CAMAG Seminar  "Online Coupling HPTLC-MS"

Locations	June 3, 2010, University of Leiden (NL) June 4, 2010, University of Gent (B)
Moderators	Dr. Konstantinos Natsias, CAMAG, Berlin/GER Dick Bruynzeel, BCON Instruments, Sint-Annaland/NL
Registration	link to registration
Costs	Free
Download program	«Online Coupling HPTLC-MS»

Seminar content:

The identification by mass spectrometry of substances that have been separated by thin layer chromatography is in principle nothing new. What is new are the recent developments and advancements connecting TLC/HPTLC with MS.

The research of Dr. Luftmann, Head of Mass Spectrometry, WestfŠlische Wilhelms University in MŸnster, and Dr. Morlock, associate professor at the University of Hohenheim in Stuttgart, has lead to the availability of a powerful semi-automated solution to the hyphenation of thin layer chromatography and mass spec, thereby opening up new possibilities for both techniques.

The CAMAG TLC-MS interface provides fast, contamination-free extraction of TLC/HPTLC zones directly from the plate surface, followed by online transfer to a mass spectrometer. One of the big advantages of this universal interface is the simplicity of the modification free integration with the system, making it truly plug and play.

Depending on your mass spectrometer, it is possible to identify in one minute the mass of the unknown substance and the related sum formula. The detectability is comparable to HPLC-MS, since the entire, three dimensional zone of the compound is extracted.

Also you can extract zones of interest into a vial for further investigations, for example using NMR, (ATR) FTIR, static nanospray, direct EI-MS and MALDI. Interested?

At this workshop experts will report in four lectures on their recent results with the TLC-MS interface. Please feel free to bring your own TLC chromatogram along for investigation but let us know in advance what you plan to bring.