Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      109 081
      Application of high-performance thin-layer chromatography for the simultaneous determination of lamivudine and tenofovir disoproxil fumarate in pharmaceutical dosage form
      P. CHANDRA, A. RATHORE, L. SATHIYANARAYANAN, K. MAHADIK* (*Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune 411038, Maharashtra, India, krmahadik@rediffmail.com)

      J. Chil. Chem. Soc. 56, 702-705 (2011). HPTLC of lamivudine (1) and tenofovir disoproxil fumarate (2) in bulk drug and pharmaceutical dosage form on silica gel with chloroform - methanol - toluene 4:1:1. Quantitative determination by absorbance measurement at 265 nm. The hRf values of (1) and (2) were 27 and 51, respectively. Linearity was between 60-210 ng/zone for both. LOD and LOQ were found to be 20 and 40 ng/zone for (1) and 30 and 60 ng for (2). The intermediate/interday/intra-day precision was 0.6 % (n=6). Recovery (by standard addition) for (1) and (2) was between 98-102 %. The HPTLC method is suitable for routine analysis of lamivudine and tenofovir in pharmaceutical dosage form.

      Classification: 32a
      109 099
      Densitometric HPTLC method for simultaneous quantification of sennosides A and B and gallic acid in a pharmaceutical dosage form
      S.A. NAVALE, V.V. KUBER, S.G. BHOPE* (*Tulip Lab Pvt. Ltd, F-20/21, MIDC Ranjangaon, Pune-412220, India; bshrinivas16@gmail.com)

      J. Planar Chromatogr. 24, 72-76 (2011). HPTLC of sennoside A and B and gallic acid on silica gel with toluene - ethy acetate - formic acid - methanol 8:8:4:5. Quantitative analysis by densitometry at 270 nm. Linearity was between 114-427 ng/zone for sennosides A and B and 100-375 ng/zone for gallic acid. For sennosides A and B and gallic acid, hRf values were 26, 21 and 80, correlation coefficients were 0.95, 0.998, and 0.997, method precisions (%RSD, n = 6) were 1.1, 1.1 and 0.9 %, recoveries were 96.3-97.2 %, 98.1-100.8 % and 97.1-98.1 %, respectively. LOD andLOQ was 30 and 25 ng/zone for sennoside A, 20 and 99 ng/zone for sennoside B, and 66 and 82 ng/zone for gallic acid.

      Classification: 32e
      109 122
      Simultaneus densitometric determination of ivermectin and albendazole by high-performance thin-layer chromatography
      S.J. VARGHESE*, P. VASANTHI, T.K. RAVI (*Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641044, Tamil Nadu, India; susheeljvqyahoo. com)

      J. Planar Chromatogr. 24, 344-347 (2011). HPTLC of ivermectin (IVM) and albendazole (ALB) on silica gel with toluene - ethyl acetate - glacial acetic acid 12:8:1 in a twin-trough chamber saturated for 30 min. Quantitative determination by densitometry in absorbance mode at 247 nm. Linearity was between 0.12 and 0.54 µg/band for IVM and 8 and 36 µg/band for ALB. The recovery was between 98-101 % for IVM and ALB. The hRf value was 39 for IVM and 62 for ALB. LOD and LOQ were 0.02 and 0.09 µg/band for IVM and 0.08 and 0.1 µg/band for ALB. The intra-day and inter-day precision (n = 6) was 0.6 % and 1.1 % for IVM and 0.6 % and 1.2 % for ALB, respectively. Recovery (by standard addition) ranged from 98-101 % for both compounds.

      Classification: 32a
      110 157
      (Study of the factors influencing on the degradation of stachydrine in Yimucao ointment during its storage) (Chinese)
      Y. WANG (Wang Yu), M. GUO (Guo Maofeng), Y. XU (Xu YaN), K. QIN (Qin Kunmig) B. CAI (Cai Baochang)* (*Res. Center of Nat. Min. of Educ. for the Proj. of TCM Proc. Normal., Nanjing Univ. of TCM, Nanjing 210061, China)

      J. of Global Trad. Chinese Med. 5 (5), 362-363 (2012). Yimucao ointment is a TCM preparation for curing irregular menstruation and postpartum blood stasis. It was found recently that degradation of stachydrine, the active component in the medicine appeared during its storage. In order to improve the quality control of the medicine the stability and influencing factors during its storage have been investigated. TLC on silica gel with n-butanol – ethyl acetate – hydrochloric acid 8:1:3, detection by heating at 105 °C for 15 min firstly and then spraying with 1 % ferric chloride in ethanol – 5 % potassium iodobismuthate solution 1:10 until the zones were visible in daylight. Quantitative determination of stachydrine by densitometry at 510 nm. Investigation of the influence of temperature and light on the content of stachydrine in Yimucao ointment showed that light is the primary reason causing degradation during its storage.

      Classification: 32e
      111 098
      (Study of the method for the quality control of Yangning capsules) (Chinese)
      ZH. LI (Li Zhiyong)*, D. SUN (Sun Dongmei), L. WANG (Wang Luolin) (*Guangdong Provinc. Inst. of Trad. Chinese Med., Guangdong, Guangzhou 510095, China)

      Chinese J. of Lishizhen Trad. Med. & Pharm. 22 (1), 100-101 (2011). Yangning capsules are a herbal TCM for treating skin pruritus caused by various reasons. For quality control, TLC on silica gel 1) for Radix Saposhnikoviae and Radix Angelicae Sinensis, with petroleum ether (60-90 °C) – ethyl acetate 4:1, detection under UV 366 nm; 2) for Radix Glycyrrhizae, with ethyl acetate – formic acid – glacial acetic acid 15:1:1:2, detection by spraying with 10 % sulfuric acid in ethanol and heating at 105 °C, viewing under UV 366 nm; 3) for Cortex Dictamni, with toluene ethyl acetate – formic acid 25:15:1, detection by spraying with 5 % vanillin in sulfuric acid – ethanol 1:4 and heating at 105 °C, viewing in daylight. Quantification of matrine and oxymatrine by HPLC.

      Classification: 32e
      112 135
      A new high-performance thin layer chromatography-based assay of detergents and surfactants commonly used in membrane protein studies
      Laurie-Anne BARRET, Ange POLIDORI, Francoise BONNETÉ, P. BERNARD-SAVARY, Colette JUNGAS* (*CEA, IBEB, Lab Bioenerget Cellulaire, Saint-Paul-lez-Durance, 13108, France)

      J. of Chromatogr. A 1281, 135-141 (2013). The use of detergents for the extraction, solubilization and purification of membrane proteins (MPs) is necessary due to their hydrophobic nature. Detergent quantification is essential to routine analysis because the concentration of amphiphiles is crucial in the crystallization process. HPTLC of detergents (in small quantities, bound to solubilized MPs) on silica gel with dichloromethane – methanol – acetic acid 80:19:1. The optimum HPTLC conditions were investigated using n-dodecyl-beta-D-maltoside (DDM), the most popular detergent for membrane protein crystallization. Quantification by fluorescence measurement at 366 nm using a Hg lamp. The calibration curve was linear in the range of 100-1600 ng of DDM in water and the limit of detection of was 50 ng/zone, which is the best LOD achieved to date for a routine detergent assay (not modified by the addition of NaCl, commonly used in protein buffers). In comparison with other techniques (colorimetry, GC, and FTIR) the HPTLC method has the advantage of no prior sample treatment for concentration or extraction, and no chemical labeling is required. In comparison with TLC, the HPTLC method is 100 times more sensitive. The HPTLC method is suitable for routine analysis, assay results are obtained within 3 hours and only few microliters of sample are needed.

      Classification: 19, 35a
      113 038
      Development of a validated stability-indicating high-performance thin-layer chromatographic method for the quantification of levetiracetam
      P. BHATTACHARYA, M. GHOSH, A. CHATTERJEE, S. BANGAL, A. SAHA* (*Department of Chemical Technology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata 700 009, India, achintya_saha@yahoo.com)

      J. Planar Chromatogr. 27, 132-139 (2014). HPTLC of levetiracetam on silica gel with toluene - ethyl acetate - methanol 2:1:1. Quantitative determination by absorbance measurement at 204 nm. The hRF value for levetiracetam was 50. Linearity was in the range of 1-1000 ng/zone. The intermediate/interday/intra-day precisions were below 1 % (n=6). The LOD and LOQ were 30 and 100 ng/zone, respectively. Recovery was between 99.2 and 100.9 %.

      Classification: 17c
      113 084
      Use of a model procedure for transfer of Minilab qualitative screening TLC methods for lumefantrine and artemether in a combined tablet formulation to individual and simultaneous quantitative HPTLC-densitometry methods
      M. NGUYEN, J. SHERMA* (* Department of Chemistry, Lafayette College, Easton, PA 18042, USA)

      Trends in Chromatography 8, 131-135 (2013). Based on the Minilab TLC screening methods two individual and one simultaneous HPTLC methods for quantification of lumefantrine and artemether were developed. HPTLC of artemether, lumefantrine, and both substances in a combined tablet formulation on silica gel with ethyl acetate - glacial acetic acid - toluene 2:1:9 with chamber saturation. Quantitative absorbance measurement of lumefantrine at 254 nm. For artemether, detection by spraying with methanol - 96 % sulfuric acid 19:1 and heating at 100 °C for 5 minutes, evaluation in daylight and quantitative absorbance measurement at 610 nm. With the simultaneous method artemether zones were detected by heating at 160 °C for 5 min, and after cooling absorbance measurement at 254 nm was performed. This is a novel, reagent-free detection method based on thermochemical activation of fluorescence quenching. Precision (%RSD) for the artemether individual method was 0.1-0.6 % and recovery 98-103 %. Precision (%RSD) for the lumefantrine individual method was 0.9-1.8 % and recovery 100-102 %. With the simultaneous method the hRF was 34 for lumefantrine and 61 for artemether, precision (%RSD) was below 3 % and recovery was 98-100 %.

      Classification: 32a
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