Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

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      126 010
      Ligand exchange thin layer chromatographic enantioresolution of (RS)-ketorolac and (RS)-etodolac and recovery of native enantiomers
      P. MALIK, R. BHUSHAN* (Dep. of Chem., Indian Inst. of Technol., Roorkee, Roorkee, India (;

      J. of Chromatogr. Sci. 57 (6), 511-517 (2019). Ligand exchange TLC of (RS)-ketorolac and (RS)-etodolac with different combinations of solvents in different ratios without chiral additive and with Cu(II) as a complexing ion with three enantiomerically pure amino acids, namely, L-tryptophan, L-histidine and L-phenylalanine as chiral dopants. Detection by exposure to iodine vapor and viewing in daylight. The LOD of ketorolac and etodolac was 0.6 and 0.8 μg/zone, respectively. Improvement of the separation efficiency by optimizing different experimental factors, i.e., effect of temperature, mole ratio of Cu(II) to L-amino acids and solvent ratio.

      Classification: 38
      125 055
      Thin-layer chromatographic enantioseparation of atenolol and propranolol using (S)-naproxen as chiral selector: direct and indirect approaches
      V. VASHISTHA, R. BHUSHAN* (*Department of Chemistry, GLA University, Mathura, Uttar Pradesh 281406, India,

      J. Planar Chromatogr. 33, 101-107 (2020). HPTLC of (RS)-atenolol and (RS)-propranolol on silica gel  impregnated with 50 mM (S)-naproxen as chiral selector with acetonitrile - dichloromethane - water 6:2:1 pH = 5 for (RS)-atenolol and 7:3:1 pH = 5 for (RS)-propanolol. Detection by exposure to iodine vapor. The LOD was 1.2 and 1.6 µg/mL for (1) and (2), respectively. The chiral selector allowed the separation of atenolol and propranolol with a resolution of 2.4.

      Classification: 38
      124 019
      Thin-layer chromatographic enantioresolution of (RS)-ketorolac using L-amino acids as chiral additive in stationary phase
      M. SINGH*, R. BHUSHAN (*Department of Chemistry, Lovely Professional University, Phagwara 144411, Punjab, India,

      J. Planar Chromatogr. 32, 475-479 (2019). TLC of enantiomers of (RS)-ketorolac on home-made silica gel plates impregnated with L-Tryp (1), L-Val (2), L-Met (3) or L-His (4) with acetonitrile - methanol - water - chloroform 9:5:2:4 for (1), acetonitrile - methanol - water - dichloromethane 6:2:1:1 for (2), acetonitrile - methanol - water - chloroform 5:3:1:1 for (3) and acetonitrile - methanol - water - chloroform 10:4:1:5 for (4), respectively. Detection by exposure to iodine vapors. The hRF values for (S)-(‒)- and (R)-(+)-ketorolac were 36 and 81 for (1), 30 and 79 for (2), 30 and 87 for (3) and 42 and 85 for (4), respectively. LOD was 0.4 μg/mL.

      Classification: 38
      123 060
      Superiority of Thin-Layer Chromatography over High-Performance Liquid Chromatography in enantioseparation
      D. SINGH, P. MALIK, R. BHUSHAN (*Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India,

      J. Planar Chromatogr. 32, 7-12 (2019). HPTLC of (RS)-mexiletine on RP-18 plates impregnated with 0.03 mM bovine serum albumin as chiral additive with acetonitrile - dichloromethane - methanol 1:1:1. Detection by exposure to iodine vapors. Resolution was 2.3 for the HPTLC method and 1.9 using an HPLC method. The HPTLC analysis took nearly 7 min, whereas HPLC took nearly 265 min to get the results.

      Classification: 38
      100 186
      Development of a direct TLC method for separation of isomers of carvedilol using beta-cyclodextrin as a chiral selector in stationary phase
      P. PATEL*, R. MASHRU (Dept. Pharmaceutics, Ramanbhai Patel College of Pharmacy, Changa, Gujarat, India)

      59th Indian Pharmaceutical congress F-211, 440, (2007). TLC of isomers of carvedilol on chiral silica gel (prepared with beta-cyclodextrin) with methanol - water 5:1. Evaluation at 366 nm. The R(+) and the S(-) isomer of carvedilol had hRf values of 89 and 81, respectively. The linearity range was 50 - 500 µg/zone. Limit of detection and quantification was 10, 12 and 40, 42 µg/zone respectively for R(+) and S(-) isomers. The preparation of R(+) and S(-) isomers of carvedilol was found to be in the ratio 3:2 in bulk and formulations.

      Classification: 38
      106 182
      Different approaches of impregnation for resolution of enantiomers of atenolol, propranolol and salbutamol using Cu(II)-L-amino acid complexes for ligand exchange on commercial thin-layer chromatographic plates
      R. BHUSHAN*, Shivani TANWAR (*Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India)

      J. Chromatogr. A 1217(8), 1395-1398 (2010). TLC of atenolol, propranolol and salbutamol and their enantiomers by using different modes of loading/impregnating the Cu(II) complexes of L-proline, L-phenylalanine, L-histidine, N,N-dimethyl-L-phenylalanine, and L-tryptophan on silica gel with 1) the Cu(II)-L-amino acid complex as chiral mobile phase additive, 2) ascending development of plain commercial plates in the solutions of Cu complex, and 3) using a solution of Cu(II)acetate as mobile phase additive for the commercial TLC plates impregnated by development with the amino acid solutions. Detection by exposure to iodine vapor. The detection limit was 0.18 µg for each enantiomer. For the best method performance the Cu(II)cation has to be involved.

      Classification: 38
      117 132
      A validated direct thin-layer chromatographic separation and enantioselective determination of racemic centrally acting drugs using ion-pair and ligand-exchange chiral selectors
      N. SALAMA, H. ZAAZAA, L. EL HALIM*, M. SALEM, L. EL FATTAH (*Pharmaceutical Chemistry Department, National Organization for Drug Control and Research (NODCAR), 6 Abu Hazem Street, Pyramids Ave, P.O. Box 29, Giza, Egypt,

      J. Planar Chromatogr. 29, 176-183 (2016). HPTLC of atracurium besylate (1) and atropine sulfate (2) on silica gel with acetonitrile – methanol – dichloromethane – glacial acetic acid – water containing 70 mg L-(+)-tartaric acid 70:10:5:7:1, pH 5 for (1), and methanol – water containing 40 mg L-histidine and 20 mg copper(II) acetate 22:3, pH 7 for (2). Quantitative determination by absorbance measurement at 280 nm for (1) and 215 nm for (2). The hRF values for (1) and (2) were 51 and 65, respectively. Linearity was in the range of 2-14 μg/zone for (1) and 5-35 μg/zone for (2). Intermediate precisions were below 1 %. The LOD and LOQ were 0.5 and 1.6 µg/zone for (1) and 1.2 and 3.6 µg/zone for (2). Average recovery was found to be 103.4 % for (1) and 96.6 % for (2).

      Classification: 38
      63 210
      Enantiomeric separation of chiral carboxylic acids, as their diastereomeric carboxamides, by thin-layer chromatography
      P. SLEGEL, G. VERECZKEY-DONATH, L. LADANYI, M. TOTH-LAURITZ, (EGIS Pharm., 1475 Budapest, Hungary)

      J. Pharm. Biomed. Anal. 5, 665-673 (1987). Description of a TLC method for enantiomeric separation of chiral carboxylic acids using chiral derivatization and non-chiral TLC conditions to separate diastereomeric carboxamides using „levobase“, (1R, 2R)- (-)-1- (4-nitrophenyl)-2-amino-1, 3-propanediol, and „dextrobase“; the enantiomers of levobase, as chiral derivatizing agents for carboxamide formation in the presence of dicyclohexylcarbodiimide as coupling agent. Good resolution was obtained for a wide range of carboxylic acid enantiomeric pairs containing 1 to 2 chiral centers .

      Classification: 11a, 38