Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
  • Keyword register: select an initial character and browse associated keywords
  • Search by CBS edition: Select a CBS edition and find all related publications

Registered users can create a tailor made PDF of selected articles throughout CCBS search – simply use the cart icon on the right hand of each abstract to create your individual selection of abstracts. You can export your saved items to PDF by clicking the download icon.

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      101 027
      HPTLC method for determination of colchicine in a pharmaceutical formulation
      V. MIRAKOR, V. VAIDYA*, S. MENON, P. CHAMPANERKER, A. LAUD (*Therapeutic Drug Monitoring Laboratory, 194, Scheme No. 6, Road No. 15, Sion Koliwada, Sion (East), Mumbai 400-022, India; tdmlab@vsnl.net, vaidya_vikas@yahoo.com)

      J. Planar Chromatogr. 21, 187-189 (2008). HPTLC of colchicine on silica gel with ethyl acetate - acetonitrile - water - formic acid 16:2:1:1 in a twin-trough chamber saturated for 10 min. Quantitation by densitometry at 358 nm.

      Classification: 22
      101 056
      Simultaneous HPTLC determination of escitalopram oxalate and clonazepam in combined tablets
      N. DHAVALE*, S. GANDHI, S. SABNIS, K. BOTHARA (*Department of Pharmaceutical Analysis, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O, Pune, 411001, India)

      Chromatographia 67 (5-6), 487-490 (2008). Simultaneous determination of escitalopram oxalate and clonazepam in a combined tablet dosage form by HPTLC on silica gel aluminum plates with toluene - ethyl acetate - triethylamine 14:7:6. Quantification by densitometry at 258 nm.

      Classification: 32c
      101 086
      Development and validation of a simultaneous HPTLC method for the estimation of olmesartan medoxomil and hydrochlorothiazide in tablet dosage form
      N.J. SHAH*, B.N. SUHAGIA, R.R. SHAH, N.M. PATEL (*Shri B. M. Shah College of Pharmaceutical Education and Research, Modaso 383315, India)

      Ind. J. Pharm. Sci. 69 (6), 834-836 (2007). HPTLC of olmesartan medoxomil and hydrochlorothiazide simultaneously in combined dosage forms on silica gel with acetonitrile - chloroform - acetic acid 14:4:1. Detection at 254 nm. Linearity was between 500 and 750 ng/spot for olmesartan medoxomil and 100 and 600 ng/spot for hydrochlorothiazide. The limit of detection and the limit of quantification for olmesartan medoxomil was 170 and 500 ng/spot respectively, and for hydrochlorothiazide 30 and 100 ng/spot, respectively. The proposed method can be used to determine the drug content of marketed tablet formulation.

      Classification: 32a
      102 019
      A simple method for the quantification of urethane in spirits
      E. JARYJ, K. LORENZ, B. SPANGENBERG* (*University of Offenburg, Institute of Process Engineering, Badstrasse 24, 77652 Offenburg, Germany; spangenberg@fh-offenburg.de)

      J. Liq. Chromatogr. Relat. Technol. 31, 1969-1976 (2008). TLC of urethane on spherical silica gel with methyl-t-butyl ether - methanol 7:3. Detection by immersion in a solution of 80 µL cinnamaldehyde in 40 mL acetone with 2.4 mL phosphoric acid followed by heating in an oven at 130 °C for 10 min. The fluorescence can be enhanced by the factor of 2 if the plate is dipped for 4 s into a solution of 10 % polyethylene glycol 600 in methanol. Quantitative determination by absorbance measurement in the range of 445 to 460 nm.

      Classification: 11a
      102 039
      Improved detection of ergosterol, stigmasterol, and selected steroids on silica coated TLC plates using phosphomolybdic acid staining
      P.K. ZARZYCKI*, M. BARAN, E. WLODARCZYK, M. A. BARTOSZUK (*Laboratory of Toxicology, Department of Environmental Biology, Koszalin University of Technology, Sniadeckich 2, 75-453 Koszalin, Poland; pkzarz@wp.pl or pawel_k_z@hotmail.com)

      J. Liq. Chromatogr. Relat. Technol. 30, 2629-2634 (2007). TLC of ergosterol, stigmasterol, dihydrocholesterol, 4-cholesten-3-one, cholecalciferol, and cholesterol acetate on silica gel using methanol - dichloromethane 1:19 in a saturated horizontal chamber. Detection by spraying twice with 10 % phosphomolybdic acid in methanol and heating. Contrary to the data reported in literature, the experiments revealed that the best conditions for robust detection of these analytes are achieved if the TLC plates are heated at relatively low temperatures (between 40 and 80 °C) and for longer times (more than 20 min).

      Keywords: densitometry
      Classification: 13c
      102 062
      Identification and quantification of amino acids in peptides
      Roseline SBAFFO-POASEVARA (API Analytical Development, IPSEN, 5 avenue du Canada, 91966 Les Ulis, France, roseline.poasevara@ipsen.com)

      CBS 101, 2-4 (2008). HPTLC of amino acids (from hydrolysis of peptides) on silica gel, Diol phase, and cellulose with either 2-butanol - acetic acid - pyridine - water 15:3:10:12 or 2-butanol - 25 % ammonia - pyridine - water 39:10:34:26 in a twin-trough chamber or horizontal chamber. Detection by dipping in ninhydrin solution (0.5 % in 2-propanol) followed by heating at 110 °C for 5 min. Better results are achieved by adding ninhydrin directly to the mobile phase at a 0.5 %-level. Quantitative determination by absorbance measurement at 440 nm. Selectivity was better on the cellulose and silica gel plate. Selection of the chromatographic system depended on which amino acids had to be separated and no general recommendation could be given. HPTLC analysis of a hydrolyzed peptide sample (containing Phe, Trp, D-Bal, Apc and Inp) on cellulose with the acidic mobile phase. All five amino acids were quantified between 70 and 130 % of the theoretical value for non-stable amino acids (degradation 5 to 30 %).

      Classification: 18a
      102 091
      Rapid high-performance thin-layer chromatographic method for detection of 5 % adulteration of black cohosh with Cimicifuga foetida, C
      Anita ANKLI*, E. REICH, M. STEINER (*CAMAG Laboratory, Sonnenmattstr. 11, 4132 Muttenz, Switzerland; anita.ankli@camag.com)

      heracleifolia, C. dahurica, or C. americana. J. AOAC Int. 91, 1257-1264 (2008). HPTLC of black cohosh extracts and references cimifugin, 23-epi-26-deoxyactein, actein on silica gel with toluene - ethyl formate - formic acid 5:3:2 in a twin-trough chamber saturated for 20 min. HPTLC plates were conditioned to 5 % relative humidity or less. For identification of species derivatization by dipping for 1 s in sulfuric acid reagent (10 % in methanol) followed by heating at 100 °C for 5 min and evaluation under white light and UV 366 nm. For detection of adulteration with Cimicifuga foetida derivatization with boric acid/oxalic acid reagent, for detection of adulteration with C. heracleifolia and C. dahurica derivatization with antimony(III) chloride reagent. Evaluation under UV 254 nm and after derivatization under UV 366 nm and white light. The method allows visual detection of 5 % of these adulterants in Cimicifuga racemosa.

      Classification: 32e
      102 108
      SIMULTANEOUS ESTIMATION OF ACECLOFENAC AND PARACETAMOL BY HPTLC IN PURE AND PHARMACEUTICAL DOSAGE FORM
      N. Harikrishnan*, V. Gunasekaran, A. Sathishbabu, G. Rao (*Dept. of Pharmaceutical Analysis, Vel’s College of Pharmacy, Old Pallavaram, Chennai 600117, India, harry74velscollege@yahoo.co.in)

      Asian J. Chem. 19(5), 3918-3922 (2007). TLC of paracetamol and aceclofenac on silica gel with toluene - isopropyl alcohol - ammonia 20:20:3. Quantitative determination by absorbance measurement at 254 nm. Linearity was between 60 and 140 µg/mL for aceclofenac and 460 and 540 µg/mL for paracetamol. Recovery (by standard addition method) of paracetamol and aceclofenac was between 98.6 and 99.3 %. The proposed method was found to be accurate, precise, simple and rapid could be used for routine analysis.

      Classification: 32a
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