Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      110 040
      TLC-densitometric determination of tolperisone and its impurities 4-methylpropiophenone and piperidine in pharmaceutical preparations
      U. HUBICKA, J. KRZEK*, Barbara WITEK (*Department of Inorganic and Analitycal Chemistry, Medical College of Jagiellonian University, 9 Medyczna Str, 30-688 Krakow, Poland, jankrzek@cm-uj.krakow.pl)

      J. Liq. Chromatogr. Relat. Technol. 35, 1325-1335 (2012). HPTLC of tolperisone (1) and its impurities 4-methylpropiophenone (2) and piperidine (3) on silica gel with cyclohexane-1,4 - dioxane - isopropanol - ethanol 32:1:2:8 + 1 drop glacial acetic acid. Detection by dipping in a 0.3 % methanolic ninhydrin solution for 10 min, followed by heating at 105 °C for 5 min. Quantitative determination by absorbance measurement at 570 nm. The hRf values of compounds (1) to (3) were 10, 76 and 60, respectively. Linearity was in the range of 60-1500 ng/band for (1), 90-400 ng/band for (2) and 40-250 ng/band for (3). Limits of detection and quantification were 20 and 60 ng/band for (1), 30 and 90 ng/band for (2) and 20 and 40 ng/band for (3), respectively.The intermediate precisions (level 2) for (1) to (3) were 1.6 %, 2.6 % and 2.4 % (n=5), respectively. Recovery for compounds (1) to (3) was between 84.6 and 99.7 %.

      Classification: 17
      110 059
      A validated high-throughput chromatographic method for simultaneous determination of vitamin K homologues
      N. ATIA*, S. AHMED (*Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt, nohanahedj@yahoo.com)

      J. Liq. Chromatogr. Relat. Technol. 35, 484-498 (2012). HPTLC of vitamin K homologues including phylloquinone (1), menaquinone-4 (2), and menaquinone-7 (3) on silica gel with methanol - ethanol - isopropanol - water 15:1:1:3. Quantitative determination by absorbance measurement at 254 nm. The hRf values of compounds (1) to (3) were 56, 43 and 23, respectively. Linearity was in the range of 1-200 ng/band. Limits of detection and quantification were in the range of 0.2-0.9 and 0.7-2.5 ng/band, respectively. The intermediate/inter-day/intra-day precisions for (1) to (3) were in the range of 0.5-1.3 % (n=5). Recoveries were ranged from 95.3 to 100.8 %.

      Classification: 32a
      110 090
      Rapid validated RP-HPTLC method for the quantification of major bioactive constituents of Crataegus oxyacantha L
      P. KAUR, A. CHAUDHARY, A. KATIYAR, B. SINGH*, R. SINGH (*Natural Plant Products Division, Institute of Himalayan Bioresource Technology, (CSIR) Palampur, Himachal Pradesh, 176061, India, bikram_npp@rediffmail.com)

      J. Planar Chromatogr. 25, 415-419 (2012). HPTLC of apigenin (1), quercetin (2), hyperoside (3), vitexin (4) and vitexin-2”-O-rhamnoside (5) on silica gel with acetonitrile - methanol - water 1:1:2 + 1 drop formic acid. Quantitative determination by absorbance measurement at 254 nm. The hRf of (1) to (5) were 12, 20, 48, 53 and 59, respectively. Linearity was in the range of 400-1250 ng/zone for (1) and (2) and 800-2500 ng/zone for (3) to (5). Limits of detection and quantification were 100 and 310 ng/zone for (1), 200 and 630 ng/zone for (2) and (3) and 300 and 960 ng/zone for (4) and (5), respectively, The intermediate/inter-day/intra-day precision was below 2.2 % (n=3). Recovery for all (1) to (5) was between 97.1 and 100.2 %.

      Classification: 32e
      110 124
      Phyllanthus amarus - ethnomedicinal uses, phytochemistry and pharmacology - a review
      J. PATEL, P. TRIPATHI, V. SHARMA, N.CHAUHAN, V. DIXIT* (*Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, M.P., India, vkdixit2011@rediffmail.com)

      J. Ethnopharmacol. 138, 286-313 (2011). The review covers literature across from 1980 to 2011. HPTLC studies of Phyllanthus amarus such as fingerprint profiles and detection of phyllanthin and hypophyllanthin as marker components were reviewed. Comparative results with HPLC were also described.

      Classification: 1, 32e
      110 150
      Stability-indicating HPTLC method for the determination of atorvastatin and ezetimibe - application to pharmaceutical dosage forms
      S. WALODE*, A. KASTURE, S. WADODKAR (*Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (Bk), Lonavala, Pune 410401, Maharashtra, India, sanjuwalode@rediffmail.com)

      J. Planar Chromatogr. 25, 81-84 (2012). HPTLC of atorvastatin (1) and ezetimibe (2) on silica gel with methanol - toluene - chloroform - triethylamine 2:16:1:1. Quantitative determination by absorbance measurement at 259 nm. The hRf values of compounds (1) and (2) were 7 and 37, respectively. Linearity was in the range of 500-1500 ng/band for both (1) and (2). Intermediate/inter-day/intra-day precision was below 2 % (n=3). Mean recovery was 99.7 % for both active agents.

      Classification: 32a
      111 014
      In-situ clean-up and OPLC fractionation of chamomile flower extract to search active components by bioautography
      E. MINCSOVICS*, P. OTT, A. ALBERTI, A. BOSZORMENYI, E. HETHELYI, E. SZOKE, A. KERY, E. LEMBERKOVICS, A. MORICZ (*Department of Genetics and Plant Breeding, Faculty of Horticultural Sciences, Corvinus University, Villányi Str. 29–45, 1118 Budapest, Hungary, emil.mincsovics@t-online.hu)

      J. Planar Chromatogr. 26, 172-179 (2013). OPLC with on-line detection and fractionation, in-situ sample clean-up in the planar layer adsorbent bed, direct bioautography (DB), OPLC–MS, solid phase microextraction (SPME)–GC–MS, and LC–MS/MS for the bioassay-guided isolation and characterization of bioactive compounds from chamomile flower extract. The bioassay-guided isolation of antibacterial chamomile components was based on OPLC separation with on-line detection and fractionation combined with previous sample clean-up in-situ in the adsorbent bed after sample application. First the adsorbent layer was partially pre-weted between the edge of the layer and the sample application zone with the goal to fill up the “dead” area behind the trough, which leads the components to leave the adsorbent layer during the clean-up step. With this process, the zone behind the trough can be protected from stucking of any components in it, otherwise the stucked compounds could be detected continuously during the separation/detection/fraction collection. During the in-situ sample clean-up the mobile phase flow was in the opposite direction, from outlet toward inlet of the chamber. In this step the load of the adsorbent can be decreased for the fractionation, which is done in the normal direction of the mobile phase.

      Classification: 4e
      111 033
      Separation of amino acid 2,4-dinitrophenyl-5-L-valine amide diastereomeric derivatives with high-performance planar chromatography and pressurized planar electrochromatography
      B. POLAK*, K. BALASA, T. DZIDO (*Department of Physical Chemistry, Medical University of Lublin, Chodyki 4A, 20-093 Lublin, Poland, beata.polak@umlub.pl)

      J. Planar Chromatogr. 26, 180-189 (2013). HPTLC of 2,4-dinitrophenyl-5-L-valine amide derivatives of some amino acids (leucine, isoleucine, valine, asparagine, cysteine, tryptophane) L and D-enantiomers on RP-18 with aqueous buffer pH 2.2 (1.47 mM citric acid, 0.06 mM disodium hydrogen phosphate) and acetonitrile 50 %. The statistic evaluation of the migration distance compared with pressurized planar electrochromatography (PPEC) shows similar RSD.

      Classification: 18a
      111 052
      Bioautographic HPTLC assays for screening of Gabonese medicinal plants used against Diabetes mellitus
      Huguette AGNANIET, Anita ANKLI* (*CAMAG Laboratory, Sonnenmattstr. 11, 4132 Muttenz, Switzerland, anita.ankli@camag.com)

      CBS 110, 5-7 (2013). HPTLC of extracts of (1) Nauclea diderrichii, (2) Sarcocephalus pobeguinii, (3) Hua gabonii, (4) Morinda lucida, and (5) Momordica foetida on silica gel with A) toluene - ethyl acetate 19:1; B) chloroform - methnaol - water 35:15:2; C) ethyl acetate - acetic acid - formic acid - water 100:11:11:27, D) acetonitrilie - water - formic acid 15:4:1, and E) 1-butanol - acetic acid - water 7:1:2. For (1) mobile phases B and C were best suited, for (2) mobile phase B, for lipophilic compounds of the essential oil of (3) mobile phase A and for (4) and (5) mobile phase B. Bioautographic analysis using alpha- and beta-glucosidase enzym assays, acetylcholinesterase inhibition assay, and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical reagent for detecting radical scavenging activity.

      Classification: 32e
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