Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      103 171
      Direct enantiomeric TLC resolution of dl-penicillamine using (R)-mandelic acid and L-tartaric acid as chiral impregnating reagents and as chiral mobile phase additive
      R. BHUSHAN*, CH. AGARWAL (*Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India)

      Biomed. Chromatogr. 22 (11), 1237-1242 (2008). TLC of dl-penicillamine on silica gel 1) impregnated with L-tartaric acid; 2) impregnated with (R)-mandelic acid; and 3) with no impregnation but with chiral modifier added to the mobile phase. The mobile phases used were 1) acetonitrile - methanol - water 5:1:1; 3) ethyl acetate - methanol - water 3:1:1; and 2) acetonitrile - methanol - 0.5 % aqueous L-tartaric acid (pH 5) - glacial acetic acid 70:10:11:7. Detection by exposure to iodine vapors. The limit of detection of both was 120 ng/zone by use of L-tartaric acid (either by impregnation or added to mobile phase), and 110 ng/zone by use of (R)-mandelic acid. (R)-mandelic acid was found to be successful as a chiral impregnating reagent.

      Classification: 38
      104 039
      Evaluation of thin-layer chromatography systems for analysis of amino acids in complex mixtures
      J.D. VASTA, M. CICCHI, J. SHERMA*, B. FRIED (*Lafayette College, Department of Chemistry, Easton PA 18042-1782 USA)

      Acta Chromatographica 21 (1), 29-38 (2009). Evaluation of different TLC systems for analysis of 21 amino acids in biological tissues and fluids. Detection by derivatization with ninhydrin reagent, and determination of Rf values by slit-scanning densitometry. The five most suitable systems were cellulose and silica gel plates developed with either 2-butanol - pyridine - acetic acid - water 39:34:10:26 or 2-butanol - pyridine - 25 % ammonia - water 39:34:10:26, and ion exchange plates developed with citrate buffer of pH 3.3. Detection with ninhydrin allowed the identification of all amino acids except for leucine and isoleucine in complex mixtures. Quantification is possible as well if the amino acid of interest is well separated from adjacent components of the mixture. The method is illustrated with example chromatograms on cellulose HPTLC layer showing the identification and separation of amino acids in snail tissue samples.

      Classification: 18a
      104 086
      Free phenolic acids in Ruta graveolens L
      Halina EKIERT*, A. SZEWCZYK, A. KUS (*Jagiellonian University, Collegium Medicum, Faculty of Pharmacy, Chair and Department of Pharmaceutical Botany, 9 Medyczna Street, 30-688 Kraków, Poland; mfekiert@cyf-kr.edu.pl)

      in vitro culture. Pharmazie 64, 694-696 (2009). Preparative TLC and HPTLC of protocatechuic acid, vanillic acid, syringic acid, and p-coumaric acid and methanolic extracts on silica gel. Detection under UV light at 254 nm.

      Classification: 32e
      104 171
      Two dimensional thin layer chromatography (2D-TLC) for resolution of isomers of (±) bupropion HCl
      P. PATEL*, R. MASHRU (*Babaria Institute of Pharmacy, Vadodara, Gujarat, India)

      Abstract No. F-254, 61st IPC (2009). HPTLC of bupropion HCl on silica gel with quinine sulphate - methanol - water 13:20:12 in the first direction. Quinine sulphate was used as a chiral selector at a concentration of 3.5 mM. The two separated bands were detected under UV 366 nm. The hRf values of I (-) and d (+) isomers of bupropion HCl were 90 and 84, respectively. After the second run in the second dimension with methanol - water 80:13 they were better resolved with hRf values of 88 and 76.

      Classification: 32a
      104 239
      (Determination of related impurity substances in nisoldipine by thin-layer chromatography) (Chinese)
      Y. ZHOU (Zhou Ying)*, X. NIU (Niu Xiuhua) (*Nat.Inst. Cont. Pharm. & Biolog. Prod., Beijing 100050, China)

      Drug Standards of China 9 (2), 144-146 (2008). TLC of nisoldipine silica gel with chloroform - acetone - triethylamine - water 90:5:1. Detection under UV 254 nm. Semiquantification of impurities by comparison of spots. The method was successfully used for the quality control of real life samples.

      Classification: 32c
      105 039
      TLC separation of isomeric diazinodithiins and diazinyl sulfides as the Smiles rearrangement products
      K. PLUTA*, B. MORAK-MLODAWSKA, M. JELEN, R. KORLACKI (*Department of Organic Chemistry, The Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland; pluta@slam.katowice.pl)

      J. Liq. Chromatogr. Relat. Technol. 31, 3020-3031 (2008). TLC of twelf thioazines on silica gel with chloroform - ethanol 10:1 and chloroform, and on aluminum oxide with dichloromethane and benzene - chloroform 1:1 in a chamber saturated for 30 min. Detection under UV 254 and 366 nm. The retention parameters were measured and then calculated as separation factors deltaRf, RS, and alpha. The hRf values were correlated with the dipole moments of thioazines and the symmetry of diazinodithiins.

      Classification: 24
      105 124
      Micellar TLC of inorganic ions
      A. MOHAMMAD*, S. HENA, A. MOHEMAN (*Analytical Research Laboratory, Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh-202 002, India; alimohammad08@gmail.com)

      J. Planar Chromatogr. 23, 162-165 (2010). TLC of iron(III), copper(II), nickel(II), cobalt(II), cadmium(II), zinc(II), silver((I), lead(II), bismuth(III), mercury(II), titanium(IV), manganese(II), and chromium(VI) on silica gel with 0.02, 0.1, 0.2, and 1.0 M aqueous sodium dodecyl sulfate (SDS) (M1), 0.2 M SDS + 0.04 M tartaric acid (9:1, 1:1, and 1:9) (M2); 0.2 M SDS + 0.08 M tartaric acid (9:1, 1:1, and 1:9) (M3); 0.2 M SDS + 0.1M tartaric acid (9:1, 1:1, and 1:9) (M4); 0.2 M SDS + 0.08 M citric acid (1:1) (M5); 0.2 M SDS + 0.08 M formic acid(1:1) (M6); 0.2 M SDS + 0.08 M acetic acid (1:1) (M7); 0.2 M SDS + 0.08 M oxalic acid (1:1) (M8). Detection reagents used were: 0.5 % dithizone in carbon tetrachloride, 1.0 % aqueous potassium ferrocyanide, 1.0 % ethanolic dimethylglyoxim, 1:1 2.0 M aqueous sodium hydroxide in 30 % hydrogen peroxide, and a methanolic silver nitrate solution. Quantitative analysis of zinc(II) by spectrophotometry after extraction. The detection limits were 0.85, 0.05, and 1.5 µg respectively for lead(II), zinc(II), and cobalt(II). The in-situ detection of cations was more sensitive than detection in solution.

      Classification: 33a
      106 109
      A simplified method for rapid quantification of intracellular nucleoside triphosphates by one-dimensional thin-layer chromatography
      CH. JENDRESEN*, M. KILSTRUP, J. MARTINUSSEN (*Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark)

      Anal. Biochem. 409 (2), 249-259 (2011). Presentation of a less time-consuming, more sensitive, and more precise method for the quantitative determination of nucleoside triphosphates (NTPs), 5-ribosyl-1-pyrophosphate (PRPP), and inorganic pyrophosphate (PPi) in cell extracts by TLC: Separation of an acid extract of L. lactis by charcoal filtration into a filtrate and an eluate, which then was separated by TLC either in the Cashel solvent (0.85 M potassium phosphate, pH 3.4) or in the AFC solvent (3 M ammonium formate [pH 2.4] and 0.7 M ammonium chloride). Two-dimensional separation of 18 µL of the eluate sample using the AFC solvent in the first dimension and using 0.75 M LiCl in 7.5 % lithium borate (pH 6.8, borate solvent) in the second dimension.

      Classification: 21
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