Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      (Study of the method for the quality control of Dabaidu Jiaonang capsules by thin-layer chromatography) (Chinese)
      Y. GAO (Gao Yi), H. LI (Li Hui), W. CHEN (Chen Wenyan), SH. HUANG (Huang Shengliang), X. QUAN (Qian Xiaohua), L. ZHANG (Zhang Li)* (*Nanjing Univ. of Chinese Med., Nanjing 210023, China)

      J. Chinese Trad. Patent Med. 40 (11), 2450-2454 (2018). Dabaidu Jiaonang capsules are used for clearing blood poison and relieving swelling and pain. For quality control, TLC of its extracts, the respective reference drug and selected standards on silica gel (1) for Rheum palmatum L., with petroleum ether (30-60 ˚C) – ethyl formate – formic acid 15:5:1, detection under UV 365 nm; (2) for Cortex phellodendri (and berberine hydrochloride), with n-butanol – glacial acidic acid – water 7:1:2, detection under UV 365 nm; (3) for Radix paeoniae rubra (and paeoniflorin), with chloroform – ethyl acetate – methanol – formic acid 40:5:10:0.2, detection by spraying with 5% vanilline in H2SO4 – ethanol 1:4 and heating at 85 ˚C until the zones are visible in daylight; (4) for Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav (and iso-/imperatorin), with petroleum ether (30-60 ˚C) – diethyl ether 3:2, detection under UV 365 nm; (5) for Pericarpium citri reticulatae (and hesperidin), first with ethyl acetate – methanol – water 100:17:13 up to 30 mm, then with the upper phase of toluene – ethyl acetate – formic acid – water 20:10:1:1 up to 80 mm, detection by spraying with 5% AlCl3 in ethanol and viewing under UV 365 nm; (6) for Boswellia carteri, with cyclohexane – ethyl acetate 11:2, detection by spraying with 5% vanilline in H2SO4 – ethanol 1:4 and heating at 85 ˚C until the zones are visible in daylight. Quantification of aloe emodin, rhein, emodin, chrysophanol, physcion by HPLC.

      Keywords:
      Classification: 32e
      Thin-layer chromatography in medicinal chemistry
      Sandra SEGAN, D. OPSENICA, Dusanka OPSENICA* (*Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, P.O. Box 51, 11158 Belgrade, Serbia, dusankam@chem.bg.ac.rs)

      J. Liq. Chromatogr. Relat. Technol. 42, 238-248 (2019). Review of recent applications of TLC in medicinal chemistry, including the determination of lipophilicity of biologically active compounds and its influence as activity descriptors of absorption, distribution, metabolism, elimination and toxicity. Practical applications of TLC as a fast screening technique in different stages of monitoring processes were also described, including systems recently used for stability studies of selected drugs.

      Classification: 32a, 1a
      Diterpene lipo-alkaloids with selective activities on cardiac K+ channels
      T. KISS, B. BORCSA, P. ORVOS, L. TÁLOSI, J. HOHMANN, D. CSUPOR* (*Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary; csupor.dezso@pharmacognosy.hu)

      Planta Med. 83(17), 1321-1328 (2017). Benzoyl-aconine esters (lipo-alkaloids) produced by transesterification of aconitine (isolated from Aconitum sp.) with long-chain fatty acids were purified by a multistep chromatographic method, including cyclodextrane gel filtration chromatography, centrifugal planar chromatography on aluminium oxide layer using cyclohexane – chloroform – methanol 70:30:1 followed by 70:30:3 and/or preparative thin-layer chromatography on aluminium oxide layer with toluene – acetone – ethanol – concentrated ammonia 70:40:10:3.

      Classification: 32e, 22, 11a, 4d, 4e
      Terpenoids from leaves of Guarea macrophylla display in vitro cytotoxic activity and induce apoptosis in melanoma cells
      Geanne Alexandra A. CONSERVA, N. GIROLA, C.R. FIGUEIREDO, R.A. AZEVEDO, S. MOUSDELL, P. SARTORELLI, M.G. SOARES, G.M. ANTAR, J.H.G. LAGO* (*Centre of Natural and Human Sciences, Federal University of the ABC, Santo-André, State of São Paulo, Brazil; joao.lago@ufabc.edu.br)

      Planta Med. 83(16), 1289-1296 (2017). A cycloartene-diol, a dihydroxycicloartenone and an isopimaradiene-diol were isolated from subfractions of an ethanolic extract of Guarea macrophylla (Meliaceae) leaves through elution on preparative TLC silica gel layers with chloroform – acetone 19:1, or with n-hexane – ethyl acetate 9:1 or 1:1, respectively.

      Classification: 32e, 15a
      Microscopic and phytochemical comparison of the three Leonurus species L. cardiaca, L. japonicus, and L. sibiricus
      Anna PITSCHMANN, C. WASCHULIN, C. SYKORA, S. PUREVSUREN, S. GLASL* (*Department of Pharmacognosy, University of Vienna, Vienna, Austria; sabine.glasl@univie.ac.at)

      Planta Med. 83(14/15), 1233-1241 (2017). HPTLC of standards and methanolic extracts of L. cardiaca, L. japonicus and L. sibiricus (Lamiaceae) acidified with formic acid on silica gel with ethyl acetate – acetic acid – formic acid – water 100:11:11:26, in an automatic development chamber with 48 % humidity (20 min presaturation). Detection under white and UV light, before and after immersion in 1) anisaldehyde – sulphuric acid (followed by heating) for the detection of iridoids; 2) natural product reagent A for phenylpropanoids; 3) modified Dragendorff reagent (bismuth oxynitrate 0.17 %, sulfuric acid 3.5 %, glacial acetic acid 2 %, potassium iodide 4 %) for alkaloids. Ajugoside (hRF 29) and verbascoside (hRF 53) were found in L. cardiaca and L. sibiricus, but absent in L. japonicus. The opposite was true for leonurine (hRF 52), whereas stachydrine (hRF 14) was found in the three species. This method allows to distinguish L. japonicus from the other species, which have to be distinguished from each other through morphology.

      Classification: 32e, 22, 8
      Simultaneous High-Performance Thin-Layer Chromatographic Quantification of withaferin A and withanolide A in Solanum nigrum L. "Black Nightshade"
      R. PREET*, R. GUPTA, M. KAUR (*Department of Botany, Punjabi University, Patiala, India, ramanbrar247@gmail.com)

      J. Planar Chromatogr. 32, 339-342 (2019). HPTLC of withanolide A (1) and withaferin A (2) on silica gel with toluene - ethyl acetate - formic acid - ethanol 60:30:1:6. Detection by spraying with p-anisaldehyde sulfuric acid (prepared by dissolving 1 mL of p-anisaldehyde solution in 2 mL of concentrated sulfuric acid and 100 mL of acetic acid). Quantitative determination by absorbance measurement at 530 nm. The hRF values for (1) and (2) were 43 and 55, respectively. 

      Classification: 32a
      Factor optimization study to develop and validate a reversed-phase Thin-Layer Chromatography method for the determination of trimetazidine dihydrochloride and its reported impurities in pharmaceuticals
      Suzan MAHMOUD SOLIMAN (National Organization for Drug Control and Research (NODCAR), El-Lagousa 51 Wezaret El-Ziraa St, Giza, Egypt, suzansoliman1961@hotmail.com)

      J. Planar Chromatogr. 32, 273-283 (2019). HPTLC of trimetazidine dihydrochloride (1) and its potential impurities, namely, piperazinecarboxaldehyde (2), trimethoxybenzyl alcohol (3), and trimethoxybenzaldehyde (4) on RP-18 with acetonitrile - methanol - 0.1 % aqueous ortho-phosphoric acid (pH 6.2) 9:9:2. Quantitative determination by absorbance measurement at 254 nm. The hRF values for (1) to (4) were 21, 35, 50 and 85, respectively. Linearity was between 0.05-10 µg/zone for (1), 0.05-1.1 µg/zone for (2), 0.05-1.2 µg/zone for (3) and 0.04-1.0 µg/zone for (4). The intermediate precision was below 2 % (n=9). The LOD and LOQ were 20 and 50 ng/zone for (1) to (3) and 15 and 40 ng/zone for (4), respectively. Recovery rate was 99.6 % for (1), 100.5 % for (2), 100.1 % for (3) and 99.4 % for (4).

      Classification: 32a
      Development of an analytical method for identification of the genotoxic impurity of quetiapine fumarate by High-Performance Thin-Layer Chromatography
      P. MINIYAR*, A. THOMAS, R. KULKARNI, S. KADAM, P. CHOUHAN, S. CHITLANGE (* Sinhgad Technical Education Society’s Sinhgad Institute of Pharmacy, Narhe, Pune – 411041, India miniyarpankaj@gmail.com)

      J. Planar Chromatogr. 32, 317-321 (2019). HPTLC of 2-chloroaniline (1) at trace levels
      in quetiapine fumarate (2) on silica gel with toluene and methanol 7:4. Quantitative determination by absorbance measurement at 235 nm. The hRF value of (1) was 85. Linearity was between 2.5-12.5 ng/zone for (1) and 400-2400 ng/zone for (2). The intermediate precision was below 2 % (n=3). The LOD and LOQ of (1) were 0.02 and 0.05 ng/zone for (1) [Editor´s note: This seems to be erroneous.] and 1.27 and 3.87 ng/zone for (2), respectively. Recovery rate ranged between 98 and 100 % for (1) and (2).

      Classification: 32a
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