Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      107 046
      Formulation, HPTLC method development and validation of gallic acid in health drinks
      S. BOHARUPI*, A. TATED, F. KHAN, A. CHANDEWAR (*Dept. of Pharmaceutical Chemistry, P. Wadhwani College of Pharmacy, Yavatmal 445001, India)

      62nd Indian Pharmaceutical Congress Abstract No. F-259 (2010). Health drinks usually contain several phytopharmaceuticals with immunomodulatory and antioxidant activities. TLC of gallic acid on silica gel with toluene – ethyl acetate – methanol – formic acid 15:15:1:4. The gallic acid content was established and the identity of the gallic acid zone in sample and standard was confirmed by UV spectra comparison.

      Classification: 11a
      107 067
      Thin-layer chromatographic method for the determination of ternary mixture containing salbutamol sulphate, bromhexine hydrochloride and etofylline
      H. DAVE*, Rajeshree MASHRU, A. PATEL (*Centre of Relevance and Excellence in Novel Drug Delivery Systems, Pharmacy Dept., G. H. Patel Bldg., Dono’s Plaza, The M. S. University, Baroda, Fatehgung, Vadodara, Gujarat, India 390002, India, rajshreemashru_msu@yahoo.com)

      J. Pharm. Sci. & Res. 2(2), 143-148 (2010). TLC of salbutamol sulphate (SS), bromhexine hydrochloride (BH), and etofylline (ET) in fixed dose formulation on hand-made silica gel plates with methanol – n-hexane 2:1. All three compounds were well separated with hRf values of 25 for SS, 71 for ET and 91 for BH. Detection at 254 nm as well as by exposure to iodine vapors. For spectophotometric quantification the bands of the selected drug in sample and standard mixture were scraped off, suspended in methanol, and the absorbance was measured at the maximum absorbance wavelength of each compound.

      Classification: 17a
      107 086
      Simultaneous estimation of risperidone and trihexyphenidyl hydrochloride in tablets by HPTLC
      Kranti MALPURI*, S. YAMUNA, R. VIJAYAGEETHA, Shantha ARCOT (*Final year B. Pharmacy, Faculty C. L. Baid Matha College of Pharmacy Chennai, India)

      62nd Indian Pharmaceutical Congress Abstract No. F-249 (2010). TLC of risperidone and trihexyphenidyl hydrochloride on silica gel with methanol – chloroform – glacial acetic acid 160:40:0.1. Quantitative determination by absorbance measurement at 254 nm. The linearity was in the range of 20-60 µg/band and 10-30 µg/band for risperidone and trihexyphenidyl hydrochloride, respectively. The recovery was 99.4-99.9 % for both drugs.

      Classification: 23e
      107 103
      Specific separation of thiamine from hydrophilic vitamins with aqueous dioxane on precoated silica TLC plates
      A. MOHAMMAD*, A. ZEHRA (*Aligarh Muslim University Analytical Research Laboratory, Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh, India)

      Acta Chromatographica 20(4), 637-642 (2008). Specific separation of thiamine hydrochloride from riboflavin, nicotinic acid, calcium D-pantothenate, pyridoxine hydrochloride, cyanocobalamin, and ascorbic acid by TLC on silica gel with dioxane – water 1:1. Detection under UV light. Examination of the effect of impurities (metal cations and inorganic anions) on the chromatography of thiamine hydrochloride. The detection limit for thiamine hydrochloride was 0.09 µg/zone and the relative standard deviation of the hRf value of thiamine hydrochloride in five analyses was 14.9 %.

      Classification: 27
      107 121
      Development and validation of a densitometric TLC method for analysis of trigonelline and 4-hydroxyisoleucine in Fenugreek seeds
      C.L. GOPU*, S.S. GILDA, A.R. PARADKAR, K.R. MAHADIK (*Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India)

      Acta Chromatographica 20(4), 709-719 (2008). HPTLC of trigonelline and 4-hydroxyisoleucine from Fenugreek seeds (Trigonella foenum-graceum) on silica gel with n–butanol – methanol – acetic acid – water 8:3:2:2. Detection by spraying with ninhydrin reagent. Quantification by densitometry at 266 nm for trigonelline, and at 395 nm for 4-hydroxyisoleucine. The linearity was in the range of 100-1000 ng/band for trigonelline and 50-500 ng/band for 4-hydroxyisoleucine, respectively, with r=0.9992 and 0.9986 respectively. The average recovery at three different levels was 99.4 % for trigonelline and 99.1 % for 4-hydroxyisoleucine.

      Classification: 32c
      107 138
      Development and validation of an HPTLC method for analysis of zerumbone, the anticancer marker from Zingiber zerumbet
      K.K. ROUT*, S.K. MISHRA, J. SHERMA (*Utkal Univ. Pharm. & Phytochem. Div., Univ. Dep. of Pharm. Sci., Bhubaneswar 751004 Orissa, India)

      Acta Chromatographica 21(3), 443-452 (2009). HPTLC on silica gel with ethyl acetate – hexane 3:17. Detection and quantification by densitometry at the maximum absorbance wavelength of 250 nm. The linearity was in the range of 60–260 ng/zone with r=0.9997. The limits of detection and quantification were 20 and 60 ng/zone, respectively. The precision and repeatability of the method were found to be 0.8 and 1.1 %, respectively. Recovery ranged from 97.9-100.1 %. The maximum zerumbone content in the rhizome was 1.81 %.

      Classification: 32e
      107 157
      How to suppress the spontaneous oscillatory in-vitro chiral conversion of a-substituted propionic acids? A thin-layer chromatographic, polarimetric, and circular dichroism study of complexation of the Cu(II) cation with L-lactic acid
      M. SAJEWICZ*, E. JOHN, D. KRONENBACH, M. GONTARSKA, M. WRÓBEL, T. KOWALSKA (*Silesian University, Inst. of Chem., 9 Szkolna Street, 40-006 Katowice, Poland)

      Acta Chromatographica 21(1), (2009) . This study focused on the attempt to suppress the spontaneous oscillatory in-vitro chiral conversion of a-substituted propionic acids using, as example, L-lactic acid dissolved in water in the presence of copper(II) cations to check whether the coordinate covalent bonds between copper(II) and L-lactic acid ligands prevented the latter species from oscillatory chiral conversion. Aqueous solutions of copper(II) acetate and lactic acid in the molar ratios 1:1, 1:2, and 1:3 were stored and the possible chiral conversion of L-lactic acid was monitored by TLC, polarimetry, and circular dichroism spectroscopy. It was found that chelating of copper(II)cations with L-lactic acid did not result in suppression of the spontaneous oscillatory in-vitro chiral conversion of the acid from the TLC data. Different molar proportions of copper(II) cation and L-lactic acid had somewhat different effects on the dynamics of conversion, in contrast, when L-lactic acid is dissolved in water in the presence of copper(II)cations almost no chiral conversion is observed from polarimetric and circular dichroism studies. It was therefore concluded that chelating of copper(II) cations with L-lactic acid stabilizes the chiral structure of the acid in solution. The structure-stabilizing effect of copper(II) cations is weakened by the TLC system due to the interaction of the copper(II)-L-lactic acid complex with the silica gel.

      Classification: 38
      108 027
      Development and validation of a normal-phase HPTLC-densitometric method for the quantitative analysis of fluconazole in tablets
      D.H. SHEWIYO, E. KAALE, P. G. RISHA, H. B. SILLO, B. DEJAEGHER, J. SMEYERS-VERBEKE, Y. VANDER HEYDEN* (*Analytical Chemistry and Pharmaceutical Technology, Center for Pharmaceutical Research, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; yvanvdh@vub.ac.be)

      J. Planar Chromatogr. 24, 529-533 (2011). HPTLC of fluconazole (2-(2-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-2-propanol) on silica gel with ethyl acetate - methanol - ammonia - diaminoethane 170:20:10:1. Quantitative determination by densitometry at 216 nm. The hRf value was 40. The %RSD for repeatability and intermediate precision were 1.6 and 3.1 %, respectively. The mean recovery was 99.1 %.

      Classification: 6
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