalibaPharmacyCollege, Bardoli-MhuvaRoad, Tarsadi, Bardoli, District-Surat, Gujarat 394350, India, paras.pharm@gmail.com)

      & Wendl. (Solanaceae) against ethylene glycol induced urolithiasis in rats. J. Ethnopharmacol. 138, 160-170 (2012). HPTLC of solasodine in the fruits of Solanum xanthocarpum on silica gel with toluene - ethyl acetate - diethylamine 12:1:1. Quantitative determination by absorbance measurement at 200 nm. The hRf of solasodine was 52.

      Classification: 32e
      110 165
      TLC-densitometric quantification of negundoside, ursolic acid, eugenol, lupeol, and beta-sitosterol using HPTLC from Vitex Negundo leaves
      H. YADAV, P. MUNGARA, M. JIVRAJANI, M. NIVSARKAR, S. ANANDJIWALA* (*Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad–380054, Gujarat, India, drsheetalanand@yahoo.co.in)

      J. Liq. Chromatogr. Relat. Technol. 35, 1565-1584 (2012). HPTLC of negundoside (1), ursolic acid (2), eugenol (3), lupeol (4), and beta-sitosterol (5) in the leaves of Vitex Negundo on silica gel with toluene - methanol 9:1. Detection by dipping in anisaldehyde sulfuric acid reagent for approximately 1 min, followed by heating at 100 °C for 5 min. Quantitative determination by absorbance measurement at 525 nm. The hRf value of compounds (1) to (5) were 47, 61, 56, 54 and 38, and selectivity regarding matrix was given. Linearity was in the range of 200-800 ng/zone for (1), 72-576 ng/zone for (2), 200-1000 ng/zone for (3), 150-900 ng/zone for (4) and 80-480 ng/zone for (5). Limits of detection and quantification were 80 and 200 ng/zone for (1), 18 and 72 ng/zone for (2), 60 and 200 ng/zone for (3), 50 and 100 ng/zone for (4) and 20 and 60 ng/zone for (5), respectively. The method provides acceptable intra-day and inter-day precision for (1) to (5). The average recoveries for compounds (1) to (5) were found to be 99.9, 100.1, 99.7, 100.0, and 99.9 %, respectively.

      Classification: 32e
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