J. Chromatogr. A 822, 263-269 (1998). Determination of the relative lipophilicity of ten non-steroidal anti-inflammatory agents by reversed-phase TLC using different plates and water - methanol mixtures as eluents. Investigation of the retention behavior of the compounds, their Rm values decrease linearly with increasing concentration of methanol in the eluents. Estimation and comparison of lipophilicity of the "congeneric lipophilicity chart".

Chinese Anal. Chem. (Fenxi Huaxue) 30 (1), 38-41 (2002). TLC on polyamide with cyclodextrins (0-8 x 10-3 mol/L) as mobile phase and NH3(H2O-NH4Cl, pH 9.7 as buffer. Detection under UV. Investigation of the interaction between emodin, aloe-emodin and six cyclodextrins. Comparison of the inclusion capacity of different cyclodextrins. Calculation of the thermodynamic parameters of the interaction. Discussion of use of this interaction to modify the biological properties of emodin and aloe-emodin.

J. Chromatogr. Sci. 43 (10), 542-548 (2005). The usefulness of TLC as an efficient measuring technique in the studies of oscillatory trans-enantiomerization of profens from the S to the R configuration (and vice versa) during their storage as 70 % ethanol solutions is demonstrated in the literature. S-(+)-ibuprofen, S-(+)-naproxen, and S,R-(±)-2-phenylpropionic acid are utilized as the test profens. It is proven possible to show oscillatory instability with the racemic S,R-(±)-2-phenylpropionic acid also. Correctness of the TLC assessment is successfully confirmed by means of polarimetry. Upon these preliminary results, it is concluded that the most probable mechanism might embrace the keto-enol tautomerism because of a convenient migration of the proton from one moiety of the profen molecule to another in an aqueous medium. To indirectly verify this hypothesis, profens are stored in dichloromethane, deliberately hampering their ability to dissociate and to re-structure. It is shown that the non-aqueous solvent considerably suppresses, although they do not completely eradicate, the oscillatory trans-enantiomerization of profens. In view of these findings, the reports which claim a predominant therapeutic potential of the respective S-profens become less convincing and certainly need reconsideration.

J. Chromatogr. Sci. 53 (2), 312-319 (2015). Investigation of lipophilicity for newly synthesized N-substituted-2-phenylacetamide derivatives by TLC on RP-18 in the presence of one protic (methanol) and one aprotic solvent (acetonitrile) followed by mathematical evaluation using different software packages. Establishment of the dependences between the partition coefficient, log P as the standard measure of lipophilicity and the alternative lipophilic parameters using the retention chromatographic constant RM0 and m values (the intercept and the slope of the linear dependence between volume fractions of the organic solvent and the retention parameters obtained experimentally by TLC), employing linear regression analysis and multivariate methods, cluster analysis (CA) and principal component analysis (PCA). All applied methods gave approximately similar results. Although there is a linear dependence between the two chromatographic parameters RM0 and m, only RM0 shows suitable similarity with the standard measure of lipophilicity of the investigated N-substituted-2-phenylacetamide derivatives at the given conditions. This proves that the chromatographic retention constant, RM0, obtained by reversed phase TLC could be successfully used for the description of lipophilicity of the compounds. The results confirmed that the applied linear regression analysis and the multivariate analysis (CA and PCA) have the ability to compare lipophilic parameters of the investigated phenylacetamide derivatives obtained in different ways.

Anal. Letters 21, 1075-1084 (1988). TLC on silica impregnated with metal salts with a) chloroform - butyl acetate 10:5 and b) chloroform - ethyl acetate 25:2. Detection by exposing to iodine vapor. Determination of the partition coefficients and the correlation with Rf values.

J. Planar Chromatogr. 3, 144-148 (1990). Study of RM versus solvent composition relationships with 16 binary eluents composed of four diluents (heptane, chloroform, dichloromethane, trichloroethylene) and four modifiers (ethyl acetate, MEK, ether, diisopropyl ether) for 57 aromatic solutes (azaarenes, anilines, phenols, phenolic acids and their derivatives). Linear RM versus logCmod plots were obtained in almost all of the above cases, permitting storage of the data in computer memory.

J. Planar Chromatogr. 6, 438-445 (1993). Multiple development in TLC provides a straightforward means of improving the separation capacity obtained by normal development. Maximum separation power in isocratic multiple development is obtained when the distance between the solvent entry position and the sample application position is minimized and when the solvent entry position and the solvent front are incremented at each development step. Concerning the resolution the solvent selectivity is the most important parameter. A further advantage of multiple development methods is the ease of automation and the possibility of incorporating solvent gradients into the separation strategy.

J. Planar Chromatogr. 9, 92-97 (1996). Investigation of mixed (adsorption - partition) retention mechanisms on normal phase cyano, amino, and diol stationary phases with binary alcohol - n-aliphatic hydrocarbon eluents. The impact of the nature of the chemically bonded ligand and of the qualitative composition of the mixed mobile phase on the relative amounts of adsorption and partition has been clearly demonstrated for a selection of test solutes.