Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      128 022
      Andrographis paniculata (Burm.f.) Nees: Traditional uses, phytochemistry, pharmacological properties and quality control/quality assurance
      S. KUMAR*, B. SINGH, V. BAJPAI (*Department of Chemistry, Ma. Kanshiram Government Degree College, Ninowa, Farrukhabad, 209602, India, sunilchem1986@gmail.com)

      J. Ethnopharmacol. 275, 114054 (2021). Review of methods and their conditions for quality control of herbal formulations derived from Andrographis paniculata by analytical techniques, including TLC and HPTLC. The document provided specific validation data for the analysis of andrographolide in different systems.

      Classification: 1b
      128 024
      Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species
      E. SACICI, E. YESILADA* (*Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, Atasehir 34755, Istanbul, Turkey, yesilada@yeditepe.edu.tr)

      Phytochem. Anal. 3093 (2021). HPTLC of hyperforin (1), hypericin (2) and hyperoside (3) in Hypericum species on silica gel with n-hexane - ethyl acetate 4:1 for (1), toluene - chloroform - ethyl acetate - formic acid 80:50:35:6 for (2) and ethyl acetate - formic acid - acetic acid - water 15:2:2:1 for (3). Detection by spraying with a derivatizing reagent (20 mL of sulfuric acid were carefully added to 120 mL methanol and diluted with 200 mL methanol), followed by heating. Quantitative determination by absorbance measurement at 366 nm. The hRF values of (1) to (3) were 49, 35 ad 49, respectively. Linearity was between 0.4 and 1.4 µg/zone for (1), 20 and 100 ng/zone for (2) and 10 and 100 ng /zone for (3). The intermediate precision was below 2 % (n=6) for (1) to (3). The LOD and LOQ were 120 and 400 ng/zone for (1), 6 and 20 ng/zone for (2) and 3 and 10 ng/zone for (3), respectively. Recovery was between 101.0 and 101.2 % for (1), 98.8 and 100.1 % for (2) and 100.4 and 101.4 % for (3).

      Classification: 7, 8a
      128 025
      Advances in the quality control of fenugreek seeds using chromatographic, spectroscopic and DNA-based techniques: A comprehensive review
      N. KANDIL, I. AYOUB, S. EL-AHMADY*, S. EL-MOGHAZY (*Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt, selahmady@pharma.asu.edu.eg)

      Phytochem. Anal. 3091 (2021). Comprehensive review of the application of chromatographic methods for the quality control of fenugreek seeds. The document described systems for the analysis of fenugreek, including the determination of trigonelline, 4-hydroxyisoleucine and diosgenin in seeds from different origins and in herbal formulations.

      Classification: 1b
      128 083
      Assessment of the greenness of new stability indicating micellar UPLC and HPTLC methods for determination of tenofovir alafenamide in dosage forms
      N.S. SAID, Z.A. NASR*, S.A. ABDEL-RAZEQ (*Pharm. Anal. Chem. Dep., Faculty of Pharmacy (Girls), Al-Azhar Univ., Cairo 11754, Egypt, zeinabadel@azhar.edu.eg; z.adel2210@gmail.com)

      J. of Chromatogr. Sci., 59 (10) 909-922 (2021). Development of a green stability indicating method for the quantitative determination of tenofovir alafenamide and its by-products produced under stress conditions. HPTLC on silica gel with n-butanol - acetic acid 7:3 and detection at 260 nm. Beer’ law was obeyed over the concentration range of 0.1- 4 μg/zone. Also micellar UPLC method. Both methods are validated according to ICH guidelines and successfully applied to the analysis of the drug in its tablets. In addition, their greenness was assessed using three different tools indicating their least hazardous effect on the environment.

      Classification: 32
      128 084
      (Development of a TLC method for identification of Dashanzha Tablets) (Chinese)
      L. LIU (Liu Lihui), H. CHANG (Changhua), Y. ZHOU (Zou Yanlin), X. ZHONG (Zhongxiaoqing), G. LU (Lugaorong), ZH. ZOU (Zou Zhun), J. ZOU (Zou Jieming)* (*Guilin Sanjin Pharm. Co., Ltd., Guilin 541004, China, zjm@sanjin.com.cn)

      Chinese J. Food & Drug 23 (5), 411-415 (2021). Dashanzha tablet is a Chinese patent medicine with the function of appetizing and digestion, used for food accumulation caused by loss of appetite, indigestion, abdominal distension. For quality control, TLC of the petroleum ether extracts on silica gel with cyclohexane - methylene dichloride - ethyl acetate - glacial acetic acid 200:50:80:1. Detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 ℃ until the zones are visible in daylight. Identification by fingerprint comparison with the standard ursolic acid and the standard ingredient drug undergone the same procedure in parallel. Satisfactory results were achieved by using plates from different manufactures and under varying temperature and humidity conditions.

      Classification: 32
      128 086
      Implementation of two chromatographic methods for simultaneous quantitation of thioctic acid, benfotiamine and cyanocobalamin
      S.S. ABBAS, A.M. BADAWEY, M.A. BAKR*, M.A. HEGAZY (*Pharm. Chem. Dep., Faculty of Pharm. Sci. & Pharm. Ind., Future Univ. in Egypt, 90th St., Fifth Settlement, New Cairo, Egypt, mariam.bakr@fue.edu.eg)

      J. Chromatogr. Sci., 59 (10), 964-970 (2021). Introduction of an accurate and sensitive method for the simultaneous determination of thioctic acid, benfotiamine and cyanocobalamin in bulk powders and in their pharmaceutical formulation. TLC on silica gel with methanol - chloroform - heptane-1 - o.4 % sulfonic acid sodium salt 70:30:1. Determination by densitometric evaluation at 240 nm. The hRf values were 17, 48 and 75 for cyanocobalamin, benfotiamine and thioctic acid, respectively.

      Classification: 32
      128 087
      (Study of a method for the identification of Huangjia Ruangan granules by multi-information thin-layer chromatography) (Chinese)
      ZH. WANG (Wang Zhongquan), CH. HUANG (Huang Chaoqing), ZH. HUANG (Huang Zhihui), J. GAO (Gao Jin), L. ZHANG (Zhang Lili), B. ZHANG (Zhang baoxian)*, L. TENG (Teng Lirong) (*Yingkerui (Hengqin) Pharm. Res. Inst. Co. Ltd. / New Drug Delivery Syst. Sub Center of national Res. Center for Modern Eng. & Technol. of Trad. Chinese Med., Eng. Technol. Res. Center of Guangdong Aerosol Inhal. Prep., Guangdong, Zhuhai 519000, China, zhangbaoxian@ykrskj.com)

      Chinese J. Ethnomed. & Ethnopharm. (10), 36-39 (2021). Huangjia Ruangan granules is a TCM preparation, which relaxes the liver and promotes blood circulation, and is used for treating liver fibrosis and early cirrhosis, spleen deficiency, liver depression and blood stasis. (A) Identification of Salvia miltiorrhiza Bge, Pueraria lobata (Willd.) Ohwi, and Paeoniae rubra root, by TLC of the methanol extracts, the control solutions lacking the three drugs, and the standards tanshinone IIA, puerarin, paeoniflorin, on silica gel first with chloroform – methanol – water 70:25:2.5 to 5 cm and then with toluene – ethyl acetate 24:1 to 8 cm; detection by spraying with 5 % vanillin in sulfuric acid – ethanol 1:200 and heating at 105 ˚C until the zones are visible in white light and UV 365 nm. (B) Identification of Astragali Radix, Panax notoginseng (Burkill) F. H. Chen ex C. H.) and Radix Bupleuri, by TLC of the methanol extracts, the control solutions lacking the three drugs and the standards astragaloside lV, notoginsenoside R1 and saikosaponin A, on silica gel with butanol – ethyl acetate – water 4:3:5 to 17 cm, detection by spraying with 2 % ethanol p-dimethylaminobenzaldehyde solution - sulfuric acid 2:3 and heating at 80 ˚C until the zones are visible, evaluation in white light and at UV 365 nm. The method was successfully applyed to identify six major ingredients in Huangjia Ruangan granules on the same plate through multi-information obtained, and proved to be simple, fast, specific, reproducible, robust and well suitable for the purpose.

      Classification: 32e
      128 090
      (Study of the method for the identification of Qixingcha Keli by thin-layer chromatography) (Chinese)
      CH. LIU (Liu Chunrong), J. LIU (Liu Jia), Y. WANG (Wang Yafang)*, Y. ZHOU (Zhou Yanfei), K. ZHONG (Zhong Kumrui), H. GONG (Gong Hao), Y. YANG (Yang Yanping) (*Bejing Veterinary Drug Monit. Inst., Bejing 102629 , China, wangyafang2002 @ aliyun.com)

      J. Trad. Chinese Veterinary Med. 55 (1), 15-19 (2021). Qixingcha Keli is a TCM preparation converted from human to animal use, for the treatment of gastric stagnation in piglets and other animals. Quality control of its component (A) Crataegus L. by TLC of the ethanol extracts, the control solutions with and without Crataegus L. on silica gel with ethyl ether - chloroform - formic acid 5:5:1 to 9 cm. Detection by heating the plates at 105 ˚C for 15 min, then spraying with 0.05 % bromophenol solution (pH = 7.5) and viewing in white light. For component (B) Glycyrrhiza uralensis Fisch., TLC of the ethanol extracts, the control solutions with or without Glycyrrhiza uralensis Fisch. on silica gel containing 1 % NaOH with ethyl acetate - formic acid - glacial acetic acid - water 15:1:1:1 to 18 cm, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 ˚C, evaluation in white light and at UV 365 nm. For (C) Uncaria rhynchophylla (Miq.) Miq. ex Havil., TLC of the ethanol extracts and the control solutions on silica gel with petroleum ether (60-90 ˚C) - propanone 3:2 to 9 cm, detection at UV 254 nm. For (D) Semen Coicis, by TLC of the ethyl acetate extracts and control solutions on silica gel with petroleum ether (60-90 ˚C) - ethyl ether - glacial acetic acid 166:34:1 to 9 cm, detection by spraying with 5 % vanillin in sulfuric acid - ethanol 1:200 and heating at 105 ˚C, detection in white light and at UV 365 nm.

      Classification: 32e
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