Cumulative CAMAG Bibliography Service CCBS

Our CCBS database includes more than 11,000 abstracts of publications. Perform your own detailed search of TLC/HPTLC literature and find relevant information.

The Cumulative CAMAG Bibliography Service CCBS contains all abstracts of CBS issues beginning with CBS 51. The database is updated after the publication of every other CBS edition. Currently the Cumulative CAMAG Bibliography Service includes more than 11'000 abstracts of publications between 1983 and today. With the online version you can perform your own detailed TLC/HPTLC literature search:

  • Full text search: Enter a keyword, e.g. an author's name, a substance, a technique, a reagent or a term and see all related publications
  • Browse and search by CBS classification: Select one of the 38 CBS classification categories where you want to search by a keyword
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Registered users can create a tailor made PDF of selected articles throughout CCBS search – simply use the cart icon on the right hand of each abstract to create your individual selection of abstracts. The saved items can be printed to PDF using the print function of your web browser.

      126 004
      Application of TLC to evaluate the lipophilicity of newly synthesized betulin derivatives
      Ewa BEBENEK*, K. BOBER-MAJNUSZ, S. SIUDAK, E. CHROBAK, M. KADELA-TOMANEK, J WIETRZYK, S. BORYCZKA (*Dep. of Org. Chem., Faculty of Pharm. Sci. in Sosnowiec, Med. Univ. of Silesia in Katowice, 4 Jagiellonska Str., 41-200 Sosnowiec, Poland, ebebenek@sum.edu.pl)

      J. of Chromatogr. Sci. 58 (4), 323 - 333 (2020). Application of TLC to evaluate the lipophilicity of triterpenes, newly synthesized betulin and betulone derivatives with anticancer activity, in order to find the correlation between theoretically and experimentally calculated values of lipophilicity and the structure of compounds. Investigation of the relationships between lipophilicity and pharmacokinetic parameters or anticancer activity. Similarity analysis was performed to divide the compounds into groups regarding their use as suitable medicine substances. Study of the differences in the compounds grouping in relation with the values of lipophilicity calculated by computer software or obtained by TLC through cluster analysis, clearly shows that the theoretically calculated values of lipophilicity are strongly connected to the structure of the compounds.

      Keywords:
      Classification: 3
      125 031
      Impregnated silica-based layers in thin layer chromatography
      Anna SOBANSKA (Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, Lodz 90-151, Poland, anna.sobanska@umed.lodz.pl)

      J. Liq. Chromatogr. Relat. Technol. 43, 319-327 (2020). Review of impregnated agents used in TLC and their applications in analytical and medicinal chemistry. Impregnation with inorganic ions, chelating reagents, lipophilic substances, surfactants, chiral selectors and ionic liquids were discussed.

      Classification: 1b, 3b
      125 037
      Comprehensive HPTLC fingerprinting: A novel economic approach to evaluating the quality of Ganoderma lucidum fruiting body
      Débora FROMMENWILER*, D. TREFZER, M. SCHMID, S. CAÑIGUERAL, E. REICH (*Unit of Pharmacology, Pharmacognosy and Therapeutics, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-3, ES-08028 Barcelona, Spain, debora.frommenwiler@camag.com)

      J. Liq. Chromatogr. Relat. Technol. 43, 414-423 (2020). HPTLC fingerprint of Ganoderma lucidum fruiting body on silica gel with toluene - tetrahydrofuran - acetic acid 70:30:1. Detection by dipping into a solution of 10% sulfuric acid in methanol, followed by heating at 100 ºC for 3 min. Qualitative determination under UV light at 254 and 366 nm. The hRF values for ganoderic acids D, B, A, G and C2 were in the zone between 10 and 50. This zone was used for quantification of total triterpene acids by absorbance measurement at 260 nm. Linearity of each of the main peaks between hRF 10 to 50 was determined. The linear range of ganoderic acid A was between 200 and 500 ng/zone.  The study proposes a new method for evaluation, based on “comprehensive high-performance thin layer chromatography (HPTLC) fingerprinting.” Instead of several different methods using different chromatographic techniques, a single HPTLC analysis for identification of Ganoderma lucidum fruiting body with a test for adulteration and quantitative determination of the content of total triterpene acids is proposed. As an alternative to the current tests in the  USP monograph on G. lucidum fruiting body this HPTLC method is a single, low-cost test, which eliminates the UHPLC assay of total triterpene acids.

      Classification: 3g, 14
      125 039
      Preliminary results of layer chromatography combined with bilateral band compression to search active minor components
      Agnes MORICZ*, E. MINCSOVICS, P. OTT (*Plant Protection Institute, Centre for Agricultural Research, Budapest 1022, Hungary, moricz.agnes@agrar.mta.hu)

      J. Liq. Chromatogr. Relat. Technol. 43, 300-304 (2020). HPTLC of thymol, carvacrol and linalool in Solidago canadensis on silica gel with n-hexane - acetone 4:1. The method was compared with bilateral band compression (BBC) of the 10 mm wide lanes of HPTLC separation, resulting in more than 6 times increase in peak height and peak area. In BBC a solvent flow perpendicular to the direction of chromatogram development squeezes the chromatographic bands into a smaller area The method improved detection sensitivity of sample components with low abundance.

      Classification: 3d
      124 053
      Highly-porous diatom biosilica stationary phase for thin-layer chromatography
      J.A. KRAAI, G.L. RORRER*, A.X. WANG (*School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA, gregory.rorrer@oregonstate.edu)

      J. of Chromatogr. A 1591, 162-170 (2019). TLC of malachite green (1) and fast green (2) on diatom biosilica (a nanostructured, porous stationary phase composed of randomly-deposited biosilica frustules isolated from living cells of diatom Pinnularia sp.) instead of conventional silica gel with 1-butanol - ethanol - water 9:1:1 and 1-butanol - acetic acid - water 5:1:2. Diatom biosilica reduced the flow velocity and permeability constant by a factor two compared to silica gel and thus improved the resolution of (1) and (2). The theoretical plate height for both analytes was reduced ten-fold with 1-butanol - acetic acid - water 5:1:2, and the difference in retention time between malachite green and fast green was increased (ΔhRF 26) with 1-butanol - ethanol - water 9:1:1.

      Keywords:
      Classification: 3b
      123 036
      Optimized determination of caffeine, equol, and artemisinin by High-Performance Thin-Layer Chromatography–direct analysis in real time–time of flight–mass spectrometry
      F. EICHNER, B. SPANGENBERG* (*University of Applied Sciences Offenburg, Department of Process Engineering, Badstrasse 24, 77652 Offenburg, Germany, Spangenberg@HS-Offenburg.de)

      J. Planar Chromatogr. 32, 197-203 (2019). HPTLC of equol (1), artemisinin (2) and caffeine (3) on silica gel with methyl t-butyl ether - cyclohexane 1:1 for (1), cyclohexane - ethyl acetate 7:3 for (2) and ethyl acetate - acetone 7:3 for (3). The plate was scanned with a DART–TOF MS system to optimize the measurement conditions. The hRF values for (1) to (3) were 71, 63 and 53, respectively. LOD and LOQ were 1.2 and 1.8 µg/zone for (1), 225 and 315 ng/zone for (2) and 270 and 490 ng/zone for (3), respectivley.

      Classification: 3f
      123 052
      Visualization reagent for the identification of phthalates
      A. BAJAJ*, C. JOHN, A. CHAUHAN, R. TRIPATHI (*Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Chandigarh 160036, India, atulbajaj37@gmail.com)

      J. Planar Chromatogr. 32, 55-57 (2019). TLC of dimethyl phthalate, diethyl phthalate, di-n-butyl phthalate, diisobutyl phthalate, diallyl phthalate, and bis(2-ethylhexyl) phthalate on silica gel with petroleum ether - ethyl acetate - phosphoric acid 9:1:1. Detection by spraying with 0.1 % 2,6-dichlorophenolindophenol with the instantaneous appearance of pink-colored zones.

      Classification: 3e, 9
      100 014
      Phosphopeptide analysis by directly coupling two-dimensional planar electrochromatography/thin-layer chromatography with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
      V. PANCHAGNULA, A. MIKULSKIS, L. SONG, Y. WANG, M. WANG, Tanya KNUBOVETS, Elaine SCRIVENER, Eva GOLENKO, Ira KRULL, M. SCHULZ, H.E. HAUCK, W.F. PATTON* (*Biochemistry Department, PerkinElmer Life and Analytical Sciences, Waltham, MA 02451, USA; wayne.patton@perkinelmer.com)

      J. Chromatogr. A 1155 (1), 112-123 (2007). Presentation of a novel strategy for the fractionation of complex peptide mixtures using two-dimensional planar electrochromatography/thin-layer chromatography (2D PEC/TLC). It was found that phosphopeptides migrate more slowly in the first dimension, based upon their anionic phosphate residues, and certain predominantly acidic phosphopeptides even migrate in the opposite direction, relative to the bulk of the peptides. Further distinguishing phosphopeptides based upon hydrophilicity in the second dimension, which permits a restricted region of the plate to be directly interrogated for the presence of phosphopeptides by MS. Discussion of peptide sequencing and identification of phosphopeptide from the plates by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF)-MS and tandem MS.

      Classification: 3