Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
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Registered users can create a tailor made PDF of selected articles throughout CCBS search – simply use the cart icon on the right hand of each abstract to create your individual selection of abstracts. The saved items can be printed to PDF using the print function of your web browser.

      Superiority of Thin-Layer Chromatography over High-Performance Liquid Chromatography in enantioseparation
      D. SINGH, P. MALIK, R. BHUSHAN (*Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India, rbushfcy54@gmail.com)

      J. Planar Chromatogr. 32, 7-12 (2019). HPTLC of (RS)-mexiletine on RP-18 plates impregnated with 0.03 mM bovine serum albumin as chiral additive with acetonitrile - dichloromethane - methanol 1:1:1. Detection by exposure to iodine vapors. Resolution was 2.3 for the HPTLC method and 1.9 using an HPLC method. The HPTLC analysis took nearly 7 min, whereas HPLC took nearly 265 min to get the results.

      Classification: 38
      100 186
      Development of a direct TLC method for separation of isomers of carvedilol using beta-cyclodextrin as a chiral selector in stationary phase
      P. PATEL*, R. MASHRU (Dept. Pharmaceutics, Ramanbhai Patel College of Pharmacy, Changa, Gujarat, India)

      59th Indian Pharmaceutical congress F-211, 440, (2007). TLC of isomers of carvedilol on chiral silica gel (prepared with beta-cyclodextrin) with methanol - water 51. Evaluation at 366 nm. The R(+) and the S(-) isomer of carvedilol had hRf values of 89 and 81, respectively. The linearity range was 50 - 500 µg/zone. Limit of detection and quantification was 10, 12 and 40, 42 µg/zone respectively for R(+) and S(-) isomers. The preparation of R(+) and S(-) isomers of carvedilol was found to be in the ratio 32 in bulk and formulations.

      Classification: 38
      106 182
      Different approaches of impregnation for resolution of enantiomers of atenolol, propranolol and salbutamol using Cu(II)-L-amino acid complexes for ligand exchange on commercial thin-layer chromatographic plates
      R. BHUSHAN*, Shivani TANWAR (*Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India)

      J. Chromatogr. A 1217(8), 1395-1398 (2010). TLC of atenolol, propranolol and salbutamol and their enantiomers by using different modes of loading/impregnating the Cu(II) complexes of L-proline, L-phenylalanine, L-histidine, N,N-dimethyl-L-phenylalanine, and L-tryptophan on silica gel with 1) the Cu(II)-L-amino acid complex as chiral mobile phase additive, 2) ascending development of plain commercial plates in the solutions of Cu complex, and 3) using a solution of Cu(II)acetate as mobile phase additive for the commercial TLC plates impregnated by development with the amino acid solutions. Detection by exposure to iodine vapor. The detection limit was 0.18 µg for each enantiomer. For the best method performance the Cu(II)cation has to be involved.

      Classification: 38
      117 132
      A validated direct thin-layer chromatographic separation and enantioselective determination of racemic centrally acting drugs using ion-pair and ligand-exchange chiral selectors
      N. SALAMA, H. ZAAZAA, L. EL HALIM*, M. SALEM, L. EL FATTAH (*Pharmaceutical Chemistry Department, National Organization for Drug Control and Research (NODCAR), 6 Abu Hazem Street, Pyramids Ave, P.O. Box 29, Giza, Egypt, lobna_nodcar@yahoo.com)

      A validated direct thin-layer chromatographic separation and enantioselective determination of racemic centrally acting drugs using ion-pair and ligand-exchange chiral selectors a thermodynamic study of complexation. J. Planar Chromatogr. 29, 176-183 (2016). HPTLC of atracurium besylate (1) and atropine sulfate (2) on silica gel with acetonitrile – methanol – dichloromethane – glacial acetic acid – water containing 70 mg L-(+)-tartaric acid 7010571, pH 5 for (1), and methanol – water containing 40 mg L-histidine and 20 mg copper(II) acetate 223, pH 7 for (2). Quantitative determination by absorbance measurement at 280 nm for (1) and 215 nm for (2). The hRF values for (1) and (2) were 51 and 65, respectively. Linearity was in the range of 2-14 ?g/zone for (1) and 5-35 ?g/zone for (2). Intermediate precisions were below 1 %. The LOD and LOQ were 0.5 and 1.6 µg/zone for (1) and 1.2 and 3.6 µg/zone for (2). Average recovery was found to be 103.4 % for (1) and 96.6 % for (2).

      Keywords:
      Classification: 38
      63 210
      Enantiomeric separation of chiral carboxylic acids, as their diastereomeric carboxamides, by thin-layer chromatography
      P. SLEGEL, G. VERECZKEY-DONATH, L. LADANYI, M. TOTH-LAURITZ, (EGIS Pharm., 1475 Budapest, Hungary)

      J. Pharm. Biomed. Anal. 5, 665-673 (1987). Description of a TLC method for enantiomeric separation of chiral carboxylic acids using chiral derivatization and non-chiral TLC conditions to separate diastereomeric carboxamides using „levobase“, (1R, 2R)- (-)-1- (4-nitrophenyl)-2-amino-1, 3-propanediol, and „dextrobase“; the enantiomers of levobase, as chiral derivatizing agents for carboxamide formation in the presence of dicyclohexylcarbodiimide as coupling agent. Good resolution was obtained for a wide range of carboxylic acid enantiomeric pairs containing 1 to 2 chiral centers .

      Keywords:
      Classification: 38, 11a
      69 125
      Enantiomerenreine Arzneistoffe
      S. LÜBBEN*, J. MARTENS, B. RODER, (*Fachbereich 9, Organische Chemie, Universität Odenburg, D-2900 Oldenburg, Postfach 2503, FRG)

      Nachweis mittels DC. (Pure enantiomeric drugs. Identification by densitometry.) Deutsche Apotheker Zeitung 132, 947 –952 (1992). TLC of amino acids, a-methyl amino acids on chiral plates and RP-18 silica with methanol – water – acetonitrile 114 and 553, also with methanol – water 18 and acetone – methanol – water 1022). Detection by spraying with 0,3% ninhydrin in acetone.

      Classification: 18, 38
      73 175
      TLC resolution of DL amino acids on impregnated silica gel plates
      R. BUSHAN, G.P. REDDY, S. JOSHI, (Dept. of Chem., Univ. of Roorkee, Roorkee - 247667, India)

      J. Planar Chromatogr. 7, 126-128 (1994). TLC resolution of racemic amino acids on silica gel impregnated with a complex of copper and L-proline. The solvent systems found to be successful were butanol - acetonitrile - water 623, chloroform - methanol - propionic acid 1564, and acetonitrile - methanol - water 221. Experimental details for preparing the impregnated plates are described.

      Keywords:
      Classification: 38
      75 094
      Relationship between capacity factors and mobile phase composition and thin layer ligand exchange chromatography of the enantiomers of some amino acids
      W. GOLKIEWICZ, B. POLAK, (Dept. of Inor. and Anal. Chem., Med. Acad., 20-081 Lublin, Poland)

      J. Planar Chromatogr. 7, 453-457 (1994). HPTLC separation of some a-amino acids on commercially available reversed phase TLC plates treated with a derivative of 4-hydroxyproline as chiral selector. The chromatographic behavior of ternary mixed-ligand complexes of a-amino acids can be described by an equation used in reversed phase chromatography. For some organic solvents there is a linear relationship between RM values and the volume fraction of modifier.

      Keywords:
      Classification: 18, 38