Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      102 066
      Estimation of adenosine and its major metabolites in brain tissues of rats using high-performance thin-layer chromatography - densitometry
      A.K. Kumar*, K. Manninder (*Kulkarni S K Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India)

      J. Chromatogr. A 1209 (1-2), 230-237 (2008). TLC of purines (adenosine and its major metabolites, inosine, and hypoxanthine) in rat brain tissue preparations, on silica gel with a two-step gradient mobile phase consisting of (1) n-butanol – water – acetonitrile - 10% ammonia - acetic acid 10:4:8:2:1 and (2) n-butanol – chloroform – acetonitrile - 10 % ammonia - acetic acid 10:4:8:2:1. Quantitative determination by absorbance measurement at 258 nm (via peak area). Application of the method to estimate the endogenous purines in discrete regions of rat brain. Development of a novel protocol for tissue preparation using 0.1 M HCl and 0.15 M NaOH solutions in 60 % methanol, which provided well-resolved peaks and high recoveries.

      Classification: 21a
      102 100
      Chemical fingerprinting of Lawsonia inermis L
      Francesca GALLO*, G. MULTARI, M. GIAMBENEDETTI, E. FEDERICI (*Dipartimento del Farmaco, Istituto Superiore di Sanita, Roma, Italy, Francesca.gallo@iss.it)

      using HPLC, HPTLC and densitometry. Phytochem. Anal. 19, 550-559 (2008). HPTLC of the leaves of Lawsonia inermis L., on silica gel with ethyl acetate – formic acid – water 82:9:9 followed by drying at 110 °C for 15 min. Detection by spraying with diphenylborinic acid aminoethylester 0.5 % in ethyl acetate, followed by drying and dipping into macrogol reagent (1 g polyethylene glycol 400 in 20 mL dichloromethane). Quantitative determination by absorbance measurement at 337 nm. Chemical fingerprint was used for quality evaluation of herbal products and detection of adulteration. Comparison with an HPLC method gave comparable results.

      Classification: 32e
      102 121
      Validated HPTLC method and content uniformity test for analysis of telmisartan and hydrochlorothiazide in tablet dosage forms
      S. Mogre*, B. Mehta (*Dept. of Chemistry, University of Mumbai, Vidyanagari, Santacruz (E) Mumbai 400098, India)

      J. Pharm. Res. 7(2), 126-128 (2008). HPTLC on silica gel with acetone - chloroform - ethyl acetate - methanol 6:6:6:1. Quantitative determination by absorbance measurement at 280 nm. The hRf value for telmisartan was 27 and for hydrochlorothiazide 45. The regression curve shows good linear relationship in the concentration range of 25.5 - 128.0 µg for hydrochlorothiazide and 81.6 - 408.0 µg for telmisartan. The content uniformity test was carried out as per the USP specification of the content uniformity test. The percent drug estimated from the marketed formulations were found to be in the range 99.3 and 100.5 for both drugs. The percent recoveries of drug carried out by the standard addition method was found to be 100.3 and 99.4 for hydrochlorothiazide and telmisartan respectively. The proposed method was found suitable for routine quality control and content uniformity tests.

      Classification: 32a
      102 139
      Validated high performance thin layer chromatography method for simultaneous estimation of rofecoxib and tizanidine hydrochloride in pure and tablet dosage forms
      C. ROOSEWELT*, N. HARIKRISHNAN, P. MUTHUPRASANNA, P. SHANMUGAPANDIYAN, V. GUNASEKARAN (*Dept. of Pharmaceutical Analysis, Vel’s College of Pharmacy, Pallavaram, Chennai 600117, India, kalavaivgs30@rediffmail.com)

      Asian J. Chem. 19(6), 4286 - 4290 (2008). HPTLC of rofecoxib and tizanidine hydrochloride on silica gel with acetone - methanol 1:1. The method was linear in the range of 2200-3300 ng/spot and 180-260 ng/spot for rofecoxib and tizanidine respectively. The recovery was between 99.7 and 102.6 % for both compounds. The method was useful for the simultaneous estimation of the drug content in pure and tablet dosage form.

      Classification: 32a
      102 157
      HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC ESTIMATION OF LANSOPRAZOLE AND DOMPERIDONE IN TABLETS
      J. Susheel*, M. Lekha, T. Ravi (*Dept. of Pharmaceutical Analysis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641044, India)

      Ind. J. Pharm. Sci. 69 (5), 689 - 686 (2007). A simple, fast precise and accurate HPTLC method has been developed for the simultaneous estimation of lansoprazole and domperidone in tablet formulations. This method allows the determination of 100-500 ng/spot of lansoprazole and 100-500 ng/spot of domperidone. HPTLC on silica gel with n-butanol - acetic acid - water 36:12:1:2. Quantitative determination by absorbance measurement at 288 nm. The hRf value of lansoprazole was 78 and of domperidone 21. The limit of detection and quantification for lansoprazole was 10 ng/spot and 40 ng/spot, and for domperidone 30 ng/spot and 65 ng/spot, respectivey. The method was suitable for routine quality control.

      Classification: 32a
      103 092
      Stability-indicating high-performance thin-layer chromatographic determination of levonorgestrel and ethinyloestradiol in bulk drug and in low-dosage oral contraceptives
      A.R. FAKHARI*, A.R. KHORRAMI, M. SHAMSIPUR (*Department of Chemistry, Shahid Beheshti University, Tehran, Iran)

      Anal. Chim. Acta, 572 (2), 237-242 (2006). Presentation of a stability-indicating method for simultaneous determination of the steroidal hormones levonorgestrel and ethinyloestradiol both in bulk drug and in low-dosage oral contraceptives by HPTLC on silica gel with hexane - chloroform - methanol 4:12:1. The hRf value of levonorgestrel was 65 and of ethinyloestradiol 43. The compounds were well separated from their degradation products. Quantitative determination by absorbance measurement at 225 nm. Linearity of levonorgestrel and ethinyloestradiol was 200–800 and 40–160 ng/spot, respectively.

      Classification: 32c
      103 124
      Development of eastern blotting technique for sennoside A and sennoside B using anti-sennoside A and anti-sennoside B monoclonal antibodies
      O. MORINAGA, T. UTO, S. SAKAMOTO, W. PUTALUN, S. LHIEOCHAIPHANT, H. TANAKA, Y, SHOYAMA* (*Faculty of Pharmaceutical Science, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan; shoyama@niu.ac.jp)

      Phytochem. Anal. 20, 154-158 (2009). TLC of the purgative constituents of rhubarb (sennoside A and sennoside B) on silica gel with 1-propanol - ethyl acetate - water - acetic acid 40:40:30:1. After drying detection by spraying with 10 % sulfuric acid and heating. For the eastern blotting assay the developed TLC plate was dried and sprayed with isopropanol - methanol - water 1:4:16. Transfer by using a PVDF membrane sheet for further treatment.

      Classification: 3e, 32e
      103 153
      (Study of the quality standard for Qufu Zhuanggu capsules) (Chinese)
      P. TENG (Teng Peng)*, X. ZHANG (Zhang Xu), Y. DENG (Deng Yun) (*Pharm. Coll., Chengdu Chinese Trad. & Pharm. Univ., Chengdu, Sichuan 610075, China)

      Chinese J. Modern Appl. Pharm. 25 (1), 66-69 (2008). TLC of Qufu Zhuanggu capsule extracts on silica gel with 1) n-hexane - ethyl acetate 4:1; 2) benzene - ethyl acetate 9:1; 3) chloroform - methanol 19:1; 4) cyclohexane - ethyl acetate 5:2; 5) n-hexane - acetone 3:1. Detection 1) under UV 365 nm; 2) by spraying with 10 % sulfuric acid in ethanol and heating at 105 ºC until the spot were visualized; 3) by treatment with ammonia vapors for 10 min; 4) by spraying with 20 % HClO4 in ethanol. Identification by comparison of the chromatograms with those of the standard psoralen.

      Classification: 32e
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