Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
  • Keyword register: select an initial character and browse associated keywords
  • Search by CBS edition: Select a CBS edition and find all related publications

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      102 110
      High performance thin layer chromatographic method for simultaneous estimation of amlodipine besilate and bisoprolol fumarate in pharmaceutical preparations
      R. KAKDE*, V. KOTAK, D. KALE (*R.T.M. University, Dept. of Pharmaceutical Sciences, Nagpur (Ms), India, drkakde@yahoo.com)

      Pharma Review 7(3), 168 - 170 (2008). HPTLC of amlodipine besilate and bisoprolol fumarate on silica gel with methanol - ethyl acetate - ammonia 50:60:5. Quantitative determination by absorbance measurement at 229 nm. The hRf values were 39 and 52 for amlodipine and bisoprolol respectively. The linear rangewas 500-1000 ng/spot for both components. The method was suitable for routine quality control of combine dosage form.

      Classification: 32a
      102 129
      Simultaneous estimation of fluoxetine HCl and olanzapine by HPTLC method in pharmaceutical formulations
      T. Patel*, S. Patel, N. Patel, S. Patel, S. Sheladia (* Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehesan, Gujarat, India)

      60th Indian Pharmaceutical Congress PA-200, (2008). HPTLC of fluoxetine HCl and olanzapine on silica gel with acetone - methanol - triethylamine 10:6:1. Quantitative determination by absorbance measurement at 235 nm. The method was linear in the range of 300-1000 ng/spot for fluoxetine HCl and 50-500 ng/spot for olanzapine respectively. The method was suitable for quality control of combined dosage form.

      Classification: 32a
      102 148
      SIMULTANEOUS ESTIMATION AND VALIDATION OF SIMVASTATIN AND EZETIMIBE BY HPTLC IN PURE AND PHARMACEUTICAl DOSAGE FORMS
      K. Shivshanker*, N. Sreekanth, N. Harikrishnan, C. Roosewelt, P. Pandiyan, G. Rao, V. Gunasekaran (*Dept. of Pharmaceutical Analysis, Vel’s College of Pharmacy, Old Pallavaram, Chennai 600117, India, kalavaivgs30@rediffmail.com)

      Asian J. Chem. 19(5), 3627-3632 (2007). TLC of simvastatin and ezetimibe on silica gel with ethyl acetate - chloroform 4:1. Quantitative determination by absorbance measurement at 220 nm. The hRf value of simvastatin was 76 and of ezetimibe 89. Linearity was between 600 and 1400 µg/mL for simvastatin and ezetimibe. The recovery (by standard addition method) was in the range of 99.7 and 99.6 % for both drugs. The proposed method is precise, accurate and can be used for routine analysis of simvastatin and ezetimibe in tablets.

      Classification: 32a
      102 165
      Enantioseparation of S,R-(+/-)-ketoprofen on plain silica gel layers with achiral mobile phase
      M. SAJEWICZ, G. GRYGIERCZYK, M. GONTARSKA, Teresa KOWALSKA* (*Institut of Chemistry, Silesian University, 9 Szkolna Street, 40-006 Katowice, Poland; kowalska@us.edu.pl)

      J. Liq. Chromatogr. Relat. Technol. 30, 2185-2192 (2007). TLC of S,R-(+/-)-ketoprofen on silica gel (prewashed with methanol - water 9:1) with acetonitrile - water 5:1 containing several drops of acetic acid. Quantitative determination by absorbance measurement at 252 nm. Three different components of the investigated mixture were found which were again separated two-dimensionally in the one dimensional development mode, i. e., their positions differed in terms of the hRf values and the respective migration tracks of these three species all deviated to the right. Earlier tests showed that silica gel employed in the planar chromatographic mode enables two-dimensional enantioseparation of the racemic mixtures in the one-dimensional development mode, without using chiral mobile phases. In the present study this effect was investigated with another racemic mixture from the group of profens. It was concluded that the two-dimensional enantioseparation in the one-dimensional planar chromatographic mode on the microcrystalline silica gel layers is a promising option, enhancing the enantioseparative potential of planar chromatography that cannot be challenged by the column liquid chromatography.

      Classification: 38
      103 042
      Fermentation monitoring based on HPTLC-OPLC
      Elena TAMBURINI*, T. BERNARDI, E. BIANCHINI, P. PEDRINI (*Agro-tech and Pharmaceutical Research Laboratory, Department of Evolutive Biology, University of Ferrara, Ferrara, Italy; tme@unife.it)

      The effect of a complex biological matrix on quantitative performance. J. Planar Chromatogr. 22, 9-14 (2009). HPTLC-OPLC of fructose, glucose, galactose, sucrose, lactose, 1-kestose, raffinose, nystose, and fructosil-nystose on silica gel with acetonitrile - water 17:3. After development and drying, the separated bands were derivatized by a thermal in-situ reaction on a hot plate. The plates were immersed in lead(IV) acetate-dichlorofluorescein reagent for 9 s and heated at 105 °C for 3 min. Quantitative determination by fluorescence measurement at 313 nm.

      Classification: 10a
      103 074
      A new TLC method for quantification of paraquat, diquat, difenzoquat, mepiquat, and chloromequat in water
      M. GÖCER, K. HOFERER, J. ZIPFEL, B. SPANGENBERG* (*University of Offenburg, Institute of Process Engineering, Badstrasse 24, 77652 Offenburg, Germany; Spangenberg@FH-Offenburg.de)

      J. Planar Chromatogr. 22, 59-63 (2009). HPTLC of paraquat, diquat, difenzoquat, mepiquat, and chloromequat on LiChrospher silica gel with 1-propanol - methanol - 2.5 M aqueous sodium chloride 1:1:3. Detection by immersion for 2 s in a solution of 50 mg sodium tetraphenyl borate in 50 mL of water containing 50 µL concentrated hydrochloric acid. The wet plate was illuminated for 5 min with UV light at 254 nm which resulted in the formation of fluorescing spots corresponding to mepiquat, chloromequat, and difenzoquat. Immediately after illuminating at 254 nm all spots were illuminated for 10 min with UV light at 365 nm, which converted all compounds into fluorescent derivatives. Then the dry plate was dipped into ethylene glycol - methanol 1:1 for 2 s, which enhanced the fluorescence by a factor of two. Detection by fluorescence measurement and averaged densitograms were obtained in the emission wavelength range from 440 to 480 nm.

      Classification: 29d
      103 103
      Validated stability-indicating densitometric thin-layer chromatography
      N. JAIN*, G.K. JAIN, F.J. AHMAD, R.K. KHAR (*Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Hamdard Nagar, New Delhi 110062, India)

      Anal. Chim. Acta 599 (2), 302-309 (2007). HPTLC of minocycline on silica gel (impregnated with a 10 % (w/v) solution of disodium ethylene diaminetetraacetic acid (EDTA) with a pH of 9.0) with methanol - acetonitrile - isopropyl alcohol - water 10:8:1:1. Quantitative determination by absorbance measurement at 345 nm. The limit of detection was 3.7 ng/spot, recovery was 99.2 - 100.2 %, and precision was good with a %RSD of 0.4 %. The method was able to separate all degradation products (produced by acidic and basic degradation, oxidation and photodegradation) from the pure drug.

      Classification: 32c
      103 127
      HPTLC method for analysis of whithaferin-A in Ashwagandha (Withania somnifera)
      P.S. NAYAK*, S.D. UPADHYAYA, A. UPADHYAYA (*Department of Crop and Herbal Physiology, College of Agriculture, Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur M. P. 482004 India; preetisagarnayak@rediffmail.com)

      J. Planar Chromatogr. 22, 197-200 (2009). HPTLC of whithaferin A on silica gel with toluene - ethyl acetate - formic acid 5:5:1 in a twin trough chamber saturated for 20 min at 25 +/- 2 °C and 50 +/- 5 % relative humidity. Detection under UV light and by dipping into freshly prepared p-anisaldehyde reagent, followed by heating at 110 °C for 10 min. Quantitative determination by absorbance measurement at 200 nm. The limit of detection and quantification was 100 and 800 ng/zone, respectively. The high sample throughput is useful for routine analysis of the preparation in industrial quality control and regulatory laboratories.

      Classification: 32e
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