CBS 81, 10-12 (1998). A number of applications of HPTLC in the bulk drug industry are presented: process optimization, fermentation process monitoring, impurity profile, vessel residue certification and bulk drug analysis. The technique is advantageous when a large number of similar samples is to be analyzed and time and cost considerations are of importance.

Acta Chrom. 6, 21-38 (1996). The possibility of using a thermodynamic approach for optimization of mixed mobile phases for systems with binary and ternary solvents is discussed, as well as the method for predicting separation results in column liquid chromatography on the basis of experimental thin-layer chromatographic data. The effect of mobile phase composition on solute retention is described by solute capacity factors (characteristic of the pure solvents), molecular interactions occurring in the bulk phase and adsorption equilibrium in a given adsorbent – binary solution system. Two kinds of chambers were used in the investigation: a saturated Stahl chamber and a sandwich chamber. The study described the use of different TLC techniques as pilot methods for HPLC.

Chromatography the State of Art, Vol. II, Akademiai Kiado, Budapest 1985, 751-757 RM values of 36 quaternary ammonium steroids were determined by reversed-phase thin-layer chromatography. The RM values of these compounds, deviating from the general role, do not change linearly with the organic solvent ratio of the eluent. TLC on silica impregnated with 5 % paraffin oil in hexane with dioxane - water 7:3, 8:2, 9:1. Detection with iodine vapor.

1. Solvent strength of mixtures for polymeric samples. Bull. Inst. Chem. Res., Kyoto Univ. 63, 313-319 (1985) (publ. 1986). Discussion on the validity of Snyder's solvent strength theory. Investigation of mixed solvents for an adsorption case where a sample molecule displaces some solvent molecules while the 1:1 molecule displacement reaction takes place among component solvents.

(Chinese). Chinese Anal. Chem. 15, 151-152 (1987) (Fenxi Huaxue). Presentation of a method for numerical taxonomy and information content calculation of Rf values by a computer. Comparison of the calculated results with those of TLC experiments of 24 cations on silica.

J. Chromatogr. 434, 455-463 (1988). Study of the interaction between amino acids by charge-transfer reversed-phase TLC. Elucidation of the role of various physicochemical parameters of amino acids in the interaction. Discussion of the effect of pH and salt concentration on the strength of interaction.

Chromatogr. Sci. 52, 453- 463 (1990). Discussion of TLC as a pilot method for HPLC, due to the good correlation obtained between log k in HPLC and Rf values in TLC, as well as having fewer requirements for reagents and instrumentation in TLC.

J. Chem. Zduc. 71, 1075-1077 (1994). Presentation of a colorful demonstration of TLC by the separation of combinations of seven highly colored dyes.