Cumulative CAMAG Bibliography Service CCBS
Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.
The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:
- Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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Journal of Pharmacy Research 2(1), 189-195 (2009). A validated HPTLC method has been developed for simultaneous estimation of valdecoxib and tizanidine in dosage form. HPTLC on silica gel with toluene - methanol - ethyl acetate 2:2:1. The compounds were well separated as compact bands. The method was linear in the range of 10-100 ng/band for tizanidine and 100-1000 ng/band for valdecoxib. The recovery was in the range of 99.3-101.2 %. Densitometric quantification at 254 nm. The method is suitable for quality control of combined dosage form.
Pharmaceutical Methods 1(1), 39-43 (2010). TLC on silica gel with acetonitrile - chloroform 5:6. The hRf value of irbesartan was 27 and of hydrochlorothiazide 45. Densitometric evaluation at 270 nm. The method was linear in the range of 200-1000 ng/band for irbesartan and 200-600 ng/band for hydrochlorothiazide. The drug was subjected to different stress conditions (acid, base, oxidation, thermal, photolytic). All the degradation product were well resolved from the main drug. The proposed method is stability-indicating and suitable for routine analysis of fixed dose formulation in presence of degradation products.
J. Pharm. Biomed. Analysis 54, 445-450 (2011). An improved HPTLC method has been developed for simultaneous estimation of lamivudine (LVD), stavudine (STV), and nevirapine (NVP) in fixed dose formulation. HPTLC on silica gel with ethyl acetate - methanol - toluene - 25 % ammonia 12:6:12:1. The hRf value is 24 for LVD, 38 for STV and 69 for NVP. Densitometric evaluation at 254 nm. The method was linear in the range of 42-209 ng/band (LVD), 38-192 ng/band (STV) and 42-208 ng/band (NVP). The recovery values were in the range of 98.4-102.2 % for all three compounds. The method was found suitable for quality control of LVD, STV and NVP in fixed dose formulation.
Acta Chromatographica 20(4), 685-695 (2008). Determination of p-coumaric and protocatechuic acids in an ether fraction from a methanolic extract of Aquilegia vulgaris L. by HPTLC on silica gel with mixtures of heptane, dichloromethane, diisopropyl ether, formic acid, and water in various ratios. Satisfactory separation of the phenolic acids was achieved by use of the multiple gradient development technique. HPTLC results of the quantities of p-coumaric and protocatechuic acids were somewhat higher (0.396 and 2.584 mg/g dry plant material, respectively), than those determined by HPLC (0.374 and 2.283 mg/g dry plant material, respectively). Both methods were satisfactory in the precision, expressed as relative standard deviation, and are useful for quality control of Aquilegia vulgaris extracts.
62nd Indian Pharmaceutical Congress Abstract No. F-332 (2010). TLC of ramipril and hydrochlorothiazide on silica gel with ethyl acetate – methanol – chloroform – glacial acetic acid 11:3:7:2. The hRf values were 28 and 49 for ramipril and hydrochlorothiazide,respectively. Quantitative determination by absorbance measurement at 210 nm. The method was linear in the range of 500-1900 ng/band for both compounds. The recovery was 98-102 % for both drugs. The results were comparable when the sample was analysed by a dual wave-length method. The proposed method can be used for analysis of formulation without any interference from excipients.
62nd Indian Pharmaceutical Congress Abstract No. F-13 (2010). HPTLC of risperidone in bulk and pharmaceutical dosage form on silica gel with dichloromethane – methanol – ethanol – triethylamine 120:120:60:1. Quantitative determination by absorbance measurement at 280 nm. The linearity was obtained in the range 4-8 µg/spot (r2 =0.9989). The limit of detection and the limit of quantification for risperidone were 98 ng/zone and 599 ng/zone, respectively. The recovery was 99.5 %.
62nd Indian Pharmaceutical Congress Abstract No. F-343 (2010). TLC of hydrochlorothiazide (HCTZ) and irbesartan (IRBE) on silica gel with toluene – acetic acid – methanol 70:2:50. Quantitative determination by absorbance measurement at 264 nm. The hRf values were 15 for HCTZ and 45 for IRBE. The linearity was in the range of 90-540 ng/band and 180-900 ng/band with r2= 0.9989 for HCTZ and IRBE. The recovery of HCTZ was 95.3-97.7 % and of IRBE 95.2-98.7 %.
Acta Chromatographica 20(3), 497-511 (2008). HPTLC of 3-acetyl-11-keto-beta-boswellic acid (AKBA) on silica gel with toluene – ethyl acetate 7:3 at room temperature (25 ± 2 °C) in a twin-trough chamber with chamber saturation. Quantification of AKBA (hRf 52) by densitometry in absorbance mode at 250 nm. The linearity was in the range of 200–1200 ng/band (r=0.9989), recovery was 99.4-100.2 %, and the limits of detection and quantification were 3 and 9 ng/band, respectively. AKBA was subjected to various stress conditions: acid and alkali hydrolysis, oxidation, photodegradation, and dry and wet heat treatment. The degradation products were separated from the pure drug with significantly different hRf values.