J. Planar Chromatogr. 10, 434-440 (1997). Investigation of the retardation behavior of ten closely related cyanobacterial hepatotoxins by parts I and II of the PRISMA system, operating in the irregular part of the PRISMA model. The mobile phase combination and the area of the triangular plane to be studied were selected in preassays and the retardation behavior was studied at sixteen selectivity points. The retardation of all the toxins followed a second-order function with high correlation. The three-dimensional retention surfaces described the mobility and the structural variances of the toxins. Cyanobacterial hepatotoxins behaved predictably in the selected system in the irregular part of the PRISMA model. HPTLC of 10 microcystins on silica with varying ratios of solvents. Densitometry at 240 nm.

Chinese J. Chromatogr. (Sepu) 17, 18-20 (1999). Determination of the Rf values of 24 phenol and aniline derivatives on silica with mixtures of hexane - ethyl acetate in various proportions. Classification of the compounds into two species with different features by oblique factor analysis. Discussion of the effects of the molecular structure on the retention value for the two species. Multi-parameter regression analysis of Rf values with the topological indexes, showing good correlation for both groups.

J. Planar Chromatogr. 12, 461-465 (1999). Investigation of the effect of enlargement of the chelate ring size in Co(III) complexes containing bidentate aminocarboxylato and/or diamine ligands on their Rf values in salting-out chromatography on thin layers of silica gel, cellulose, polyacrylonitrile, and CN-modified silica gel. Development with aqueous solutions of ammonium sulfate. Detection by spraying with freshly prepared saturated aqueous solutions of sodium sulfide.

J. Liqu. Chromatogr. 25, 1301-1315 (2002). Formulation of qualitative relationships between physical and chromatographic parameters and topological indices, based on adjacency matrix and distance matrix. TLC of g- and a-terpinene and on silica gel, impregnated with an aqueous solution of silver nitrate (0%, 5%, 10%, 15%, 20% or 25%) with benzene. Detection under UV 254 nm. Determination of the optimal conditions.

Part I. J. Chromatogr. A 1007 (1-2), 145-155 (2003). A quantitative structure-activity relationship analysis of H1-antihistamine activity and chromatographic data of 2-[2-(phenylamino)thiazol-4-yl]ethanamine; 2-(2-benzyl-4-thiazolyl)ethanamine; 2-(2-benzhydrylthiazol-4-yl)ethylamine derivative; 2-(1-piperazinyl- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives were collected. Silica gel RP2, impregnated with solutions of selected amino acid mixtures (-Asp, -Asn, -Thr and -Lys), were used in two developing solvents as hH1R antagonistic interaction models. Using regression analysis, the relationships between chromatographic and biological activity data were found. The correlations obtained in regression analysis for the examined thiazole and benzothiazole derivatives with H1-antihistamine activity [pA2(H1)] represent their interaction with all the proposed biochromatographic models (S1–S7). Some of the calculated equations can be applied to predict the pharmacological activity of new drug candidates. The best multivariate relationships useful in predicting the pharmacological activity of thiazole and benzothiazole derivatives were obtained on RP2 phase with acetonitrile - methanol - buffer 2:2:1. The log P values of particular compounds are extremely important for this kind of activity.

J. Chromatogr. A 1211 (1-2), 49-54 (2008). Presentation of a spreadsheet that provides information on the amount of silica gel needed, the optimal fraction size, and the degree of separation to be expected before flash chromatography is attempted. Information is based on sample mass and TLC data given. This is the first utility of its kind to accurately estimate the retention volume and band volume of analytes, as well as the fraction numbers expected to contain each analyte, and the resolution between adjacent peaks. The information allows users to select optimal parameters for preparative-scale separations before the flash column itself is attempted; ensuring a successful first separation.

J. Chromatogr. Sci. 56 (4), 376-381 (2018). Investigation of the lipophilicity of new anticancer active 10-substituted 1,6- and 3,6-diazaphenothiazines using RP TLC. Determination of their lipophilicity (RM0 and log PTLC) with mixtures of acetone and Tris buffer as mobile phases. The obtained results showed significant intercorrelation between RM0 and the specific hydrophobic surface area b, revealing congeneric classes of diazaphenothiazines. Transformation of the parameter RM0 into parameter log PTLC by use of the calibration curve. Comparison of the parameter log PTLC with computationally calculated lipophilic parameters log Pcalcd. Discussion of the lipophilicity with the structure elements and correlation with molecular descriptors, ADME properties and in vitro anticancer activities.

RM values as lipophilicity parameters. J. Chromatogr. 504, 163-178 (1990). Measurement of RM values for a series of 41 cardiac glycosides and aglycones. Calculation of the RM values for 19 compounds by means of the D RM values. Discussion of the correlation of the measured RM values with literature-reported values, HPLC data and octanol- water partition coefficients (log p).