Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
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      69 155
      Assay and purity control of metacycline by thin-layer chromatography combined by UV and fluorescence densitometry - A comparison with liquid chromatography
      S. HUA, K. VERRESEN, E. ROETS, J. HOOGMARTENS

      J. Pharm. Biomed. Anal. 9, 717-723 (1991). TLC of antibiotic metacycline and its major impurities oxytetracycline, 4-epimetacycline, doxycycline, 2-acetyl-2-decarboxamidometacycline and 6-epidoxycycline on silica pretreated with EDTA/sodium hydroxide with dichloromethane – methanol water 58:35:7. Detection under UV; quantification by densitometry at 254 nm.

      Classification: 28
      85 094
      The application of HPTLC in the quantitative analysis of drugs
      D. AGBABA, S. ERIC, G. MARKOVIC, V. NEDELJKOVIC, S. VESELINOVIC, M. VUCETIC, (School of Pharm., Dept. of Pharm. Chem., P.O. Box 146, 11221 Belgrade and Galenska Lab., Zajecar, Yugoslavia)

      Sz. Nyiredy, A. Kakuk (eds.): Planar Chromatography 2000, Lillafüred, Hungary, 24-26 June 2000, Res. Inst. for Med. Plants, p. 143-148. Validated methods: HPTLC of dexamethasone sodium phosphate and neomycin sulfate on silica gel with concentration zone with chloroform - 1-propanol - NH3 1:3:2. HPTLC of ketoconazole on silica gel with n-hexane - acetone 4:1. HPTLC of coenzyme Q10 on silica gel with n-hexane - chloroform - methanol 5:4:1. Quantitation by polynomial regression at 246 nm for dexamethasone sodium phosphate, at 230 nm for ketoconazole, at 275 nm for coenzyme Q10 and after derivatization with ninhydrin solution at 500 nm for neomycin. Precision is found to be between 0,8-2,68 %.

      Keywords:
      Classification: 28, 32a
      104 053
      Validation of an analytical method for the determination of spiramycin, virginiamycin, and tylosin in feeding-stuffs by thin-layer chromatography and bio-autobiography
      U. VINCENT, G. GIZZI, C. VON HOLST*, J. DE JONG, J. MICHARD (*European Commission, Joint Research Centre, Insitutute for Reference Materials and Measurements, Food Safety and Quality Unit, Retieseweg, 2440 Geel, Belgium, christoph.von-holst@ec.europa.eu).

      Food Addit. Contam. 24, 351-359 (2007). Inter-laboratory validation of the analytical method (published in the SIMBAG-FEED report 4.6) based on TLC coupled to bio-autography for the detection of tylosin, spiramycin and virginiamycin in feeding-stuffs for poultry, pig, cattle and calf. The detection limit of spiramycin was 2 mg/kg and the method has a target concentration of 1 mg/kg for tylosin and virginiamycin. The method showed high specificity and offers the possibility for screening before LC/MS analysis.

      Classification: 28a
      109 062
      Stability-indicating TLC-image analysis method for quantification of ceftriaxone sodium in pharmaceutical dosage form
      P. PHATTANAWASIN*, U. SOTANAPHUN, L. SRIPHONG, I. KANCHANAPHIBOL (*Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand; ypanadda@su.ac.th)

      J. Planar Chromatogr. 24, 30-34 (2011). TLC of ceftriaxone sodium on RP-18 with 15 % ammonium acetate buffer (pH 6.2) - methanol - acetonitrile 48:2:1 after saturation of the chamber for 20 min. Detection under UV light at 254 nm. Quantitative determination by densitometry in absorbance mode at 302 nm as well as by use of TLC-image analysis. Linearity was between 1-8 µg/zone. LOD and LOQ were 228 and 759 ng/zone, respectively. The hRf value of ceftriaxone sodium was 58.

      Classification: 28a
      113 058
      Simultaneous estimation of azithromycin dehydrate and cefixime trihydrate in pharmaceutical formulation by HPTLC method
      P. RAVAL*, F. MEHTA, K. AHIR, K. BHATT (*Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar 388121, Gujarat, India, pri.raval@gmail.com)

      J. Liq. Chromatogr. Relat. Technol. 37, 1805-1818 (2014). HPTLC of azithromycin dehydrate (1) and cefixime trihydrate (2) on silica gel with methanol – ethyl acetate – toluene – ammonia (30 %) 45:35:20:4. Quantitative determination (A) by absorbance measurement at 366 nm or (B) after spraying with stannic chloride reagent (40 mL chloroform and 40 mL glacial acetic acid were mixed and 5 mL of stannic chloride was slowly added) or (C) ethanolic sulfuric acid (20 mL of concentrated sulfuric acid in 80 mL of ethanol) followed by absorbance measurement at 450 nm for (B) and (C). The hRF values for (1) and (2) were 80 and 27 for (A) and (B) and 67 and 30 for (C). Due to concentrated sulfuric acid, (C) showed a slight change in hRF. Linearity for (1) was in the range of 1000-5000 ng/zone (A), 1500-5000 ng/zone (B) and 1000-6000 ng/zone (C) and for (2) was 400-2000 ng/zone (A), 1600-4000 ng/zone (B) and 800-2400 ng/zone (C). The intermediate/inter-day/intra-day precision was below 2 % (n=3). The LOD and LOQ for (1) was 85 and 257 ng/zone (A), 119 and 360 ng/zone (B) and 39 and 119 ng/zone (C) and for (2) it was 36 and 110 ng/zone (A), 194 and 588 ng/zone (B) and 69 and 208 ng/zone (C), respectively. Recovery was in the range of 98.2-102.4 % for both (1) and (2).

      Classification: 28a
      117 102
      Chromatographic separation studies of carbapenem antibiotics on silica gel G layers with different solvent
      systems
      J. SINGH*, S. SHUKLA, M. SHARMA (*Amity Institute of Forensic Sciences, Amity University, Sec 125, Noida (UP), India; and M. Sharma, Forensic Science Laboratory,
      Rohini, New Delhi, India, jaskaransingh630@gmail.com)

      J. Planar Chromatogr. 29, 229-231 (2016). HPTLC of imipenem, meropenem, doripenem and eratapenem on silica gel G with 11 developing systems. Detection by spraying with iodine solution (0.2 g of potassium iodine and 0.4 g of iodine_x000D_ mixed in 20 mL of ethanol and 5 mL of hydrochloric acid), ninhydrin reagent (0.1 % ninhydrin in ethanol) or potassium permanganate solution (1 mg dissolved in 10 mL of water). The hRF values for the studied carbapenems in each developing system ranged between 13 and 58.

      Classification: 28a, 32a
      121 024
      Screening of macrocycles retention for microplanar analytical devices involving host-guest interactions and silica or octadecylsilica adsorbents
      P. ZARZYCKI (Department of Environmental Technologies and Bioanalytics, Faculty of Civil Engineering, Environmental and Geodetic Sciences, Koszalin University of Technology, ?niadeckich 2, 75-453 Koszalin, Poland, pkzarz@wp.pl)

      J. Liq. Chromatogr. Relat. Technol. 41, 315-323 (2018). HPTLC of three types of macrocyclic compounds, i.e. (1) cyclodextrins, (2) calixarenes and (3) macrocyclic antibiotics, on silica gel or RP-18 with different compositions of water – organic liquids (methanol, ethanol, acetonitrile). Detection of (1) on silica gel with a 1:1 mixture of 10 % α-naphthol in ethanol and 10 % sulfuric acid in water, followed by heating at 120 °C for 5-10 min; and on RP18 W by spraying with a 25 % methanolic solution of sulfuric acid, followed by heating at 120 °C for 5-10 min. Detection of (2) by spraying with 20 % aqueous solution of perchloric acid, followed by heating at 120 °C for 5 min. A comprehensive retention data set was obtained for fast selection of mobile phase compositions.

      Classification: 5b, 10b, 28a
      56 120
      Chinese J
      P. HONGSHENG, H. WEIYUE, G. MEIYINC

      of Medicine Industry 12, 30-31 (1983) (Chinese) (Screening of antibiotics by thin-layer chromatography and bioautography.) TLC of antibiotics on silica with chloroform - methanol - NH3 in different proportions. Detection by overlaying the plate with agarose gel containing neutral red, protein, beef extract, NaCl, glucose and test bacteria, e.g. Escherichia coli, and incubating at 37 °C for 18-24 hr: red bacteria areas and yellow inhibition zones.

      Classification: 28a