Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
  • Keyword register: select an initial character and browse associated keywords
  • Search by CBS edition: Select a CBS edition and find all related publications

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      109 123
      Quantitative simultaneous determination of amlodipine, valsartan, and hydrochlorotiazide in “exforge hct” tablets using high-performance liquid chromatography and high-performance thin-layer chromatography
      S. VARGHESE*, T. KOCHUPAPPY (*Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu, India, susheeljv@yahoo.com)

      J. Liq. Chromatogr. Relat. Technol. 34, 981-994 (2011). HPTLC of amlodipine (1), valsartan (2), and hydrochlorotiazide (3) in tablets on silica gel with chloroform - glacial acetic acid - n-butyl acetate 4:2:1. Quantitative determination by absorbance measurement at 320 nm. The hRf values of compounds (1) - (3) were 18, 40 and 75, respectively. Linearity was between 0.2-0.6 µg/zone for (1), 6.4-19.2 µg/zone for (2) and 0.5-1.5 µg/zone for (3). LOD and LOQ were found to be 90-200 ng/zone for (1), 3200-6400 ng/zone for (2) and 30-60 ng/zone for (3). Intra-day and inter-day precision (%RSD, n = 6) was below 0.8 %. Recovery (by standard addition) ranged from 98 to 101 %.

      Classification: 32a
      110 018
      Stable, microfabricated thin-layer chromatography plates without volume distortion on patterned, carbon and Al2O3-primed carbon nanotube forests
      D.S. JENSEN, Supriya S. KANYAL, V. GUPTA, M. A. VAIL, A.E. DADSON, M. ENGELHARD, R. VANFLEET, R.C. DAVIS, M.R. LINFORD* (*Dep. of Chem. & Biochem., Brigham Young Univ., Provo, UT 84602, USA)

      J. of Chromatogr. A 1257, 195-203 (2012). Based on the recent description of the fabrication of TLC plates from patterned carbon nanotube (CNT) forests via direct infiltration/coating of the CNTs by low pressure chemical vapor deposition of silicon from SiH4, followed by high temperature oxidation of the CNTs and Si, an improved microfabrication process for the preparation of these TLC plates has been presented. First, deposition of a few nanometers of carbon and/or a thin film of Al2O3 on the CNTs, confirmation of the presence of additional oxygen after carbon deposition by X-ray photoelectron spectroscopy, after priming, coating of the plates by rapid, conformal deposition of an inorganic material that does not require subsequent oxidation, i.e., by a fast pseudo atomic layer deposition (?-ALD) of SiO2 from trimethylaluminum and tris(tert-butoxy)silanol and faithful reproduction of the features in the masks is still observed after oxidation. Fast, highly efficient separations of the fluorescent dyes eosin Y disodium and sulforhodamine B were achieved on amino phase with LiCl - methanol 1:100 over 30 mm migration distance.

      Keywords: HPTLC
      Classification: 3b, 30
      110 040
      TLC-densitometric determination of tolperisone and its impurities 4-methylpropiophenone and piperidine in pharmaceutical preparations
      U. HUBICKA, J. KRZEK*, Barbara WITEK (*Department of Inorganic and Analitycal Chemistry, Medical College of Jagiellonian University, 9 Medyczna Str, 30-688 Krakow, Poland, jankrzek@cm-uj.krakow.pl)

      J. Liq. Chromatogr. Relat. Technol. 35, 1325-1335 (2012). HPTLC of tolperisone (1) and its impurities 4-methylpropiophenone (2) and piperidine (3) on silica gel with cyclohexane-1,4 - dioxane - isopropanol - ethanol 32:1:2:8 + 1 drop glacial acetic acid. Detection by dipping in a 0.3 % methanolic ninhydrin solution for 10 min, followed by heating at 105 °C for 5 min. Quantitative determination by absorbance measurement at 570 nm. The hRf values of compounds (1) to (3) were 10, 76 and 60, respectively. Linearity was in the range of 60-1500 ng/band for (1), 90-400 ng/band for (2) and 40-250 ng/band for (3). Limits of detection and quantification were 20 and 60 ng/band for (1), 30 and 90 ng/band for (2) and 20 and 40 ng/band for (3), respectively.The intermediate precisions (level 2) for (1) to (3) were 1.6 %, 2.6 % and 2.4 % (n=5), respectively. Recovery for compounds (1) to (3) was between 84.6 and 99.7 %.

      Classification: 17
      110 059
      A validated high-throughput chromatographic method for simultaneous determination of vitamin K homologues
      N. ATIA*, S. AHMED (*Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt, nohanahedj@yahoo.com)

      J. Liq. Chromatogr. Relat. Technol. 35, 484-498 (2012). HPTLC of vitamin K homologues including phylloquinone (1), menaquinone-4 (2), and menaquinone-7 (3) on silica gel with methanol - ethanol - isopropanol - water 15:1:1:3. Quantitative determination by absorbance measurement at 254 nm. The hRf values of compounds (1) to (3) were 56, 43 and 23, respectively. Linearity was in the range of 1-200 ng/band. Limits of detection and quantification were in the range of 0.2-0.9 and 0.7-2.5 ng/band, respectively. The intermediate/inter-day/intra-day precisions for (1) to (3) were in the range of 0.5-1.3 % (n=5). Recoveries were ranged from 95.3 to 100.8 %.

      Classification: 32a
      110 090
      Rapid validated RP-HPTLC method for the quantification of major bioactive constituents of Crataegus oxyacantha L
      P. KAUR, A. CHAUDHARY, A. KATIYAR, B. SINGH*, R. SINGH (*Natural Plant Products Division, Institute of Himalayan Bioresource Technology, (CSIR) Palampur, Himachal Pradesh, 176061, India, bikram_npp@rediffmail.com)

      J. Planar Chromatogr. 25, 415-419 (2012). HPTLC of apigenin (1), quercetin (2), hyperoside (3), vitexin (4) and vitexin-2”-O-rhamnoside (5) on silica gel with acetonitrile - methanol - water 1:1:2 + 1 drop formic acid. Quantitative determination by absorbance measurement at 254 nm. The hRf of (1) to (5) were 12, 20, 48, 53 and 59, respectively. Linearity was in the range of 400-1250 ng/zone for (1) and (2) and 800-2500 ng/zone for (3) to (5). Limits of detection and quantification were 100 and 310 ng/zone for (1), 200 and 630 ng/zone for (2) and (3) and 300 and 960 ng/zone for (4) and (5), respectively, The intermediate/inter-day/intra-day precision was below 2.2 % (n=3). Recovery for all (1) to (5) was between 97.1 and 100.2 %.

      Classification: 32e
      110 124
      Phyllanthus amarus - ethnomedicinal uses, phytochemistry and pharmacology - a review
      J. PATEL, P. TRIPATHI, V. SHARMA, N.CHAUHAN, V. DIXIT* (*Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, M.P., India, vkdixit2011@rediffmail.com)

      J. Ethnopharmacol. 138, 286-313 (2011). The review covers literature across from 1980 to 2011. HPTLC studies of Phyllanthus amarus such as fingerprint profiles and detection of phyllanthin and hypophyllanthin as marker components were reviewed. Comparative results with HPLC were also described.

      Classification: 1, 32e
      110 150
      Stability-indicating HPTLC method for the determination of atorvastatin and ezetimibe - application to pharmaceutical dosage forms
      S. WALODE*, A. KASTURE, S. WADODKAR (*Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (Bk), Lonavala, Pune 410401, Maharashtra, India, sanjuwalode@rediffmail.com)

      J. Planar Chromatogr. 25, 81-84 (2012). HPTLC of atorvastatin (1) and ezetimibe (2) on silica gel with methanol - toluene - chloroform - triethylamine 2:16:1:1. Quantitative determination by absorbance measurement at 259 nm. The hRf values of compounds (1) and (2) were 7 and 37, respectively. Linearity was in the range of 500-1500 ng/band for both (1) and (2). Intermediate/inter-day/intra-day precision was below 2 % (n=3). Mean recovery was 99.7 % for both active agents.

      Classification: 32a
      111 014
      In-situ clean-up and OPLC fractionation of chamomile flower extract to search active components by bioautography
      E. MINCSOVICS*, P. OTT, A. ALBERTI, A. BOSZORMENYI, E. HETHELYI, E. SZOKE, A. KERY, E. LEMBERKOVICS, A. MORICZ (*Department of Genetics and Plant Breeding, Faculty of Horticultural Sciences, Corvinus University, Villányi Str. 29–45, 1118 Budapest, Hungary, emil.mincsovics@t-online.hu)

      J. Planar Chromatogr. 26, 172-179 (2013). OPLC with on-line detection and fractionation, in-situ sample clean-up in the planar layer adsorbent bed, direct bioautography (DB), OPLC–MS, solid phase microextraction (SPME)–GC–MS, and LC–MS/MS for the bioassay-guided isolation and characterization of bioactive compounds from chamomile flower extract. The bioassay-guided isolation of antibacterial chamomile components was based on OPLC separation with on-line detection and fractionation combined with previous sample clean-up in-situ in the adsorbent bed after sample application. First the adsorbent layer was partially pre-weted between the edge of the layer and the sample application zone with the goal to fill up the “dead” area behind the trough, which leads the components to leave the adsorbent layer during the clean-up step. With this process, the zone behind the trough can be protected from stucking of any components in it, otherwise the stucked compounds could be detected continuously during the separation/detection/fraction collection. During the in-situ sample clean-up the mobile phase flow was in the opposite direction, from outlet toward inlet of the chamber. In this step the load of the adsorbent can be decreased for the fractionation, which is done in the normal direction of the mobile phase.

      Classification: 4e
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