Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      100 175
      Analysis of ropinirole in tablet dosage form
      J.V. SUSHEEL*, S. MALATHI, T.K. RAVI (*DeparTment of Pharmaceutical Analysis, College of Pharmacy, SRIPS, Coimbatore, Tamil Nadu, India)

      Indian J. Pharm. Sci. 69(4), 589 (2007). HPTLC of ropinirole on silica gel with methanol - acetone 4:1. Aripiprazole was used as internal standard. Under chromatographic conditions both ropinirole and aripiprazole were well separated. Evaluation under UV 254 nm. UV spectrometry was carried out at 250 nm.

      Classification: 32a
      101 020
      Spray reagents for the visualization and detection of sesame oil unsaponifiables on thin-layer chromatograms
      A.R. ADEGBOLA*, E.O. DARE, A.A. LASISI (*Department of Chemistry, University of Agriculture, P. O. Box 28, UNAAB post office, Abeokuta, Nigeria)

      Chromatographia 68 (1-2), 151-153 (2008). Anisaldehyde and crotonaldehyde reagent are suitable as spray reagents for the detection of major components of sesame oil unsaponifiables. Derivatization with anisaldehyde reagent lead to chromatograms with coloured zones characteristic for lignans and sterols in Sesamum indicum. By derivatization with crotonaldehyde four of the eleven unsaponifiable matters could be detected as more stable and brightl coloured zones. The results obtained could serve as a guide in the monitoring of oil’s stability, adulteration and contaminations.

      Classification: 11
      101 051
      Stability-indicating thin-layer chromatographic method for quantitative determination of ribavirin
      I.A. DARWISH*, H.F. ASKAL, A.S. KHEDR, R.M. MAHMOUD (*Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt)

      J. Chromatogr. Sci. 46 (1), 4-9 (2008). Presentation of a simple and accurate stability-indicating method for the quantitative determination of ribavirin in its bulk and capsule forms by TLC on silica gel aluminium layer with chloroform – methanol – acetic acid 4:1:1. Detection by spraying with anisaldehyde reagent. Ribavirin is found to undergo degradation under all stress conditions, and the degradation products are well resolved from the pure drug with significantly different Rf values. Linearity was between 5 and 40 µg/spot (r = 0.9980). The limit of detection and of quantification was 1 and 5 µg/spot, respectively. Application of the proposed TLC method for the determination of ribavirin in pure form and in capsules, with good accuracy and precision. The results obtained by the proposed TLC method are comparable with those obtained by the official method.

      Classification: 32c
      101 077
      Separation and free radical-scavenging activity of major curcuminoids of Curcuma longa using HPTLC-DPPH method
      O. POZHARITSKAYA, S. IVANOVA, A. SHIKOV*, V. MAKAROV (*Interregional Center “Adaptogen”, 47/5 Piskarevskiy pr., St. Petersburg, 195067, Russia, alexs79@mail.ru)

      Phytochem. Anal. 19, 236-243 (2008). HPTLC of curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3) in the rhizome of Curcuma longa L. on silica gel with toluene - acetic acid 4:1 for curcuminoid separation and n-hexane - ethyl acetate - acetic acid 16:5:1 for quantification of total curcuminoid content. Quantitative determination by absorbance measurement at 254 nm. To determine the free radical-scavenging activity of individual compunds, the plate was dipped into a 0.5 mM solution of 1,1-diphenyl-2-picrylhydrazyl (DPPH radical) in methanol for 5 s, dried in darkness at room temperature and heated at 60 °C for 30 s. Quantitative determination by absorbance measurement at 517 nm as negative peaks. The hRf values were 50, and 25 for (1) and (3), respectively. Linearity was between 80 and 250 ng/spot for (1), 40 and 280 ng/spot for (2), and 85 and 270 ng/spot for (3). The limits of detection and quantification were 20 and 60 ng/spot for (1), 10 and 30 ng/spot for (2), and 25 and 75 ng/spot for (3). Recoveries were 99.0 %, 96.9 %, and 95.8 %, (reference value 80 %), respectively. The intermediate/interday/intra-day precision for (1), (2), and (3) was 3.15 %, 3.00 %, and 2.85 %, (n=6), respectively. For the free radical-scavenging activity, linearity was between 70 and 400 ng for (1), 50 and 550 ng for (2), and 60 and 250 ng for (3). The limits of detection and quantification were 40 and 70 ng for (1), 25 and 50 ng for (2), and 45 and 60 ng for (3). The intermediate/interday/intra-day precision for (1), (2), and (3) was 6.50 %, 2.30 %, and 1.50 % (n=6), respectively.

      Classification: 32e
      101 106
      TLC and polarimetric investigation of the oscillatory in-vitro chiral inversion of L-alanine
      M. SAJEWICZ, D. KRONENBACH, M. GONTARSKA, Teresa KOWALSKA* (*Institute of Chemistry, Silesian University, 9 Szkolna Street, 40-006 Katowice, Poland; kowalska@uranos.cto.us.edu.pl)

      J. Planar Chromatogr. 21, 43-47 (2008). TLC and polarimetry was used to investigate the tendency of L-alanine to undergo oscillatory in-vitro chiral inversion when dissolved in neutral, acidic, and basic solvents. The influences of temperature and sample mixing were investigated as well. It was confirmed that L-alanine undergoes chiral inversion. TLC of L-alanine on silica gel, prewashed with methanol - water 9:1, and impregnated twice with aqueous copper sulfate solution and L-proline in water - methanol 9:1. Development with 2-propanol - acetonitrile - water 6:2:3 at 22 °C. Detection by dipping in freshly prepared 0.2 % methanolic ninhydrin solution, followed by heating at 100-110 °C for 10 min. Quantitation by densitometry at 540 nm.

      Classification: 38
      102 029
      Application of densitometry for the evaluation of the separation effect of nicotinic acid derivatives
      Alina PYKA*, W. KLIMCZOK (*Department of Analytical Chemistry, Faculty of Pharmacy, Silesian Academy of Medicine, 4 Jagiellonska Street, 41-200 Sosnowiec, Poland; apyka@slam.katowice.pl)

      Part II. Nicotinic acid and its esters. J. Liq. Chromatogr. Relat. Technol. 30, 2419-2433 (2007). TLC and HPTLC of nicotinic acid and methyl nicotinate, ethyl nicotinate, isopropyl nicotinate, butyl nicotinate, and benzyl nicotinate on RP-18 (prewashed with methanol) with methanol - water and dioxane - water in 10 % volume ratio steps from 100:0 to 0:100 in a chamber saturated for 30 min. TLC on aluminium oxide (prewashed with methanol) with acetone - n-hexane 1:4 provided the optimum conditions for complete separation. Quantitative determination by absorbance measurement at 254 nm.

      Classification: 11a
      102 050
      Thin-layer chromatography-densitometric measurements for determination of N-(hydroxymethyl)nicotinamide in tablets and stability evaluation in solutions
      U. HUBICKA, J. KRZEK*, J. LUKA (*Collegium Medicum of Jagiellonian University, Department of Inorganic and Analytical Chemistry, Medyczna 9, 30-688 Kraków, Poland; jankrzek@cm-uj.krakow.pl)

      J. AOAC Int. 91, 1186-1190 (2008). TLC of N-(hydroxymethyl)nicotinamide on silica gel with chloroform - ethanol 2:3. Quantitative determination by absorbance measurement at 260 nm.

      Classification: 17c
      102 075
      Effect of selected metal ions on the photodegradation of ciprofloxacin in the solid phase
      U. HUBICKA, J. KRZEK* (*Jagiellonian University, Collegium Medicum, Department of Inorganic and Analytical Chemistry, Medyczna 9, 30-688 Krakow, Poland; jankrzek@cm-uj.krakow.pl)

      J. AOAC Int. 91, 1331-1338 (2008). HPTLC of ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(piperazin-1-yl)quinoline-3-carboxylic acid hydrochloride) and degradation products (7-[(2-aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and 7-amino-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid) on silica gel with chloroform - methanol - 25 % ammonia 43:43:14. Detection with 0.3 % methanolic ninhydrin solution and dimethylaminobenzaldehyde and quantitative determination by absorbance measurement at 277 nm.

      Classification: 28a
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