Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      95 020
      Quantitative analysis of flavonoids and phenolic acids by two-dimensional thin layer chromatography
      Marica MEDIC-SARIC*, I. JASPRICA, A. MORNAR, A. SMOLCIC-BUBALO, P. GOLJA (*Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovacica 1, 10000 Zagreb, Croatia)

      J. Planar Chromatogr. 17, 459-463 (2004). TLC of standard solutions of nine flavonoids and six phenolic acids (cinnamic, o-coumaric, m-coumaric, p-coumaric, caffeic, ferulic acid, galangin, quercetin, pinocembrin, naringenin, apigenin, chrysin, kaempferol, morin, acacetin) on silica gel in pre-saturated developing chambers with 1) n-hexane - ethyl acetate - glacial acetic acid 31:14:5, or 2) chloroform - methanol - formic acid 88:7:5. After drying, bands were visualized under short- and long-wavelenghth UV light. Detection by spraying with 1 % aluminium trichloride solution and evaluation under long-wavelength UV light. Standards were chromatographed again with a propolis extract. First, plates were developed with mobile phase 1 (or 2), the eluent was evaporated, standard solutions were applied again, and the plate was rotated through 90 ° and chromatographed again with mobile phase 2 (or 1). The presence (or absence) of all standards was determined according to their Rf values and fluorescence colors. Quantitative determination by absorbance measurement at 254 and 366 nm.

      Classification: 8a
      95 048
      Validation and application of an HPTLC method for the determination of parthenolide in feverfew herbal products
      E. A. ABOURASHED (Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh Saudi Arabia 11451)

      J. Planar Chromatogr. 17, 375-378 (2004). HPTLC of parthenolide and extracts of feverfew capsules on silica gel with ethyl acetate - n-hexane 3:2 in glass chambers presaturated for 30 min. Detection by dipping in p-anisaldehyde reagent and heating at 105 °C for 5 min, followed by immediate densitometric scanning at 543 nm. The method is precise with CV < 5%; calibration recovery of 101.12 +/- 4.11 % and overall accuracy of 101.14 +/- 4.47 %. The levels of parthenolide in the products analyzed ranged from 0.03 to 0.24 %.

      Classification:
      95 066
      TLC analysis of non-steroidal anti-inflammatory drugs and videodensitometric determination of fenbufen in tablets
      H. HOPKALA, A. POMYKALSKI* (*Department of Medicinal Chemistry, Faculty of Pharmacy, Prof. Skubiszewski Medical Universit y of Lublin, 6 Chodzki St., 20-093 Lublin, Poland)

      J. Planar Chromatogr. 17, 383-387 (2004). TLC of fenbufen, ibuprofen, ketoprofen, diclofenac sodium, mefenamic acid, and tiaprofenic acid on silica gel by ascending and horizontal techniques, and on RP-18 in horizontal chambers. Good separation was achieved on silica gel by horizontal development with chloroform - methanol - 25 % ammonia 67:25:8; reversed phase chromatography on RP-18 with 0.15 mol/L phosphate buffer, pH 5.73 - 10 % CTMA-Br (N-cetyl-N,N,N-trimethylammonium bromide) in methanol 7:13 enabled better separation of the six drugs. Detection under UV light at 254 nm - for ibuprofen detection was best achieved after normal phase chromatography with 20 % aqueous sodium carbonate solution. A simple videodensitometric procedure was developed and validated. RSD for quantitation of fenbufen was 2.44 - 3.10 %.

      Classification: 32a
      95 087
      HPTLC method for the estimation and quantification of gallic acid in some ayurvedic formulations of triphala
      Sapna SHRIKUMAR*, S. CICY, M. SUKUMAR, T. K. RAVI (*Department of Pharmaceutical Analysis, College of Pharmacy, SRIPMS, Coimbatore 641 044, India)

      IPC 56th 2004, Abstract No. GP-26. HPTLC of triphala, an ayurvedic formulation containing about 3.60 % of total phenolics. Separation of alcoholic triphala extracts on silica gel with n-hexane - ethyl acetate 2:1. Rf value of the main spot gallic acid was 0.04 in triphala and its formulation. The method was found to be very specific for gallic acid having a linearity range of 0.2 - 1.6 mg/mL. Several formulations analyzed by HPTLC contained 5.2 - 7.6 % of gallic acid. The reported method is suitable for estimation of gallic acid in raw material and formulations.

      Classification: 32a
      96 004
      Application of thin-layer chromatographic data in quantitative structure-activity relationship assay of thiazole and benzothiazole derivatives with H1-antihistamine activity
      Elzbieta BRZEZINSKA*, Grazyna KOSKA, Alicja KLIMCZAK (*Department of Analytical Chemistry, Medical University of Lódz, Muszy skiego 1, 90-151, Lódz, Poland)

      Part II. J. Chromatogr. A 1007 (1-2), 157-164 (2003). Quantitative structure–activity relationship (QSAR) analysis of H1-antihistamine activity was carried out and chromatographic data of 2-[2-(phenylamino)thiazol-4-yl]ethanamine, 2-(2-benzyl-4-thiazolyl)ethanamine, 2-(2-benzhydrylthiazol-4-yl)ethylamine derivative, and 2-(1-piperazinyl- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives were obtained. Silica gel impregnated with solutions of selected amino acid mixtures (-Asp, Asn, -Thr and -Lys) were used in two developing solvents as human histamine H1-receptor (hH1R) antagonistic interaction models. Lipophilicity data of the examined compounds were obtained and used in the QSAR assay. Using regression analysis, relationships between chromatographic and biological activity data were found. The correlations obtained in the present experiment with NP-TLC are more significant that those obtained in the experiment with RP2-TLC because of the optimal fitting of the chromatographic system conditions to the lipophilicity of solutes. All proposed chromatographic models should facilitate pre-selection of the new drug candidates. The correlations of calculated pA2(H1) values of the tested compounds predicted by the use of the best equations versus their pA2(H1) obtained from the biological tests were significant (R2= 0.91-0.94).

      Classification: 2c
      96 046
      HPTLC method for the determination of acteoside in ribwort plantain (Plantago lanceolata L
      A. Umek, A. Rupert, A. Mlinaric, J. Kac* (*Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia)

      J. Planar Chromatogr. 18, 147-150 (2005). HPTLC of acteoside from leaves of Plantago lanceolata on silica gel with ethyl acetate - formic acid - water 18:1:1. Quantitative determination by densitometry at 334 nm. Intra-day and inter-day RSD were 0.58 and 2.0 %, respectively. Instrumental precision and repeatability of the method (CV) were found to be 0.62 and 1.5 %, respectively. The average recovery was 102.3 %.

      Classification: 14
      96 076
      Estimation of etoricoxib in tablets by HPTLC
      Ratna AWATE*, V. DHAINJE, DR. VAISHALI SHIRSAT (*Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai 400098, India)

      Abstract G-35, IPC (2005). HPTLC of etoricoxib in tablets on silica gel with n-hexane - ethyl acetate 1:3. Quantitative determination by absorbance measurement at 237 nm. The method was linear within the range of 100-500 ng/spot with a recovery rate of 97.4 %. LOD was 40 ng/spot and LOQ 100 ng/spot.

      Classification: 32a
      96 102
      Simultaneous estimation of pantoprazole and mosapride in their pharmaceutical preparations by HPTLC
      R. KAKDE*, V. KACHROO, P. INGALKAR (*Department of Pharmaceutical Sciences, Nagpur Univ., Nagpur 440 010, Maharashtra, India)

      Abstract G-9, IPC (2005). HPTLC of pantoprazole and mosapride in combined dosage form on silica gel with methanol - toluene - chloroform 4:30:15. Quantitative determination by absorbance measurement at 305 nm. The hRf value of pantoprazole was 31 and of mosapride 43, recovery was 99.9-101.1 %. Accuracy, precision, and linearity of the method were established.

      Classification: 32a
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