Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
  • Keyword register: select an initial character and browse associated keywords
  • Search by CBS edition: Select a CBS edition and find all related publications

Registered users can create a tailor made PDF of selected articles throughout CCBS search – simply use the cart icon on the right hand of each abstract to create your individual selection of abstracts. The saved items can be printed to PDF using the print function of your web browser.

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      126 020
      New hirsutinolide-type sesquiterpenoids from Vernonia cinerea inhibit nitric oxide production in LPS-stimulated RAW264.7 cells
      Li-Ming YANG KUO, Pei-Yi TSENG, Yu-Chi LIN, Chia-Ching LIAW, Li-Jie ZHANG, Keng-Chang TSAI, Zhi-Hu LIN, Hsiu-O HO*, Yao-Haur KUO (*School of Pharmacy, Taipei Medical University, Taipei, Taiwan; hsiuoho@tmu.edu.tw)

      Planta Med. 84(18), 1348-1354 (2018). A subfraction (obtained through liquid-liquid partition and column chromatography) of the ethanolic extract of whole Vernonia cinerea plants (Asteraceae, subf. Cichorioideae) was further fractioned by reverse-phase SPE (solid-phase extraction) followed by preparative TLC on silica gel layer (eluent not given). For verification, zones were detected by spraying with anisaldehyde solution with 10 % sulfuric acid, followed by heating at 100 °C. Further purification by reverse-phase HPLC allowed the isolation of 6 hirsutinolide-type sesquiterpenoids (all with a oxacyclonane forming an ether bridge), including vernolides A and B.

      Classification: 8b, 9, 15a, 32e
      126 019
      Anti-inflammatory four new 2-(2-phenylethyl)-4H-chromen-4-one derivatives from the resinous wood of Aquilaria sinensis and their inhibitory activities on neutrophil pro-inflammatory responses
      S. WANG (Wang Sin-Ling), H. LIAO (Liao Hsiang-Ruei), M. CHENG (Cheng Ming-Jen), C. SHU (Shu Chih-Wen), C. CHEN (Chen Chun-Lin), M. CHUNG (Chung Mei-Ing)*, J. CHEN (Chen Jih-Jung) (*School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; meinch@kmu.edu.tw)

      Planta Med. 84(18), 1340-1347 (2018). Preparative TLC on silica gel for the final purification of 15 phenylethyl-chromenone derivatives (including 3 with epoxide functions), 4 sesquiterpenoids (neopetasane, dehydrokaranone, dioxoselinene, ligudicin C) and a steroid (ergostatetraenone), all isolated through multi-step column chromatography from the ethyl-acetate fraction of a methanolic extract of Aquilaria sinensis resinous wood (Thymelaeaceae). For each compound, mobile phase, RF value and yield are given.

      Classification: 8b, 9, 15a, 32e
      126 001
      A sensitive HPTLC method for the estimation of glibenclamide, rosiglitazone maleate and metformin hydrochloride from a multicomponent dosage form
      S.D. BHENDE*, M. BALARAM VARANASI, K. ABBULU (*Dep. of Pharm. Sci., Jawaharlal Nehru Technol. Univ. Hyderabad, Kukatpally, Hyderabad, Telangana 500085, India, bhende_swati@rediffmail.com)

      J. of Chromatogr. Sci. 58 (5), 418 - 426 (2020). Development of a method for the quantitation of glibenclamide (GLIBEN), rosiglitazone maleate (ROSI) and metformin hydrochloride (MET) from a combined dosage form by HPTLC on RP-18 F254s aluminum layer with methanol - tetrahydrofuran - water - glacial acetic acid 40:9:10:1. Detection under UV light. The hRf for GLIBEN, ROSI and MET was 54, 62 and 80, respectively. Quantification and photodocumentation by densitometry. For GLIBEN and  ROSI the LOD and LOQ was 80 and 200 ng/zone, for MET the LOD and LOQ was 48 and 120 ng/zone, respectively. The linearity for GLIBEN and ROSI was 200 - 1000 ng/zone (r = 0.9991 for GLIBEN and r = 0.9993 for ROSI) and for MET 120 - 600 ng/zone (r = 0.9988). The method was precise and accurate for all three drugs, and well suitable for the analysis of triglucored tablets, and reliable quality control for GLIBEN, ROSI and MET in a combined dosage form.

       

      Classification: 32a
      126 002
      (Study of the method for the quality control of Yiqi Tongmai capsules by thin-layer chromatography) (Chinese)
      Y. KONG (KONG YAN), J. WANG (WANG JAN)* (*Yangzhou Munic. Center for Food & Drug Contr., Jiangsu, Yangzhou, 225009, China, dss-now@126.com)

      J. Chinese Trad. Patent Med. 41 (3), 516-521 (2019). Yiqi Tongmai Capsule is a herbal TCM for activating blood circulation and regulating veins, as to relieve dizziness, chest tightness, chest pain caused by blood stasis. HPTLC for quality control on silica gel (1) for Ligusticum chuanxiong hort, with n-hexane - ethyl acetate 3:1 after presaturation of plates for 20 min, detection under UV 366 nm; (2) for Radix paeoniae rubra, with chloroform - ethyl acetate - methanol - formic acid 80:10:40:1 after presaturation of plates for 20 min, detection by spraying with 5 % vanilline in sulfuric acid - ethanol 1:4 and heating at 105 ˚C until the zones are detected in daylight, comparison with the standard  paeoniflorin; (3) for Panacis Quinquefolii Radix and Panaxnotoginseng (Burk.) F.H.Chen with trichloroform - anhydrous ethanol - water 10:10:1 after presaturation of plates for 15 min, detection by spraying with 10 % solution of sulfuric acid - ethanol 1:4 and heating at 105 ˚C until the zones are detected in daylight and under UV 366 nm, identification by comparison with the standards notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and pseudoginsenoside F11.

      Classification: 32e
      126 003
      HPTLC separation of a hepatoprotective combination in pharmaceutical formulation and human plasma
      M.A. MAGDY*, R.M. ABDELFATAH (*Pharm. Anal. Chem. Dep., El shaheed Ahmed Hegazy Street, Faculty of Pharmacy, Beni Suef Univ., Beni Suef 90706, Egypt, maimanamagdy@yahoo.com)

      J. of Chromatogr. Sci. 58 (5), 411 - 417 (2020). Analysis of a binary mixture of silymarin (SR) and vitamin E (VE) acetate in their pure forms, pharmaceutical formulation and spiked human plasma, by HPTLC on silica gel with hexane - acetone - formic acid 140:60:3, detection at UV 215 nm, and quantification by densitometry. The linearity was 0.2 - 2.5 and 0.2 - 4.5 μg/band for SR and VE, respectively. Accuracy was 99.9 ± 1.2 % and 100.2 ± 1.6 % for SR and VE, respectively. The method was successfullly used for the determination of the studied drugs in their pharmaceutical formulation without any interference from excipients, and in spiked plasma samples. Statistical comparison of the results obtained by this HPTLC method showed no significant difference to the results obtained by the reported HPLC method.

      Classification: 32, 32e
      126 003
      HPTLC separation of a hepatoprotective combination in pharmaceutical formulation and human plasma
      M.A. MAGDY*, R.M. ABDELFATAH (*Pharm. Anal. Chem. Dep., El shaheed Ahmed Hegazy Street, Faculty of Pharmacy, Beni Suef Univ., Beni Suef 90706, Egypt, maimanamagdy@yahoo.com)

      J. of Chromatogr. Sci. 58 (5), 411 - 417 (2020). Analysis of a binary mixture of silymarin (SR) and vitamin E (VE) acetate in their pure forms, pharmaceutical formulation and spiked human plasma, by HPTLC on silica gel with hexane - acetone - formic acid 140:60:3, detection at UV 215 nm, and quantification by densitometry. The linearity was 0.2 - 2.5 and 0.2 - 4.5 μg/band for SR and VE, respectively. Accuracy was 99.9 ± 1.2 % and 100.2 ± 1.6 % for SR and VE, respectively. The method was successfullly used for the determination of the studied drugs in their pharmaceutical formulation without any interference from excipients, and in spiked plasma samples. Statistical comparison of the results obtained by this HPTLC method showed no significant difference to the results obtained by the reported HPLC method.

      Classification: 32, 32e
      126 005
      A validated green HPTLC method for quantitative determination of dapoxetine hydrochloride and tadalafil in bulk and pharmaceutical formulations
      I.A. NAGUIB, M.A. MAGDY, B.H. ANWAR*, N.S. ABDELHAMID (*Pharm. Anal. Chem. Dep., Fac. of Pharmacy, Beni-Suef Univ., Alshaheed Shehata Ahmad Hegazy St., 62514, Beni-Suef, Egypt, bassma.hossam@hotmail.com)

      J. of Chromatogr. Sci. 58 (4), 303 - 308 (2020). Determination of dapoxetine hydrochloride (DAP) and tadalafil (TAD) in their binary mixtures either as raw materials or in pharmaceutical formulations, by HPTLC on silica gel with ethanol - ethyl acetate 1:9. Quantitative determination by densitometry at 222 nm. The linear range was 0.1 - 1.6 and 0.2 - 2.5 μg/band for dapoxetine and tadalafil, respectively, with accuracies of 98.9 % ± 0.6 and 99.3 6% ± 1.4, respectively.

      Classification: 32a
      126 006
      Development and validation of HPTLC and green HPLC methods for determination of a new combination of quinfamide and mebendazole
      I.A. NAGUIB, E.S. HASSAN*, A.A. EMAM, E.A. ABDELALEEM (*Pharm. Anal. Chem. Dep., Beni-Suef Univ., Alshaheed Shehata Ahmad Hegazy St., Beni-Suef 62514, Egypt, dr.emansherif@yahoo.com)

      J. of Chromatogr. Sci. 58 (1), 16 - 21 (2020). Development of a selective and sensitive method for the simultaneous determination of a new combination of quinfamide and mebendazole in bulk powder and in pharmaceutical formulation by HPTLC on silica gel with methanol - toluene 1:3. Quantitative determination by densitometry at 254 nm. Validation of the method according to ICH guidelines. Successful application for determination of quinfamide and mebendazole in tablets. Statistical comparison between the developed HPTLC method and a reported simultaneous equation spectrophotometric method showed no significant difference, proving the suitability for quality control testing of the studied drugs.

      Classification: 32a
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